Gene Symbol: TAH1
Description: Tah1p
Alias: Tah1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Millson S, Vaughan C, Zhai C, Ali M, Panaretou B, Piper P, et al. Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochem J. 2008;413:261-8 pubmed publisher
    b>Tah1 [TPR (tetratricopeptide repeat)-containing protein associated with Hsp (heat-shock protein) 90] has been identified as a TPR-domain protein...
  2. Eckert K, Saliou J, Monlezun L, Vigouroux A, Atmane N, Caillat C, et al. The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem. 2010;285:31304-12 pubmed publisher
    ..TPR (TetratricoPeptide Repeat)-containing protein associated with Hsp90 (Tah1) and protein interacting with Hsp90 (Pih1) have been identified in Saccharomyces cerevisiae as two Hsp90 ..
  3. Pal M, Morgan M, Phelps S, Roe S, Parry Morris S, Downs J, et al. Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure. 2014;22:805-18 pubmed publisher
    ..complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90...
  4. Boulon S, Marmier Gourrier N, Pradet Balade B, Wurth L, Verheggen C, Jady B, et al. The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol. 2008;180:579-95 pubmed publisher
    ..the AAA + adenosine triphosphatases hRvb1 and hRvb2 and with the Hsp90 chaperone through two conserved adaptors, Tah1/hSpagh and Pih1...
  5. Jimenez B, Ugwu F, Zhao R, Ortí L, Makhnevych T, Pineda Lucena A, et al. Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90. J Biol Chem. 2012;287:5698-709 pubmed publisher
    b>Tah1 and Pih1 are novel Hsp90 interactors. Tah1 acts as a cofactor of Hsp90 to stabilize Pih1...
  6. Paci A, Liu X, Huang H, Lim A, Houry W, Zhao R. The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus. J Biol Chem. 2012;287:43205-14 pubmed publisher
    ..complex that, in yeast Saccharomyces cerevisiae, also contains the helicases Rvb1, Rvb2, and the Hsp90 cofactor Tah1. Pih1 and the R2TP complex are required for the box C/D small nucleolar ribonucleoprotein (snoRNP) assembly and ..
  7. Back R, Dominguez C, Rothé B, Bobo C, Beaufils C, Morera S, et al. High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex. Structure. 2013;21:1834-47 pubmed publisher
    ..This complex includes the proteins Tah1, Pih1, Rvb1, and Rvb2. Tah1 bridges Hsp90 to R2TP...
  8. Jacobson M, Muñoz C, Knox K, Williams B, Lu L, Cross F, et al. Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase. Genetics. 2001;159:17-33 pubmed
    ..Consistent with this hypothesis, sid2-1 rad9 cells are dead or very slow growing even when SIC1 is expressed. ..
  9. Cheung K, Huen J, Kakihara Y, Houry W, Ortega J. Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags. J Mol Biol. 2010;404:478-92 pubmed publisher
    ..These results demonstrate that some of the differences between the reported structures are caused by histidine tags and imply that further studies on the purified proteins should be carried out using untagged constructs. ..

More Information


  1. Rothé B, Saliou J, Quinternet M, Back R, Tiotiu D, Jacquemin C, et al. Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. Nucleic Acids Res. 2014;42:10731-47 pubmed publisher
    ..Our biochemical data show that C/D snoRNAs and the core protein Nop58 can interact with the purified Snu13p-Rsa1p-Hit1p heterotrimer. ..
  2. Lancaster D, Dobson C, Rachubinski R. Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae. J Biol Chem. 2013;288:1266-76 pubmed publisher
    ..Together, our results demonstrate a role for chaperones in regulating the prion variant complement of a cell. ..
  3. Morgan R, Pal M, Roe S, Pearl L, Prodromou C. Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallogr D Biol Crystallogr. 2015;71:1197-206 pubmed publisher
    Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their ..
  4. Johnson J, Zuehlke A, Tenge V, Langworthy J. Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones. Curr Genet. 2014;60:265-76 pubmed publisher
    ..This provides new evidence that co-chaperones selectively compete for binding to subpopulations of cellular Hsp90 and suggest that changes in the relative levels of co-chaperones may have dramatic effects on Hsp90 function. ..
  5. Kakihara Y, Makhnevych T, Zhao L, Tang W, Houry W. Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex. Genome Biol. 2014;15:404 pubmed publisher
    ..The highly conserved R2TP complex, comprising the proteins Rvb1, Rvb2, Tah1, and Pih1, has been shown to be required for box C/D snoRNP biogenesis and assembly; however, the molecular basis ..
  6. Manival X, Jacquemin C, Charpentier B, Quinternet M. (1)H, (15)N and (13)C resonance assignments of the yeast Pih1 and Tah1 C-terminal domains complex. Biomol NMR Assign. 2015;9:71-3 pubmed publisher
    We report the nearly complete (1)H, (15)N and (13)C resonance assignment of the complex formed by the C-terminal domains of Pih1 and Tah1 from S. cerevisiae and evidence the folding ability of Tah1 under complex formation.
  7. Quinternet M, Rothé B, Barbier M, Bobo C, Saliou J, Jacquemin C, et al. Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. J Mol Biol. 2015;427:2816-39 pubmed publisher
    ..HUMAN/Yeast) BCD1/Bcd1p, NUFIP1/Rsa1p, ZNHIT3/Hit1p, the R2TP complex composed of protein PIH1D1/Pih1p and RPAP3/Tah1p that bridges the R2TP complex to the HSP90/Hsp82 chaperone and two AAA+ ATPases...
  8. Tian S, Yu G, He H, Zhao Y, Liu P, Marshall A, et al. Pih1p-Tah1p Puts a Lid on Hexameric AAA+ ATPases Rvb1/2p. Structure. 2017;25:1519-1529.e4 pubmed publisher
    ..the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p, and two Hsp90 binding proteins, Tah1p and Pih1p, and its interaction with the snoRNP protein Nop58p by a combination of analytical ultracentrifugation, ..