Gene Symbol: TEL1
Description: DNA-binding protein kinase TEL1
Alias: DNA-binding protein kinase TEL1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ritchie K, Mallory J, Petes T. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:6065-75 pubmed
    ..Strains with a mutation of TEL1, a homolog of the human gene (ATM) mutated in patients with ataxia telangiectasia, have short but stable telomeric ..
  2. Hirano Y, Sugimoto K. Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends. Mol Biol Cell. 2007;18:2026-36 pubmed
    ..In budding yeast, Mec1 and Tel1 correspond to ATR and ATM, respectively...
  3. D Amours D, Jackson S. The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev. 2001;15:2238-49 pubmed
    ..These results indicate that the Tel1p/ATM signaling pathway is conserved from yeast to humans and suggest that the Xrs2p/Nbs1 complexes act as signal modifiers. ..
  4. Puglisi A, Bianchi A, Lemmens L, Damay P, Shore D. Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition. EMBO J. 2008;27:2328-39 pubmed publisher
    ..These data provide new insights into the coordination of telomere capping and telomerase regulation. ..
  5. Nakada D, Matsumoto K, Sugimoto K. ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev. 2003;17:1957-62 pubmed
    In budding yeast, TEL1 encodes a protein closely related to ATM. Xrs2 is an Nbs1 homolog and forms a complex with Mre11 and Rad50...
  6. Carballo J, Johnson A, Sedgwick S, Cha R. Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination. Cell. 2008;132:758-70 pubmed publisher
    ..Involvement of Mec1 and Tel1, the budding yeast homologs of the mammalian ATR and ATM kinases, in meiotic interhomlog bias has been implicated, ..
  7. Toh G, Sugawara N, Dong J, Toth R, Lee S, Haber J, et al. Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails. DNA Repair (Amst). 2010;9:718-26 pubmed publisher
    ..Slx4 is phosphorylated by the Mec1 and Tel1 kinases after DNA damage on at least six Ser/Thr residues, and mutation of all six residues to Ala reduces the ..
  8. Anderson C, Blackburn E. Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle. 2008;7:3695-8 pubmed
    ..Our previous work in the yeast Saccharomyces cerevisiae showed that Tel2 interacts with the PIKK Tel1 (yeast ATM kinase), and that this interaction is abrogated by the only known non-lethal TEL2 mutation in S...
  9. Schmidt K, Wu J, Kolodner R. Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein. Mol Cell Biol. 2006;26:5406-20 pubmed
    ..The S-phase checkpoint kinase and telomere maintenance factor Tel1, a homolog of the human ataxia telangiectasia (ATM) protein, prevents these translocations, whereas the checkpoint ..

More Information


  1. Carballo J, Panizza S, Serrentino M, Johnson A, Geymonat M, Borde V, et al. Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genet. 2013;9:e1003545 pubmed publisher
    ..evolutionarily conserved essential component of the meiotic DSB-machinery, interacts with DSB hotspot DNA, and that Tel1 and Mec1, the budding yeast ATM and ATR, respectively, down-regulate Rec114 upon meiotic DSB formation through ..
  2. Downs J, Lowndes N, Jackson S. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature. 2000;408:1001-4 pubmed
    ..In addition, the motif has a role in determining higher order chromatin structure. Thus, phosphorylation of a core histone in response to DNA damage may cause an alteration of chromatin structure that facilitates DNA repair. ..
  3. Cheng Y, Chuang C, Shen H, Lin F, Wang T. Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis. Mol Cell Biol. 2013;33:3365-76 pubmed publisher
    ..Incomplete synapsis and unrepaired DNA are monitored by Mec1/Tel1-dependent checkpoint responses that prevent exit from the pachytene stage...
  4. Lee K, Zhang Y, Lee S. Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations. Nature. 2008;454:543-6 pubmed publisher
    ..We show that interchromosomal end joining is efficiently suppressed by the Tel1- and Mre11-Rad50-Xrs2-dependent pathway; this is distinct from the role of Tel1 in telomeric integrity and from ..
  5. Liang B, Qiu J, Ratnakumar K, Laurent B. RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Curr Biol. 2007;17:1432-7 pubmed
    ..Several proteins, including the MRX/N complex, Tel1/ATM (ataxia telangiectasia mutated), and Mec1/ATR (ATM and Rad3 related), have been proposed as sensors of DNA ..
