Gene Symbol: TAH18
Description: NAPDH-dependent diflavin reductase
Alias: NAPDH-dependent diflavin reductase
Species: Saccharomyces cerevisiae S288c
Chanet R, Heude M. Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet. 2003;43:337-50 pubmed
..Finally, mutations in three genes of unknown function were isolated (NBP35, DRE2, TAH18)...
Vernis L, Facca C, Delagoutte E, Soler N, Chanet R, Guiard B, et al
. A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS ONE. 2009;4:e4376 pubmed publisher
A mutated allele of the essential gene TAH18 was previously identified in our laboratory in a genetic screen for new proteins interacting with the DNA polymerase delta in yeast ...
Soler N, Delagoutte E, Miron S, Facca C, Baïlle D, D Autréaux B, et al
. Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Mol Microbiol. 2011;82:54-67 pubmed publisher
b>Tah18-Dre2 is a recently identified yeast protein complex, which is highly conserved in human and has been implicated in the regulation of oxidative stress induced cell death and in cytosolic Fe-S proteins synthesis...
Nishimura A, Kawahara N, Takagi H. The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells. Biochem Biophys Res Commun. 2013;430:137-43 pubmed publisher
..We also showed that the flavoprotein Tah18, which was previously reported to transfer electrons to the Fe-S cluster protein Dre2, was involved in NO ..
Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher
..Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches ..
Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, et al
. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014;111:E1695-704 pubmed publisher
..Here, we demonstrate that the conserved Fe-S protein-diflavin reductase complex, Dre2-Tah18, plays a critical role in RNR cofactor biosynthesis...
Yoshikawa Y, Nasuno R, Kawahara N, Nishimura A, Watanabe D, Takagi H. Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast. Nitric Oxide. 2016;57:85-91 pubmed publisher
..Recently, we reported that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like ..
Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, et al
. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017;292:11445-11451 pubmed publisher
..from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation ..