Gene Symbol: SXM1
Alias: KAP108, Sxm1p
Species: Saccharomyces cerevisiae S288c
Seedorf M, Silver P. Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A. 1997;94:8590-5 pubmed
..Overexpression of Sxm1p, a protein related to Cse1p in yeast and to the human cellular apoptosis susceptibility protein, relieves the ..
Rosenblum J, Pemberton L, Blobel G. A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol. 1997;139:1655-61 pubmed
..From yeast cytosol, we isolated Sxm1p in complex with several potential import substrates...
Brune C, Munchel S, Fischer N, Podtelejnikov A, Weis K. Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA. 2005;11:517-31 pubmed
..Import of Pab1 is mediated by the import receptor Kap108/Sxm1 through a nuclear localization signal in its fourth RNA-binding domain...
Calvert M, Keck K, Ptak C, Shabanowitz J, Hunt D, Pemberton L. Phosphorylation by casein kinase 2 regulates Nap1 localization and function. Mol Cell Biol. 2008;28:1313-25 pubmed
..In conclusion, our data show that Nap1 phosphorylation by CK2 appears to regulate Nap1 localization and is required for normal progression through S phase. ..
Yao Y, Demoinet E, Saveanu C, Lenormand P, Jacquier A, Fromont Racine M. Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export. RNA. 2010;16:1007-17 pubmed publisher
..These data highlight the involvement of many factors acting together to export pre-60S particles. ..
Hahn S, Schlenstedt G. Importin ?-type nuclear transport receptors have distinct binding affinities for Ran-GTP. Biochem Biophys Res Commun. 2011;406:383-8 pubmed publisher
..We found that the number of ?-receptors altogether about equals the amounts of yeast Ran, but Ran-GTP is not limiting in the nucleus. The implications of our results for nucleocytoplasmic transport mechanisms are discussed. ..
Rosenblum J, Pemberton L, Bonifaci N, Blobel G. Nuclear import and the evolution of a multifunctional RNA-binding protein. J Cell Biol. 1998;143:887-99 pubmed
..cerevisiae La, Lhp1p. The soluble transport factor, or karyopherin, that mediates the import of Lhp1p is Kap108p/Sxm1p. We have now determined a 113-amino acid domain of Lhp1p that is brought to the nucleus by Kap108p...
Fries T, Betz C, Sohn K, Caesar S, Schlenstedt G, Bailer S. A novel conserved nuclear localization signal is recognized by a group of yeast importins. J Biol Chem. 2007;282:19292-301 pubmed
Süel K, Chook Y. Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. J Biol Chem. 2009;284:15416-24 pubmed publisher
..More generally, steady-state localization of a nuclear protein is dictated by its nuclear import and export activities as well as its interactions in the nucleus and the cytoplasm. ..