TAF3

Summary

Gene Symbol: TAF3
Description: Taf3p
Alias: TAF47, Taf3p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Papai G, Tripathi M, Ruhlmann C, Werten S, Crucifix C, Weil P, et al. Mapping the initiator binding Taf2 subunit in the structure of hydrated yeast TFIID. Structure. 2009;17:363-73 pubmed publisher
    ..Mapping the position of this crucial subunit in the vicinity of Taf1p and of TBP sheds new light on its role in promoter recognition. ..
  2. Takahata S, Kasahara K, Kawaichi M, Kokubo T. Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation. Mol Cell Biol. 2004;24:3089-99 pubmed
    ..These results indicate that there is no or minimal geometric constraint on the ability of the TAND to function normally in transcriptional regulation as long as TFIID assembly is secured. ..
  3. Irvin J, Pugh B. Genome-wide transcriptional dependence on TAF1 functional domains. J Biol Chem. 2006;281:6404-12 pubmed
  4. Kirschner D, vom Baur E, Thibault C, Sanders S, Gangloff Y, Davidson I, et al. Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns. Mol Cell Biol. 2002;22:3178-93 pubmed
    ..Thus, different yTAF(II)25 mutations induce distinct phenotypes and affect the regulation of different subsets of genes, demonstrating that no individual TAF(II) mutant allele reflects the full range of its normal functions. ..
  5. Garbett K, Tripathi M, Cencki B, Layer J, Weil P. Yeast TFIID serves as a coactivator for Rap1p by direct protein-protein interaction. Mol Cell Biol. 2007;27:297-311 pubmed
    ..We conclude that Rap1p and TFIID directly interact and that this interaction contributes importantly to RP gene transcription. ..
  6. Gangloff Y, Sanders S, Romier C, Kirschner D, Weil P, Tora L, et al. Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7. Mol Cell Biol. 2001;21:1841-53 pubmed
    ..Furthermore, our results indicate that ySPT7 has an HFD homologous to that of yTAF(II)47 which selectively heterodimerizes with yTAF(II)25, defining a novel histone-like pair in the SAGA complex. ..
  7. Leurent C, Sanders S, Ruhlmann C, Mallouh V, Weil P, Kirschner D, et al. Mapping histone fold TAFs within yeast TFIID. EMBO J. 2002;21:3424-33 pubmed
    ..Most of the HFD-containing TAFs have been found in two distinct lobes, thus revealing an unexpected and novel molecular organization of TFIID. ..
  8. James N, Landrieux E, Collart M. A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae. Genetics. 2007;177:123-35 pubmed
    ..Taken together, our results provide a new view of the Spt3 protein by identifying a SAGA-independent function of this protein that is functionally linked to the Ccr4-Not complex. ..
  9. Sanders S, Weil P. Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex. J Biol Chem. 2000;275:13895-900 pubmed
    ..TAF complexes. The significance of these results in terms of TFIID structure, function, and organization is discussed. ..

More Information

Publications17

  1. Deluen C, James N, Maillet L, Molinete M, Theiler G, Lemaire M, et al. The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions. Mol Cell Biol. 2002;22:6735-49 pubmed
  2. Sanders S, Garbett K, Weil P. Molecular characterization of Saccharomyces cerevisiae TFIID. Mol Cell Biol. 2002;22:6000-13 pubmed
    ..The results of direct biochemical exchange experiments confirmed this hypothesis. Together, our results represent a concise molecular characterization of the general transcription factor TFIID from S. cerevisiae. ..
  3. Ohtsuki K, Kasahara K, Shirahige K, Kokubo T. Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters. Nucleic Acids Res. 2010;38:1805-20 pubmed publisher
  4. Chimura T, Kuzuhara T, Horikoshi M. Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID. Proc Natl Acad Sci U S A. 2002;99:9334-9 pubmed
    ..This study describes the functional linkage between TFIID and a histone chaperone. ..
  5. Kirchner J, Sanders S, Klebanow E, Weil P. Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors. Mol Cell Biol. 2001;21:6668-80 pubmed
    ..The results of these analyses show that TAF25p is comprised of multiple mutable elements which contribute importantly to RNA polymerase II-mediated mRNA gene transcription. ..
  6. Mencia M, Struhl K. Region of yeast TAF 130 required for TFIID to associate with promoters. Mol Cell Biol. 2001;21:1145-54 pubmed
    ..These results suggest that the C-terminal region of TAF130 is required for TFIID to associate with promoters. ..
  7. Auty R, Steen H, Myers L, Persinger J, Bartholomew B, Gygi S, et al. Purification of active TFIID from Saccharomyces cerevisiae. Extensive promoter contacts and co-activator function. J Biol Chem. 2004;279:49973-81 pubmed
    ..TFIID supports basal transcription and activated transcription, both of which are enhanced by TFIIA. ..
  8. Durso R, Fisher A, Albright Frey T, Reese J. Analysis of TAF90 mutants displaying allele-specific and broad defects in transcription. Mol Cell Biol. 2001;21:7331-44 pubmed