Gene Symbol: TEX1
Species: Saccharomyces cerevisiae S288c
Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez Navarro S, et al
. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002;417:304-8 pubmed
..Our data indicate that the TREX complex has a conserved role in coupling transcription to mRNA export. ..
Peña A, Gewartowski K, Mroczek S, Cuellar J, Szykowska A, Prokop A, et al
. Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. EMBO J. 2012;31:1605-16 pubmed publisher
..In yeast, this complex has been described as a heterotetramer (Tho2, Hpr1, Mft1, and Thp2) that interacts with Tex1 and mRNA export factors Sub2 and Yra1 to form the TRanscription EXport (TREX) complex...
Konopka C, Locke M, Gallagher P, Pham N, Hart M, Walker C, et al
. A yeast model for polyalanine-expansion aggregation and toxicity. Mol Biol Cell. 2011;22:1971-84 pubmed publisher
..Thus longer expansions may have a different mechanism for toxicity. We think that this difference underscores the potential need to examine the cytotoxic mechanisms of both long and short expansions in models of expansion disorders. ..
Meinel D, Burkert Kautzsch C, Kieser A, O Duibhir E, Siebert M, Mayer A, et al
. Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. PLoS Genet. 2013;9:e1003914 pubmed publisher
..In summary, we provide insight into how the phospho-code of the CTD directs mRNP formation and export through TREX recruitment...