TEC1

Summary

Gene Symbol: TEC1
Description: Tec1p
Alias: ROC1, Tec1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Chou S, Lane S, Liu H. Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol. 2006;26:4794-805 pubmed
    ..elements [PREs]), whereas filamentation genes are supposedly regulated by the cooperative binding of Ste12 and Tec1 on a PRE adjacent to a Tec1-binding site (TCS), termed filamentous responsive element (FRE)...
  2. Chou S, Huang L, Liu H. Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast. Cell. 2004;119:981-90 pubmed
    ..How Fus3 prevents the crossactivation is not clear. Here we show that Tec1, a cofactor of Ste12 for the expression of filamentation genes, is rapidly degraded during pheromone response...
  3. Shock T, Thompson J, Yates J, Madhani H. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryot Cell. 2009;8:606-16 pubmed publisher
    ..between the mating and FG pathways because mating signaling induces the destruction of the FG transcription factor Tec1. We show here that HOG pathway activation results in phosphorylation of the FG MAPK, Kss1, and the MAPKK, Ste7...
  4. Mösch H, Kübler E, Krappmann S, Fink G, Braus G. Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae. Mol Biol Cell. 1999;10:1325-35 pubmed
    ..of the filamentation response element-driven reporter gene depending on the transcription factors Ste12p and Tec1p, indicating a crosstalk between the MAPK and the cAMP signaling pathways in haploid cells during invasive growth.
  5. van Dyk D, Pretorius I, Bauer F. Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae. Genetics. 2005;169:91-106 pubmed
    ..been shown to affect FLO11 expression, including the signaling proteins Ras2p, Kss1p, and Tpk2p, the activators Tec1p, Flo8p, and Phd1p, and the repressors Nrg1p, Nrg2p, Sok2p, and Sfl1p...
  6. Madhani H, Fink G. Combinatorial control required for the specificity of yeast MAPK signaling. Science. 1997;275:1314-7 pubmed
    ..Developmental specificity was found to require a transcription factor of the TEA/ATTS family, Tec1, which cooperates with Ste12 during filamentous and invasive growth...
  7. Furukawa K, Sidoux Walter F, Hohmann S. Expression of the yeast aquaporin Aqy2 affects cell surface properties under the control of osmoregulatory and morphogenic signalling pathways. Mol Microbiol. 2009;74:1272-86 pubmed publisher
    ..Our observations suggest a potential link between aquaporins and cell surface properties, and relate to the proposed role of mammalian aquaporins in tumour cell migration and invasion. ..
  8. Lorenz M, Heitman J. Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics. 1998;150:1443-57 pubmed
    ..Multicopy expression of TEC1, PHD1, PHD2 (MSS10/MSN1/FUP4), MSN5, CDC6, MSS11, MGA1, SKN7, DOT6, HMS1, HMS2, or MEP2 each restored filamentation ..
  9. Bruckner S, Köhler T, Braus G, Heise B, Bolte M, Mösch H. Differential regulation of Tec1 by Fus3 and Kss1 confers signaling specificity in yeast development. Curr Genet. 2004;46:331-42 pubmed
    ..whether signal-specific activation of mating and invasive growth involves regulation of the transcription factor Tec1 by Fus3 and Kss1...

More Information

Publications36

  1. Bao M, Schwartz M, Cantin G, Yates J, Madhani H. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell. 2004;119:991-1000 pubmed
    ..Here we show that pheromone signaling induces Fus3-dependent degradation of Tec1, the transcription factor specific to the filamentation pathway...
  2. Wang Y, Dohlman H. Pheromone-regulated sumoylation of transcription factors that mediate the invasive to mating developmental switch in yeast. J Biol Chem. 2006;281:1964-9 pubmed
    ..Whereas Ste12-Ste12 homodimers promote transcription of genes required for mating, Ste12-Tec1 heterodimers activate genes required for invasive growth...
  3. Baur M, Esch R, Errede B. Cooperative binding interactions required for function of the Ty1 sterile responsive element. Mol Cell Biol. 1997;17:4330-7 pubmed
    ..Other experiments show that Tec1p is required for formation of the Ty1 SRE protein-DNA complex and is physically present in the complex...
  4. Pan X, Heitman J. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:4874-87 pubmed
    ..Activation of filamentous growth by PKA does not require the transcription factors Ste12 and Tec1 of the MAP kinase cascade, Phd1, or the PKA targets Msn2 and Msn4...
  5. van der Felden J, Weisser S, Bruckner S, Lenz P, Mösch H. The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. Mol Cell Biol. 2014;34:2283-93 pubmed publisher
    In Saccharomyces cerevisiae and related yeast species, the TEA transcription factor Tec1, together with a second transcription factor, Ste12, controls development, including cell adhesion and filament formation...
  6. La Valle R, Wittenberg C. A role for the Swe1 checkpoint kinase during filamentous growth of Saccharomyces cerevisiae. Genetics. 2001;158:549-62 pubmed
    ..Swe1 is also required for pseudohyphal growth in the absence of Tec1 and for the induction of filamentation by butanol, a related phenomenon...
  7. Bruckner S, Kern S, Birke R, Saugar I, Ulrich H, Mösch H. The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics. 2011;189:479-94 pubmed publisher
    In Saccharomyces cerevisiae, the TEA transcription factor Tec1 controls several developmental programs in response to nutrients and pheromones...
  8. Conte D, Curcio M. Fus3 controls Ty1 transpositional dormancy through the invasive growth MAPK pathway. Mol Microbiol. 2000;35:415-27 pubmed
    ..growth pathway, we show by epistatic analysis that the invasive growth pathway transcription factors Ste12 and Tec1 are both required for Fus3-mediated inhibition of Ty1 transposition...
  9. Köhler T, Wesche S, Taheri N, Braus G, Mösch H. Dual role of the Saccharomyces cerevisiae TEA/ATTS family transcription factor Tec1p in regulation of gene expression and cellular development. Eukaryot Cell. 2002;1:673-86 pubmed
    In Saccharomyces cerevisiae, the transcription factors Tec1p and Ste12p are required for haploid invasive and diploid pseudohyphal growth...
  10. Houser J, Ford E, Nagiec M, Errede B, Elston T. Positive roles for negative regulators in the mating response of yeast. Mol Syst Biol. 2012;8:586 pubmed publisher
    ..This mechanism allows the transcriptional response to act on a shorter time scale than upstream pathway activity. ..
  11. Bester M, Jacobson D, Bauer F. Many Saccharomyces cerevisiae Cell Wall Protein Encoding Genes Are Coregulated by Mss11, but Cellular Adhesion Phenotypes Appear Only Flo Protein Dependent. G3 (Bethesda). 2012;2:131-41 pubmed publisher
    ..This analysis shows that only FLO genes, in particular FLO1/10/11, appear to significantly impact on such phenotypes. Thus adhesion-related phenotypes are primarily dependent on the balance of FLO gene expression. ..
  12. Torbensen R, Møller H, Gresham D, Alizadeh S, Ochmann D, Boles E, et al. Amino acid transporter genes are essential for FLO11-dependent and FLO11-independent biofilm formation and invasive growth in Saccharomyces cerevisiae. PLoS ONE. 2012;7:e41272 pubmed publisher
    ..Increased intracellular amino acid pools in the PTR3(647::CWNKNPLSSIN)-containing strain opens the possibility that Gap1 regulates the FLO genes through alteration of the amino acid pool sizes. ..
  13. Aristizabal M, Negri G, Kobor M. The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition. PLoS Genet. 2015;11:e1005608 pubmed publisher
    ..Loss of STE12 and TEC1 suppressed growth phenotypes of the RNAPII-CTD truncation mutant...
  14. Chou S, Zhao S, Song Y, Liu H, Nie Q. Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response. Mol Syst Biol. 2008;4:212 pubmed publisher
    ..by the Ste12/Dig1/Dig2 complex through Ste12-binding sites, whereas filamentation genes are regulated by the Tec1/Ste12/Dig1 complex through Tec1-binding sites. The two Ste12 complexes are mutually exclusive...
  15. Wang Y, Abu Irqeba A, Ayalew M, Suntay K. Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. PLoS ONE. 2009;4:e7456 pubmed publisher
    b>Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells...
  16. Gavrias V, Andrianopoulos A, Gimeno C, Timberlake W. Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol Microbiol. 1996;19:1255-63 pubmed
    ..The S. cerevisiae homologue of AbaA, TEC1p, is required for this morphological transition...
  17. Madhani H, Galitski T, Lander E, Fink G. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc Natl Acad Sci U S A. 1999;96:12530-5 pubmed
    ..Thus, the Kss1 MAPK cascade programs development by coordinately modulating a cell adhesion factor, a secreted host-destroying activity, and a specialized subunit of the Cdc28 cyclin-dependent kinase. ..
  18. Chen R, Thorner J. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics. 2010;185:855-70 pubmed publisher
    ..Thus, although there are similarities between haploids and diploids, cell type-specific differences clearly alter the balance of the signaling inputs required to elicit the various nutrient limitation-evoked cellular behaviors. ..
  19. Su T, Tamarkina E, Sadowski I. Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae. FEBS J. 2010;277:3235-48 pubmed publisher
  20. Bao M, Shock T, Madhani H. Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo. Eukaryot Cell. 2010;9:31-6 pubmed publisher
    ..cerevisiae, the pheromone-induced ubiquitylation and degradation of the filamentation pathway-specific activator, Tec1, suppresses cross talk between the mating and filamentous growth mitogen-activated protein kinase (MAPK) pathways...
  21. Mösch H, Fink G. Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics. 1997;145:671-84 pubmed
    ..novel targets of the filamentation signaling pathway, and we thereby identified 16 different genes, CDC39, STE12, TEC1, WHI3, NAB1, DBR1, CDC55, SRV2, TPM1, SPA2, BNI1, DFG5, DFG9, DFG10, BUD8 and DFG16, mutations that block ..
  22. Kim T, Kim H, Yoon J, Kang H. Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression. Mol Cell Biol. 2004;24:9542-56 pubmed
    ..encodes an extracellular glucoamylase, is activated by the specific DNA-binding activators Flo8, Mss11, Ste12, and Tec1 and the Swi/Snf chromatin-remodeling complex...
  23. Ryan O, Shapiro R, Kurat C, Mayhew D, Baryshnikova A, Chin B, et al. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012;337:1353-6 pubmed publisher
    ..cerevisiae and C. albicans. ..
  24. Hurst J, Dohlman H. Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. J Biol Chem. 2013;288:18660-71 pubmed publisher
    ..These results reveal a feedback loop wherein one MAPK limits the ubiquitination of an upstream MAPKK and thereby prevents spurious activation of a second competing MAPK. ..
  25. Law M, Ciccaglione K. Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II. Genetics. 2015;199:435-53 pubmed publisher
    ..Interestingly, deleting known FLO11 activators including FLO8, MSS11, MFG1, TEC1, SNF1, KSS1, and GCN4 results in a range of phenotypic suppression...
  26. Kim J, Rose M. Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling. PLoS Genet. 2015;11:e1005684 pubmed publisher
    ..Taken together, our findings show that budding yeast can access a stable constitutive pseudohyphal growth state with very few genetic and regulatory changes. ..
  27. Heise B, van der Felden J, Kern S, Malcher M, Bruckner S, Mösch H. The TEA transcription factor Tec1 confers promoter-specific gene regulation by Ste12-dependent and -independent mechanisms. Eukaryot Cell. 2010;9:514-31 pubmed publisher
    In Saccharomyces cerevisiae, the TEA transcription factor Tec1 is known to regulate target genes together with a second transcription factor, Ste12...