SWI5

Summary

Gene Symbol: SWI5
Description: Swi5p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
    M P Cosma
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 97:299-311. 1999
  2. pmc The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase
    J H Toyn
    Division of Yeast Genetics, National Institute for Medical Research, London, United Kingdom
    Genetics 145:85-96. 1997
  3. ncbi Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation
    H J McBride
    Division of Molecular Biology and Genetics, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Biol Chem 274:21029-36. 1999
  4. pmc The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1
    D Knapp
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 16:5701-7. 1996
  5. pmc Forkhead proteins control the outcome of transcription factor binding by antiactivation
    Warren P Voth
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    EMBO J 26:4324-34. 2007
  6. ncbi The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
    R Visintin
    Whitehead Institute for Biomedical Research, Cambridge Center, Massachusetts 02142, USA
    Mol Cell 2:709-18. 1998
  7. pmc Multisite phosphorylation networks as signal processors for Cdk1
    Mardo Kõivomägi
    Institute of Technology, University of Tartu, Tartu, Estonia
    Nat Struct Mol Biol 20:1415-24. 2013
  8. doi Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5
    Francisco José Taberner
    Deparament de Bioquimica i Biologia Molecular, Universitat de Valencia, Valencia, Spain
    Biochim Biophys Acta 1823:959-70. 2012
  9. pmc Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene
    D J Stillman
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 7:485-94. 1988
  10. pmc A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS Biol 11:e1001495. 2013

Research Grants

  1. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2006
  2. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2007
  3. Sources and Consequences of noise in cell cycle regulation
    FREDERICK CROSS; Fiscal Year: 2007
  4. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2009
  5. Sources and Consequences of noise in cell cycle regulation
    FREDERICK CROSS; Fiscal Year: 2009
  6. CONTROL OF THE START OF THE BUDDING YEAST CELL CYCLE
    FREDERICK CROSS; Fiscal Year: 1993
  7. SPECIFICITY OF CYCLIN FUNCTION AT CELL CYCLE INITIATION
    FREDERICK CROSS; Fiscal Year: 2002
  8. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2003
  9. How do cyclins drive the cell cycle?
    Frederick R Cross; Fiscal Year: 2010

Scientific Experts

  • M E Dresser
  • Mads Kaern
  • FREDERICK CROSS
  • Tsutomu Kishi
  • D J Stillman
  • Warren P Voth
  • Y Yu
  • Shinya Takahata
  • David J Stillman
  • Franz Meitinger
  • Mardo Kõivomägi
  • Francisco José Taberner
  • L T Bhoite
  • Cory Batenchuk
  • M P Cosma
  • Stefano Di Talia
  • Silvia Hahn
  • Yaxin Yu
  • K Nasmyth
  • H J McBride
  • R M Brazas
  • Vincent Archambault
  • Kristen E Neely
  • Mihkel Ord
  • Heidi Richter
  • Ilona Faustova
  • Anna Iofik
  • Rait Kivi
  • Gislene Pereira
  • Birgit Hub
  • Wolfgang Seufert
  • Seth M Rubin
  • Ervin Valk
  • Rainis Venta
  • Eva Rose M Balog
  • Sabrina Heisel
  • Mart Loog
  • J H Toyn
  • Juan Carlos Igual
  • Inma Quilis
  • María Carmen Bañó
  • Josep Sendra
  • Lioudmila Tepliakova
  • V Measday
  • J E Krebs
  • Hongyin Wang
  • Bruce Futcher
  • Jan M Skotheim
  • Adam P Rosebrock
  • S Zhang
  • Patrick Maurer
  • Gabriel Schlenstedt
  • K E Neely
  • Stefanie Caesar
  • Kelsi L Kretschmann
  • Jason D Lieb
  • Brett Milash
  • Rebecca L Parker
  • R Visintin
  • J Perez-Martin
  • B L Aerne
  • Mohammed Sbia
  • L H Johnston
  • Karen H Freedman
  • A L Johnson
  • Aileen E Olsen
  • Ralph Wasch
  • Michael P Rout
  • Alan J Tackett
  • Caihong X Li
  • Brian T Chait
  • LeAnn Howe
  • Christine E Brown
  • Ahmed H Hassan
  • Jerry L Workman
  • D Knapp
  • S Panizza
  • D Stillman
  • J Moffat
  • B Andrews
  • P Eriksson
  • H McBride
  • C J Fry
  • M L Samuels
  • C L Peterson
  • A E Wallberg
  • J L Workman
  • A P Wright
  • D J Garfinkel
  • Y Skalsky

