Gene Symbol: SWI4
Description: SBF complex DNA-binding subunit SWI4
Alias: ART1, SBF complex DNA-binding subunit SWI4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. de Bruin R, McDonald W, Kalashnikova T, Yates J, Wittenberg C. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell. 2004;117:887-98 pubmed
    ..Like mammalian Rb, Whi5 is a G1-specific transcriptional repressor antagonized by CDK. ..
  2. Wijnen H, Landman A, Futcher B. The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6. Mol Cell Biol. 2002;22:4402-18 pubmed
    ..Cln3-Cdc28 may activate SBF and MBF indirectly, perhaps by phosphorylating some intermediary protein. ..
  3. Gray J, Ogas J, Kamada Y, Stone M, Levin D, Herskowitz I. A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO J. 1997;16:4924-37 pubmed
    ..g. induced by heat shock. The activity of the Pkc1 pathway is partially dependent on Cdc28 activity. Swi4 activates transcription of many genes at the G1-S transition, including CLN1 and CLN2...
  4. Igual J, Johnson A, Johnston L. Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J. 1996;15:5001-13 pubmed
    ..We suggest that SBF and the PKC1 MAP kinase pathway act in concert to maintain cell integrity during bud formation. ..
  5. Costanzo M, Nishikawa J, Tang X, Millman J, Schub O, Breitkreuz K, et al. CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell. 2004;117:899-913 pubmed
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes. ..
  6. de Bruin R, Kalashnikova T, Wittenberg C. Stb1 collaborates with other regulators to modulate the G1-specific transcriptional circuit. Mol Cell Biol. 2008;28:6919-28 pubmed publisher
    ..The repression during G(1) also depends upon Sin3. We speculate that the interaction between Stb1 and Sin3 regulates the Sin3/HDAC complex at G(1)-specific promoters. ..
  7. Wijnen H, Futcher B. Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae. Genetics. 1999;153:1131-43 pubmed
    ..Genetic analysis of the cln3 bck2 defect showed that CLN1, CLN2, and other SBF/MBF target genes have an essential role in addition to the degradation of Sic1. ..
  8. Baetz K, Moffat J, Haynes J, Chang M, Andrews B. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Mol Cell Biol. 2001;21:6515-28 pubmed
    In Saccharomyces cerevisiae, the heterodimeric transcription factor SBF (for SCB binding factor) is composed of Swi4 and Swi6 and activates gene expression at the G(1)/S-phase transition of the mitotic cell cycle...
  9. Ashe M, de Bruin R, Kalashnikova T, McDonald W, Yates J, Wittenberg C. The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae. J Biol Chem. 2008;283:6040-9 pubmed
    ..Similar effects on MBF-regulated transcription are observed. Based upon these results, we conclude that Msa1 acts to advance the timing of G(1)-specific transcription and cell cycle initiation. ..

More Information


  1. Nasmyth K, Dirick L. The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell. 1991;66:995-1013 pubmed
    ..b>SWI4 and SWI6 are transcription factors required for the START-dependent activation of the HO endonuclease gene...
  2. Amon A, Tyers M, Futcher B, Nasmyth K. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell. 1993;74:993-1007 pubmed
    ..This negative regulation of CLNs may occur via the transcription factor SWI4, because CLBs are necessary for G2 repression of SCB-regulated genes like CLN1 and CLN2 but not for repression of ..
  3. Siegmund R, Nasmyth K. The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6. Mol Cell Biol. 1996;16:2647-55 pubmed
    ..These events require activation of Cdc28 kinase by G1 cyclins. Swi4 associates with Swi6 to form the SCB-binding factor complex which activates G1 cyclin genes CLN1 and CLN2 in late ..
  4. Bean J, Siggia E, Cross F. High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae. Genetics. 2005;171:49-61 pubmed
    ..Induction of these genes has been predominantly attributed to two transcription factors, Swi4-Swi6 (SBF) and Mbp1-Swi6 (MBF). Swi4 and Mbp1 are related DNA-binding proteins with dissimilar target sequences...
  5. Madden K, Sheu Y, Baetz K, Andrews B, Snyder M. SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science. 1997;275:1781-4 pubmed
    ..These studies provide evidence for a direct role of the PKC1 pathway in the regulation of the yeast cell cycle and cell growth and indicate that conserved signaling pathways can act to control key regulators of cell division. ..