  6. Kitada T, Schleker T, Sperling A, Xie W, Gasser S, Grunstein M. ?H2A is a component of yeast heterochromatin required for telomere elongation. Cell Cycle. 2011;10:293-300 pubmed
    ..yeast telomeric and silent mating locus (HM) heterochromatin where ?H2A results from the action of kinases Tel1 and Mec1...
  7. Morrow D, Tagle D, Shiloh Y, Collins F, Hieter P. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell. 1995;82:831-40 pubmed
    ..the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1...
  8. Smith S, Gupta A, Kolodner R, Myung K. Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae. DNA Repair (Amst). 2005;4:606-17 pubmed
    ..However, the non-homologous end joining function of MRX complex does not appear to participate in the suppression of GCRs. ..
  9. Martina M, Clerici M, Baldo V, Bonetti D, Lucchini G, Longhese M. A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres. Mol Cell Biol. 2012;32:1604-17 pubmed publisher
    ..on the MRX (Mre11-Rad50-Xrs2) complex, which is also necessary to maintain telomere length by recruiting the Tel1 kinase. MRX physically interacts with Rif2, which inhibits both resection and elongation of telomeres...
  10. Chan S, Chang J, Prescott J, Blackburn E. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol. 2001;11:1240-50 pubmed
    ..telomere structure in three different ways showed that telomerase can function in ATM kinase-deleted cells: tel1 mec1 cells senesced more slowly than tel1 mec1 cells that also lacked TLC1, which encodes telomerase RNA, ..
  11. Lustig A, Petes T. Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A. 1986;83:1398-402 pubmed
    ..From our analysis of these mutants as well as other data, we suggest that the duplication of the telomeric poly(C1-3A) tract involves two processes, semiconservative replication and untemplated terminal addition of nucleotides. ..
  12. Li J, Coïc E, Lee K, Lee C, Kim J, Wu Q, et al. Regulation of budding yeast mating-type switching donor preference by the FHA domain of Fkh1. PLoS Genet. 2012;8:e1002630 pubmed publisher
    ..Donor preference is independent of Mec1/ATR and Tel1/ATM checkpoint protein kinases but partially depends on casein kinase II...
  13. Grandin N, Damon C, Charbonneau M. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment. Mol Cell Biol. 2000;20:8397-408 pubmed
    ..Our results represent the first evidence of a direct control of the telomerase-loading function of Cdc13 by a double-strand telomeric DNA-binding complex. ..
  14. Cartagena Lirola H, Guerini I, Viscardi V, Lucchini G, Longhese M. Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis. Cell Cycle. 2006;5:1549-59 pubmed
    ..Accordingly, Sae2 phosphorylation depends on the checkpoint kinases Mec1 and Tel1, whose simultaneous deletion also impairs meiotic DSB repair...
  15. Hirano Y, Fukunaga K, Sugimoto K. Rif1 and rif2 inhibit localization of tel1 to DNA ends. Mol Cell. 2009;33:312-22 pubmed publisher
    ..In budding yeast, the ATM homolog Tel1 associates preferentially with short telomeres and promotes telomere addition...
  16. Mallory J, Bashkirov V, Trujillo K, Solinger J, Dominska M, Sung P, et al. Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair (Amst). 2003;2:1041-64 pubmed
    ..Opin. Cell Biol. 13 (2001) 281]. Saccharomyces cerevisae strains with mutations in the TEL1 gene (encoding an ATM-like protein kinase) have very short telomeres, as do strains with mutations in XRS2, RAD50, ..
  17. Baldo V, Testoni V, Lucchini G, Longhese M. Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response. Mol Cell Biol. 2008;28:358-75 pubmed safeguarded by two highly conserved protein kinases that are called ATR and ATM for humans and Mec1 and Tel1 for Saccharomyces cerevisiae...
  18. Pennaneach V, Kolodner R. Recombination and the Tel1 and Mec1 checkpoints differentially effect genome rearrangements driven by telomere dysfunction in yeast. Nat Genet. 2004;36:612-7 pubmed
    ..Inactivation of Tel1 or either the Rad51 or Rad59 recombination pathways in telomerase-deficient cells increased the GCR rate, even ..
  19. Lee K, Lee S. Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics. 2007;176:2003-14 pubmed
    ..The mismatch repair proteins, Rad52 group genes, and Rad27 are dispensable for MMEJ. Sae2 and Tel1 promote MMEJ but inhibit NHEJ, likely by regulating Mre11-dependent ssDNA accumulation at DNA break...
  20. Di Domenico E, Auriche C, Viscardi V, Longhese M, Gilson E, Ascenzioni F. The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions. DNA Repair (Amst). 2009;8:209-18 pubmed publisher
    ..Furthermore, in the absence of either TEL1/ATM or MEC1/ATR genes, which encodes phosphatidylinositol 3-kinase-related kinases (PIKKs), we detected telomere ..
  21. Mallory J, Petes T. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A. 2000;97:13749-54 pubmed
    ..Tel1p phosphorylates serine in an SQ motif in PHAS-I. Mutations in the kinase domains of Tel1p and Mec1p result in loss of in vitro kinase activity and the in vivo phenotypes associated with the null tel1 and mec1 mutations.
  22. Takata H, Kanoh Y, Gunge N, Shirahige K, Matsuura A. Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell. 2004;14:515-22 pubmed
    ..Our study suggests a mechanistic similarity between telomere length regulation and DNA double-strand break repair, both of which are achieved by the direct association of PIKKs...
  23. Hang L, Liu X, Cheung I, Yang Y, Zhao X. SUMOylation regulates telomere length homeostasis by targeting Cdc13. Nat Struct Mol Biol. 2011;18:920-6 pubmed publisher
    ..cdc13-snm's effect on telomere length is epistatic with stn1, but not with yku70, tel1 or est1 alleles, and is suppressed by Stn1 overexpression...
  24. Zhang W, Durocher D. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev. 2010;24:502-15 pubmed publisher
    ..These studies therefore identify a mechanism by which the ATR family of kinases enforces genome integrity, and a process that underscores the contribution of Cdc13 to the fate of DNA ends. ..
  25. Gao H, Toro T, Paschini M, Braunstein Ballew B, Cervantes R, Lundblad V. Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13. Genetics. 2010;186:1147-59 pubmed publisher
    ..A current model proposes that Tel1 binding to telomeres marks them for elongation, as the result of phosphorylation of a proposed S/TQ cluster in the ..
  26. Goudsouzian L, Tuzon C, Zakian V. S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell. 2006;24:603-10 pubmed
    ..These data argue that Mre11p and Tel1p affect telomere length by promoting telomerase recruitment to telomeres, whereas Mec1p has only a minor role in telomerase recruitment in a TEL1 cell.
  27. McCulley J, Petes T. Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. Proc Natl Acad Sci U S A. 2010;107:11465-70 pubmed publisher
    ..The Saccharomyces cerevisiae homologs of ATM and ATR are Tel1p and Mec1p, respectively. Haploid tel1 mec1 strains have very short telomeres and very high rates of chromosomal aberrations...
  28. Puddu F, Piergiovanni G, Plevani P, Muzi Falconi M. Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ?. PLoS Genet. 2011;7:e1002022 pubmed publisher
  29. Rog O, Smolikov S, Krauskopf A, Kupiec M. The yeast VPS genes affect telomere length regulation. Curr Genet. 2005;47:18-28 pubmed
    ..We present models to explain the link between vacuolar traffic and telomere length homeostasis. ..
  30. Sabourin M, Tuzon C, Zakian V. Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell. 2007;27:550-61 pubmed
    ..Tel1p binding was dependent on Xrs2p and required for preferential binding of telomerase to short telomeres. These data suggest that Tel1p targets telomerase to the DNA ends most in need of extension...
  31. Ho H, Burgess S. Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis. PLoS Genet. 2011;7:e1002351 pubmed publisher
    ..Pch2, Xrs2, and the ATM ortholog Tel1 function in the same pathway leading to the phosphorylation of Hop1, independent of Rad17 and the ATR ortholog Mec1,..
  32. Anbalagan S, Bonetti D, Lucchini G, Longhese M. Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet. 2011;7:e1002024 pubmed publisher
    ..Thus, these data highlight a novel role for Rif1 in assisting the essential telomere protection function of the CST complex. ..
  33. Craven R, Greenwell P, Dominska M, Petes T. Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics. 2002;161:493-507 pubmed
    ..In the yeast Saccharomyces cerevisiae, two members of this family, TEL1 and MEC1, have functionally redundant roles in both DNA damage repair and telomere length regulation...