Detail Information

Publications38

  1. ncbi Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
    M P Cosma
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 97:299-311. 1999
    ..Swi5p remains at HO for only 5 min. Swi/Snf's and SAGA's subsequent persistence at HO is self sustaining and constitutes an "epigenetic memory" of HO's transient interaction with Swi5p...
  2. pmc The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase
    J H Toyn
    Division of Yeast Genetics, National Institute for Medical Research, London, United Kingdom
    Genetics 145:85-96. 1997
    ..We show that the cell cycle timing of SIC1 expression depends on the transcription factor Swi5, and that Swi5-dependent SIC1 expression begins during telophase...
  3. ncbi Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation
    H J McBride
    Division of Molecular Biology and Genetics, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Biol Chem 274:21029-36. 1999
    b>Swi5 and Ace2 are cell cycle-regulated transcription factors that activate expression of early G(1)-specific genes in Saccharomyces cerevisiae...
  4. pmc The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1
    D Knapp
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 16:5701-7. 1996
    ..Mutations in three loci (SIC1, SWI5, and RIC3) were identified. We have shown that high SIC1 transcript levels at late M phase depend on Swi5...
  5. pmc Forkhead proteins control the outcome of transcription factor binding by antiactivation
    Warren P Voth
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    EMBO J 26:4324-34. 2007
    Transcription factors with identical DNA-binding specificity often activate different genes in vivo. Yeast Ace2 and Swi5 are such activators, with targets we classify as Swi5-only, Ace2-only, or both. We define two unique regulatory modes...
  6. ncbi The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
    R Visintin
    Whitehead Institute for Biomedical Research, Cambridge Center, Massachusetts 02142, USA
    Mol Cell 2:709-18. 1998
    ..Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the ..
  7. pmc Multisite phosphorylation networks as signal processors for Cdk1
    Mardo Kõivomägi
    Institute of Technology, University of Tartu, Tartu, Estonia
    Nat Struct Mol Biol 20:1415-24. 2013
    ....
  8. doi Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5
    Francisco José Taberner
    Deparament de Bioquimica i Biologia Molecular, Universitat de Valencia, Valencia, Spain
    Biochim Biophys Acta 1823:959-70. 2012
    ..We determined that Msn5 controlled subcellular localization of the mitotic exit transcription factor Swi5, since it was required for Swi5 nuclear export. Msn5 physically interacted with the N-terminal end of Swi5...
  9. pmc Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene
    D J Stillman
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 7:485-94. 1988
    ..It has been demonstrated that the SWI5 gene, which is an activator of HO expression, plays a critical role in this differential mother/daughter expression ..
  10. pmc A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS Biol 11:e1001495. 2013
    ..Our findings provide unexpected insights into the temporal control of cytokinesis and describe the importance of a Gps1-dependent mechanism for highly accurate polarity switching between two closely connected locations...
  11. pmc Transcription activator interactions with multiple SWI/SNF subunits
    Kristen E Neely
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Cell Biol 22:1615-25. 2002
    ..Thus, three distinct subunits of the SWI/SNF complex contribute to its interactions with activation domains...
  12. pmc The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II
    L T Bhoite
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Genes Dev 15:2457-69. 2001
    ..Binding of the early G1 transcription factor Swi5 to the distal URS1 element of the HO promoter initiates a cascade of events through recruitment of the Swi/Snf and ..
  13. pmc Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit
    Vincent Archambault
    The Rockefeller University, New York, New York 10021, USA
    Mol Biol Cell 14:4592-604. 2003
    ..We conclude, therefore, that although both Cdc6 and Sic1 have the potential to facilitate mitotic exit by inhibiting Clb2-Cdk, mitotic exit nevertheless does not require any identified stoichiometric inhibitor of Cdk activity...
  14. pmc ACE2, CBK1, and BUD4 in budding and cell separation
    Warren P Voth
    Department of Pathology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132 2501, USA
    Eukaryot Cell 4:1018-28. 2005
    ..b>SWI5 encodes a transcription factor paralogous to ACE2...
  15. pmc Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness
    Frederick R Cross
    The Rockefeller University, New York, New York 10021, USA
    Genetics 176:1541-55. 2007
    ....
  16. doi Classical NLS proteins from Saccharomyces cerevisiae
    Silvia Hahn
    Medizinische Biochemie und Molekularbiologie, Universitat des Saarlandes, Geb 61 4, 66421 Homburg, Germany
    J Mol Biol 379:678-94. 2008
    ..We show for the first time that endogenous S. cerevisiae proteins Prp20, Cdc6, Swi5, Cdc45, and Clb2 fulfill all of these criteria identifying them as authentic yeast cNLS cargos...
  17. pmc A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry
    Tsutomu Kishi
    Kishi Initiative Research Unit, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 105:14497-502. 2008
    ..system to allow screening Cdc4-substrate interactions under conditions of substrate stabilization, and identified Swi5 as a substrate of the SCF(Cdc4) complex...
  18. pmc FACT and Asf1 regulate nucleosome dynamics and coactivator binding at the HO promoter
    Shinya Takahata
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    Mol Cell 34:405-15. 2009
    ..The Swi/Snf, SAGA, and Mediator coactivators bind first to the far upstream promoter region and subsequently to a promoter proximal region, and FACT and Asf1 are both required for this coactivator re-recruitment...
  19. pmc Daughter-specific transcription factors regulate cell size control in budding yeast
    Stefano Di Talia
    The Rockefeller University, New York, New York, USA
    PLoS Biol 7:e1000221. 2009
    ..This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle...
  20. pmc Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis
    Cory Batenchuk
    Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    BMC Genomics 11:493. 2010
    ....
  21. ncbi Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF
    M P Cosma
    Research Institute of Molecular Pathology, A 1030, Vienna, Austria
    Mol Cell 7:1213-20. 2001
    ..The first is triggered by inactivation of Cdk1 at the end of mitosis, which promotes import into the nucleus of the Swi5 transcription factor...
  22. ncbi Global role for chromatin remodeling enzymes in mitotic gene expression
    J E Krebs
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Cell 102:587-98. 2000
    ..We propose that SWI/SNF and Gcn5p are globally required for mitotic gene expression due to the condensed state of mitotic chromatin...
  23. pmc Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription
    Y Yu
    Division of Molecular Biology and Genetics, Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Cell Biol 20:2350-7. 2000
    ..These studies underscore the critical role of chromatin structure in regulating HO gene expression...
  24. ncbi Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast
    K Nasmyth
    Cell 48:579-87. 1987
    ..characterization of mutations in two new genes called SDI1 and SDI2, which partially suppress the requirement for SWI5 and which cause daughter cells to express HO...
  25. ncbi Determining the requirements for cooperative DNA binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO promoter
    R M Brazas
    Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    J Biol Chem 270:29151-61. 1995
    ..These observations suggest that the interaction domains of Swi5p and Pho2p are flexible and can tolerate an increase in distance between the two binding sites. The mechanism of the cooperative DNA binding by Swi5p and Pho2p is discussed...
  26. pmc The Swi5 zinc-finger and Grf10 homeodomain proteins bind DNA cooperatively at the yeast HO promoter
    R M Brazas
    Department of Cellular, Viral, and Molecular Biology, University of Utah Medical Center, Salt Lake City 84132
    Proc Natl Acad Sci U S A 90:11237-41. 1993
    b>SWI5 encodes a zinc-finger protein required for expression of the yeast HO gene...
  27. pmc Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator
    D J Stillman
    Department of Cellular, Viral, and Molecular Biology, University of Utah Medical Center, Salt Lake City 84132
    Genetics 136:781-8. 1994
    ..We have also identified a new swi5 suppressor, RGR1. The RGR1 gene was identified originally as a negative regulator of SUC2...
  28. pmc Identification and purification of a protein that binds DNA cooperatively with the yeast SWI5 protein
    R M Brazas
    Department of Cellular, Viral, and Molecular Biology, University of Utah Medical Center, Salt Lake City 84132
    Mol Cell Biol 13:5524-37. 1993
    The Saccharomyces cerevisiae SWI5 gene encodes a zinc finger protein required for the expression of the HO gene. A protein fusion between glutathione S-transferase and SWI5 was expressed in Escherichia coli and purified...