  6. Manukyan A, Zhang J, Thippeswamy U, Yang J, Zavala N, Mudannayake M, et al. Ccr4 alters cell size in yeast by modulating the timing of CLN1 and CLN2 expression. Genetics. 2008;179:345-57 pubmed publisher
    ..Overexpression of CLN1, CLN2, CLN3, and SWI4 reduces the size of ccr4 delta cells, suggesting that ccr4 delta cells have a G(1)-phase cyclin deficiency...
  7. van der Felden J, Weisser S, Bruckner S, Lenz P, Mösch H. The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. Mol Cell Biol. 2014;34:2283-93 pubmed publisher
    ..and Msa2 (Msa1/2), which were previously found to associate with the cell cycle transcription factor complexes SBF (Swi4/Swi6 cell cycle box binding factor) and MBF (Mbp1/Swi6 cell cycle box binding factor) to control G1-specific ..
  8. Queralt E, Igual J. Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol Cell Biol. 2003;23:3126-40 pubmed
    ..What is more important, we have demonstrated that export of Swi6p to the cytoplasm is required for SBF activity, providing evidence for a functional switch of Swi6p linked to its nucleocytoplasmic shuttling during the cell cycle. ..
  9. Igual J, Toone W, Johnston L. A genetic screen reveals a role for the late G1-specific transcription factor Swi4p in diverse cellular functions including cytokinesis. J Cell Sci. 1997;110 ( Pt 14):1647-54 pubmed
    ..To further understand Swi4p function, we set up a synthetic lethal screen for genes interacting with SWI4. Fourteen conditional mutations which resulted in lethality only in the absence of SWI4 have been isolated...
  10. Piccirillo S, Neog D, Spade D, Van Horn J, Tiede Lewis L, Dallas S, et al. Shrinking Daughters: Rlm1-Dependent G1/S Checkpoint Maintains Saccharomyces cerevisiae Daughter Cell Size and Viability. Genetics. 2017;206:1923-1938 pubmed publisher
    ..phenotype is suppressed by deletion of either SLT2, which encodes the kinase that activates Rlm1, or SWI4, which is also activated by Slt2; suggesting that Slt2 can have opposing roles in regulating the START ..
  11. Betz J, Chang M, Washburn T, Porter S, Mueller C, Jaehning J. Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism. Mol Genet Genomics. 2002;268:272-85 pubmed
    ..We tested the hypothesis that Paf1 communicates with some promoters through the DNA-binding factors Swi4, Mbp1 or Rlm1...
  12. Andrews B, Herskowitz I. Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene. Cell. 1989;57:21-9 pubmed
    ..We show that the SWI4 and SWI6 genes are required for formation of the CCBF-promoter complex in vitro, either as components of CCBF or as ..
  13. Krause S, Gray J. The functional relationships underlying a synthetic genetic network. Commun Integr Biol. 2009;2:4-6 pubmed
    ..Synthetic lethal genetic networks thus appear to be very heterogeneous in nature with important implications for what functional relationships can be discovered from them. ..
  14. Pathak R, Bogomolnaya L, Guo J, Polymenis M. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:1627-38 pubmed
    ..Finally, we report genetic interactions involving GID8, DCR2, and CLN3 (which encodes a G(1) cyclin) or SWI4 (which encodes a transcription factor of the G(1)/S transcription program)...
  15. Lycan D, Mikesell G, Bunger M, Breeden L. Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:7455-65 pubmed
    b>Swi4 and Swi6 form a complex which is required for Start-dependent activation of HO and for high-level expression of G1 cyclin genes CLN1 and CLN2...
  16. Artiles K, Anastasia S, McCusker D, Kellogg D. The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size. PLoS Genet. 2009;5:e1000727 pubmed publisher
    ..Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates. ..
  17. Kaeberlein M, Guarente L. Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics. 2002;160:83-95 pubmed
    ..This work also provides evidence that post-transcriptional regulation is likely to be important both for maintaining cell integrity and for promoting longevity. ..
  18. Córcoles Sáez I, Ballester Tomás L, de la Torre Ruiz M, Prieto J, Randez Gil F. Low temperature highlights the functional role of the cell wall integrity pathway in the regulation of growth in Saccharomyces cerevisiae. Biochem J. 2012;446:477-88 pubmed publisher
    ..Interestingly, swi4? mutant cells display cold sensitivity, but the phenotype is neither mediated by the Slt2p-regulated induction of ..
