Gene Symbol: SYN8
Alias: SLT2, UIP2, syntaxin
Species: Saccharomyces cerevisiae S288c
Kucharczyk R, Hoffman Sommer M, Piekarska I, von Mollard G, Rytka J. The Saccharomyces cerevisiae protein Ccz1p interacts with components of the endosomal fusion machinery. FEMS Yeast Res. 2009;9:565-73 pubmed publisher
..The genes MON1 and YPT7 also interact genetically with PEP12. These results suggest that the Ccz1p-Mon1p-Ypt7p complex is involved in fusion of transport vesicles to multiple target membranes in yeast cells. ..
Lewis M, Pelham H. A new yeast endosomal SNARE related to mammalian syntaxin 8. Traffic. 2002;3:922-9 pubmed
..It is encoded by an extended version of ORF YAL014c, and since its SNARE motif is related to mammalian syntaxin 8 we term the gene SYN8. Syn8p is in endosomes...
Izawa R, Onoue T, Furukawa N, Mima J. Distinct contributions of vacuolar Qabc- and R-SNARE proteins to membrane fusion specificity. J Biol Chem. 2012;287:3445-53 pubmed publisher
..Thus, our current study establishes that an appropriate assembly of Qabc-SNAREs is crucial for regulating fusion specificity, whereas R-SNARE itself has little contribution to specificity. ..
Venturi G, Bloecher A, Williams Hart T, Tatchell K. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Genetics. 2000;155:69-83 pubmed
..Together our data suggest that Ppz1p and Ppz2p may have overlapping functions with Glc7p and that all three phosphatases may act through common regulatory proteins. ..
Zimmermann J, Chidambaram S, Fischer von Mollard G. Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes. Biochem J. 2010;431:123-34 pubmed publisher
..This provides the necessary flexibility to bind three SNAREs with little sequence homology but maintains the specificity of the interaction. ..
Tu J, Song W, Carlson M. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:4199-206 pubmed
..In addition, this study indicates that the two-hybrid system offers a promising approach to understanding the multiple roles and interactions of PP1 in cellular regulation. ..
Gossing M, Chidambaram S, Fischer von Mollard G. Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system. PLoS ONE. 2013;8:e66304 pubmed publisher
..As different transport steps were affected our data demonstrate the importance of a folded Vti1p H(abc) domain for transport. ..