  34. Arneric M, Lingner J. Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. EMBO Rep. 2007;8:1080-5 pubmed
    ..involves telomere repeat-bound Rap1, which provides a length-dependent negative feedback mechanism, and the Tel1 and Mec1 kinases, which are positive regulators of telomere length...
  35. Anderson C, Korkin D, Smith D, Makovets S, Seidel J, Sali A, et al. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev. 2008;22:854-9 pubmed publisher
    The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling...
  36. Clerici M, Baldo V, Mantiero D, Lottersberger F, Lucchini G, Longhese M. A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol. 2004;24:10126-44 pubmed sensing and transducing checkpoint signals in response to different types of DNA lesions, while the role of the Tel1/ATM kinase in DNA damage checkpoints is not as well defined...
  37. Hector R, Shtofman R, Ray A, Chen B, Nyun T, Berkner K, et al. Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell. 2007;27:851-8 pubmed
    ..Tel1p overexpression simultaneously stimulated telomerase-mediated elongation and Tel1p association with all telomeres. Thus, Tel1p preferentially associates with the shortest telomeres and stimulates their elongation by telomerase. ..
  38. Myung K, Chen C, Kolodner R. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature. 2001;411:1073-6 pubmed
    ..Mutations that inactivate these pathways cause high rates of GCRs and show synergistic interactions, indicating that the pathways that suppress GCRs all compete for the same DNA substrates. ..
  39. Kaochar S, Shanks L, Weinert T. Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2010;107:21605-10 pubmed publisher
    ..protein complex MRX(MRN) inhibit Exo1 in one pathway, whereas in a second pathway the ATR-like kinases Mec1 and Tel1, adaptor protein Rad9, and effector kinases Chk1 and Dun1 act independently of Exo1 to prevent inverted repeat ..
  40. Chang M, Arneric M, Lingner J. Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev. 2007;21:2485-94 pubmed significantly increased at extremely short telomeres, a process that is dependent on the ATM-ortholog Tel1. We propose that this enhancement of telomerase processivity at short telomeres serves to rapidly elongate ..
  41. Tseng S, Lin J, Teng S. The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res. 2006;34:6327-36 pubmed
    ..Gel analysis showed that Cdc13p contains a Mec1/Tel1-dependent post-translational modification...
  42. Nakada D, Shimomura T, Matsumoto K, Sugimoto K. The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res. 2003;31:1715-24 pubmed
    MEC1 and TEL1 encode ATR- and ATM-related proteins in the budding yeast Saccharomyces cerevisiae, respectively. Phleomycin is an agent that catalyzes double-strand breaks in DNA...
  43. Ponnusamy S, Alderson N, Hama H, Bielawski J, Jiang J, Bhandari R, et al. Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. J Biol Chem. 2008;283:27514-24 pubmed publisher
  44. Simpson Lavy K, Bronstein A, Kupiec M, Johnston M. Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae. Cell Rep. 2015;12:1865-75 pubmed publisher
    ..The DNA damage checkpoint kinases Mec1/ATR and Tel1/ATM, as well as the nutrient-sensing protein kinase A (PKA), regulate Mms21 activity toward Snf1...
  45. Karumbati A, Wilson T. Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae. Genetics. 2005;169:1833-44 pubmed
    ..We propose a model in which recombinational repair during S phase coupled with failure of the metaphase-anaphase checkpoint allows for tolerance of persistent single-strand breaks at the expense of genome stability. ..
  46. Lee C, Lee K, Legube G, Haber J. Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break. Nat Struct Mol Biol. 2014;21:103-9 pubmed publisher
    In budding yeast, a single double-strand break (DSB) triggers extensive Tel1 (ATM)- and Mec1 (ATR)-dependent phosphorylation of histone H2A around the DSB, to form ?-H2AX...
  47. Gunjan A, Verreault A. A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae. Cell. 2003;115:537-49 pubmed
    ..Our results argue that Rad53 contributes to genome stability independently of Mec1 by preventing the damaging effects of excess histones both during normal cell cycle progression and in response to DNA damage. ..
  48. Mieczkowski P, Mieczkowska J, Dominska M, Petes T. Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc Natl Acad Sci U S A. 2003;100:10854-9 pubmed
    Yeast strains with mutations in both TEL1 and MEC1 have short telomeres and elevated rates of chromosome deletions. By using a PCR assay, we demonstrate that mec1 tel1 strains also have telomere-telomere fusions (T-TFs)...