  29. pmc Long-range interactions at the HO promoter
    H J McBride
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Mol Cell Biol 17:2669-78. 1997
    The SWI5 gene encodes a zinc finger DNA-binding protein required for the transcriptional activation of the yeast HO gene. There are two Swi5p binding sites in the HO promoter, site A at -1800 and site B at -1300...
  30. pmc DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway
    M E Dresser
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Genetics 147:533-44. 1997
    ..Interestingly, the pattern on CHEF gels of chromosome fragments that result from meiotic DNA double-strand break formation is different in DMC1 mutant strains from that seen in rad50S strains...
  31. pmc Swi5 controls a novel wave of cyclin synthesis in late mitosis
    B L Aerne
    Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Mol Biol Cell 9:945-56. 1998
    We have shown previously that the Swi5 transcription factor regulates the expression of the SIC1 Cdk inhibitor in late mitosis. This suggests that Swi5 might control other genes with roles in ending mitosis...
  32. pmc The C-terminal domain of Sin1 interacts with the SWI-SNF complex in yeast
    J Perez-Martin
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143 0414, USA
    Mol Cell Biol 18:4157-64. 1998
    ..Based on these and additional results, we propose that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome...
  33. pmc Residues in the Swi5 zinc finger protein that mediate cooperative DNA binding with the Pho2 homeodomain protein
    L T Bhoite
    Division of Molecular Biology and Genetics, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Cell Biol 18:6436-46. 1998
    The Swi5 zinc finger and the Pho2 homeodomain DNA-binding proteins bind cooperatively to the HO promoter. Pho2 (also known as Bas2 or Grf10) activates transcription of diverse genes, acting with multiple distinct DNA-binding proteins...
  34. pmc MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae
    S Zhang
    Movable Genetic Elements Section, Gene Regulation and Chromosome Biology Laboratory, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Genetics 151:473-83. 1999
    ..We have isolated a gene-specific activator, SWI5, and the Delta9 fatty acid desaturase of yeast, OLE1, as multicopy suppressors of an mga2Delta spt23 temperature-..
  35. ncbi Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
    K E Neely
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Mol Cell 4:649-55. 1999
    ..The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts...
  36. ncbi Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast
    V Measday
    Department of Molecular and Medical Genetics, University of Toronto, Rm 4285 Medical Sciences Building, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8
    Mol Microbiol 35:825-34. 2000
    ..Pcl2-Pho85, we performed a two-hybrid screen using the Pcl2 cyclin as bait and recovered the transcription factor Swi5 as a Pcl2-interacting protein...
  37. ncbi Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription
    L Breeden
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 5:1183-90. 1991
    ..High-level constitutive synthesis of SWI4 also suppresses swi5 and swi6 mutations, suggesting that SWI4 is the predominant activator of HO transcription and that mutations in ..

Research Grants20

  1. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2006
    ..This oscillator is highly conserved and essential for cell cycle control throughout the eukaryotes. ..
  2. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2007
    ..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..
  3. Sources and Consequences of noise in cell cycle regulation
    FREDERICK CROSS; Fiscal Year: 2007
    ....
  4. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2009
    ..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..
  5. Sources and Consequences of noise in cell cycle regulation
    FREDERICK CROSS; Fiscal Year: 2009
    ....
  6. CONTROL OF THE START OF THE BUDDING YEAST CELL CYCLE
    FREDERICK CROSS; Fiscal Year: 1993
    ..These are the issues addressed in this application...
  7. SPECIFICITY OF CYCLIN FUNCTION AT CELL CYCLE INITIATION
    FREDERICK CROSS; Fiscal Year: 2002
    ....
  8. How do cyclins drive the cell cycle?
    FREDERICK CROSS; Fiscal Year: 2003
    ..This oscillator is highly conserved and essential for cell cycle control throughout the eukaryotes. ..
  9. How do cyclins drive the cell cycle?
    Frederick R Cross; Fiscal Year: 2010
    ..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..