Gene Symbol: TAM41
Description: putative phosphatidate cytidylyltransferase
Species: Saccharomyces cerevisiae S288c
Gallas M, Dienhart M, Stuart R, Long R. Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import. Mol Biol Cell. 2006;17:4051-62 pubmed
..Haploid cells deleted of MMP37 are viable but display a temperature-sensitive growth phenotype and are inviable in the absence of mitochondrial ..
Tamura Y, Harada Y, Yamano K, Watanabe K, Ishikawa D, Ohshima C, et al
. Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria. J Cell Biol. 2006;174:631-7 pubmed
..We report the identification of yeast Tam41, a new member of mitochondrial protein translocator systems...
Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, et al
. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab. 2013;17:709-18 pubmed publisher
..yeast Saccharomyces cerevisiae as a model organism that Cds1 resides in the ER but not in mitochondria, and that Tam41, a highly conserved mitochondrial maintenance protein, directly catalyzes the formation of CDP-DAG from PA in the ..
Pareek G, Krishnamoorthy V, D Silva P. Molecular insights revealing interaction of Tim23 and channel subunits of presequence translocase. Mol Cell Biol. 2013;33:4641-59 pubmed publisher
..Our model conceptually explains the cooperative function between Tam41 and Pam17 subunits, while the antagonistic activity of Tim21 predominantly determines the bound and free forms of ..
Kutik S, Rissler M, Guan X, Guiard B, Shui G, Gebert N, et al
. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol. 2008;183:1213-21 pubmed publisher
..The translocator assembly and maintenance protein 41 (Tam41/mitochondrial matrix protein 37) was identified as a new member of the mitochondrial protein translocator systems ..
Harada Y, Tamura Y, Endo T. Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41. Biochem Biophys Res Commun. 2010;392:228-33 pubmed publisher
..b>Tam41 is a peripheral inner membrane protein that is involved in the structural maintenance of the inner membrane ..
Osman C, Haag M, Wieland F, Brugger B, Langer T. A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 2010;29:1976-87 pubmed publisher
..Gep4 in the CL-biosynthetic pathway and assign an essential function during early steps of CL synthesis to Tam41, which has previously been shown to be essential for the maintenance of normal CL levels...
Connerth M, Tatsuta T, Haag M, Klecker T, Westermann B, Langer T. Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein. Science. 2012;338:815-8 pubmed publisher
..Thus, intramitochondrial lipid trafficking may involve a regulatory feedback mechanism that limits the accumulation of cardiolipin in mitochondria. ..