  49. Psakhye I, Jentsch S. Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell. 2012;151:807-820 pubmed publisher
    ..We propose that SUMOylation may thus often target a protein group rather than individual proteins, whereas localized modification enzymes and highly specific triggers ensure specificity. ..
  50. Di Domenico E, Mattarocci S, Cimino Reale G, Parisi P, Cifani N, D Ambrosio E, et al. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Res. 2013;41:6490-500 pubmed publisher
    ..In these cells, Y' amplification occurs by different pathways: in Tel1(+) tlc1h cells, it is Rad51-dependent, whereas in the absence of Tel1, it depends on Rad50...
  51. Clerici M, Paciotti V, Baldo V, Romano M, Lucchini G, Longhese M. Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J. 2001;20:6485-98 pubmed
    The evolutionarily conserved yeast Mec1 and Tel1 protein kinases, as well as the Mec1-interacting protein Ddc2, are involved in the DNA damage checkpoint response...
  52. Izbicka E, Barnes L, Robinson A, Davidson K, Lawrence R, Hannibal G. Alterations in DNA repair and telomere maintenance mechanism affect response to porphyrins in yeast. Anticancer Res. 2001;21:1899-903 pubmed
    ..cerevisiae wild type and strains with defects in telomere maintenance and/or DNA repair pathways (mec1, tel1, rad9), telomere binding protein (cdc13), and anaphase control (pds1)...
  53. Bergkessel M, Reese J. An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery. Genetics. 2004;167:21-33 pubmed
    ..Furthermore, the high degree of conservation between DHH1 and its human ortholog suggests that this mechanism is conserved among all eukaryotes and potentially important in human disease. ..
  54. Fu Q, Chow J, Bernstein K, Makharashvili N, Arora S, Lee C, et al. Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme. Mol Cell Biol. 2014;34:778-93 pubmed publisher
    ..Overall, this analysis provides evidence for a novel type of protein regulation where the activity of an enzyme is controlled dynamically by posttranslational modifications that regulate its solubility and oligomeric state. ..
  55. Ruiz J, Pardo B, Sastre Moreno G, Aguilera A, Blanco L. Yeast pol4 promotes tel1-regulated chromosomal translocations. PLoS Genet. 2013;9:e1003656 pubmed publisher
    ..In addition, we have discovered that Pol4-Thr(540) amino acid residue can be phosphorylated by Tel1/ATM kinase, which could modulate Pol4 activity during NHEJ...
  56. Hwang J, Smith S, Ceschia A, Torres Rosell J, Aragon L, Myung K. Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair (Amst). 2008;7:1426-36 pubmed publisher
  57. Balogun F, Truman A, Kron S. DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA Repair (Amst). 2013;12:751-60 pubmed publisher
    ..Together, these results implicate DNA resection, which is thought to be minimal in G1, as necessary for activation of the G1 checkpoint...
  58. Banerjee S, Myung K. Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints. Eukaryot Cell. 2004;3:1557-66 pubmed
    ..length caused by the elg1Delta mutation was suppressed by a defect in the DNA replication checkpoint, which suggests that DNA replication surveillance by Dpb11-Mec1/Tel1-Dun1 also has an important role in telomere length regulation.
  59. Javaheri A, Wysocki R, Jobin Robitaille O, Altaf M, Cote J, Kron S. Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci U S A. 2006;103:13771-6 pubmed
    ..Histone H2A (yeast H2AX) is rapidly phosphorylated on S129 by the kinase Tel1 (ATM) over a domain extending kilobases from the DSB...
  60. Mantiero D, Clerici M, Lucchini G, Longhese M. Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks. EMBO Rep. 2007;8:380-7 pubmed
    ..Here, we show that Saccharomyces cerevisiae Tel1, the ATM orthologue, has two functions in checkpoint response to DSBs...
  61. Torres Machorro A, Aris J, Pillus L. A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Res. 2015;43:1646-58 pubmed publisher
    ..This study improves understanding of the evolutionary, structural and biological relevance of independent activities in a moonlighting protein and links metabolism to DNA damage repair. ..
  62. Wanrooij P, Tannous E, Kumar S, Navadgi Patil V, Burgers P. Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides. J Biol Chem. 2016;291:393-401 pubmed publisher
  63. Blitzblau H, Hochwagen A. ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast. elife. 2013;2:e00844 pubmed publisher
    ..DOI: ..