  19. Andrews B, Moore L. Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Proc Natl Acad Sci U S A. 1992;89:11852-6 pubmed
    In budding yeast, two transcription factors, Swi4 and Swi6, control the expression of important cell cycle regulatory proteins (the G1 cyclins, Cln1 and Cln2, and the cyclin-like Hcs26) as well as the HO gene, whose product initiates ..
  20. Amigoni L, Colombo S, Belotti F, Alberghina L, Martegani E. The transcription factor Swi4 is target for PKA regulation of cell size at the G1 to S transition in Saccharomyces cerevisiae. Cell Cycle. 2015;14:2429-38 pubmed publisher
    ..Transcription of CLN1 is controlled by SBF and MBF dual-regulated promoter. We found that also the deletion of SWI4 gene abolished the transient G1 arrest suggesting that Swi4 is a target responsible for PKA modulation of G1/S ..
  21. Breeden L, Nasmyth K. Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell. 1987;48:389-97 pubmed
    ..These genes fit into three distinct classes with respect to their targets within the HO promoter. SWI4 and SWI6 are specifically required for CACGA4-mediated activation of transcription...
  22. Kim K, Levin D. Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF. Yeast. 2010;27:541-8 pubmed publisher
    ..in response to cell wall stress through a non-catalytic mechanism that involves stable association of Mpk1 with the Swi4 transcription factor. This dimeric complex binds to a Swi4 recognition site in the FKS2 promoter...
  23. Yarrington R, Rudd J, Stillman D. Spatiotemporal cascade of transcription factor binding required for promoter activation. Mol Cell Biol. 2015;35:688-98 pubmed publisher
    ..The yeast HO gene contains nine highly conserved binding sites for the SCB (Swi4/6-dependent cell cycle box) binding factor (SBF) complex (composed of Swi4 and Swi6) in the 700-bp upstream ..
  24. Laman H, Balderes D, Shore D. Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:3608-17 pubmed
    ..Mutations in different cyclin genes (CLN3, CLB5, and CLB2) and two cell cycle transcriptional regulators (SWI4 and MBP1) also suppress the silencing defect at HMR...
  25. Libuda D, Winston F. Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Genetics. 2010;184:985-97 pubmed publisher
    ..Taken together, our results suggest that either reduced histone levels or slowed replication forks stimulate the HTA2-HTB2 amplification event, contributing to the restoration of normal chromatin structure. ..
  26. Toone W, Johnson A, Banks G, Toyn J, Stuart D, Wittenberg C, et al. Rme1, a negative regulator of meiosis, is also a positive activator of G1 cyclin gene expression. EMBO J. 1995;14:5824-32 pubmed
    Control of G1 cyclin expression in Saccharomyces cerevisiae is mediated primarily by the transcription factor SBF (Swi4/Swi6)...
  27. Eriksson P, Ganguli D, Clark D. Spt10 and Swi4 control the timing of histone H2A/H2B gene activation in budding yeast. Mol Cell Biol. 2011;31:557-72 pubmed publisher
    ..UAS3 and UAS4 also contain binding sites for the cell cycle regulator SBF (an Swi4-Swi6 heterodimer), which overlap the Spt10 binding sites...
  28. Ear P, Michnick S. A general life-death selection strategy for dissecting protein functions. Nat Methods. 2009;6:813-6 pubmed publisher
    ..We applied this method to mutational or chemical disruption of protein-protein interactions in yeast and to dissection of the functions of an allosterically activated transcription factor, Swi6. ..
  29. Davidson M, Katou Y, Keszthelyi A, Sing T, Xia T, Ou J, et al. Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J. 2012;31:895-907 pubmed publisher
    ..Together, our data point to a vicious circle in which mutations in gatekeeper genes give rise to genomic instability during S phase, inducing expansion of the dNTP pool, which in turn results in high levels of spontaneous mutagenesis. ..
  30. Porter S, Washburn T, Chang M, Jaehning J. The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genes. Eukaryot Cell. 2002;1:830-42 pubmed
    ..We also examined the possibility that the Paf1 complex acts in the same pathway as either SBF (Swi4/Swi6) or MBF (Mbp1/Swi6), the partially redundant cell cycle transcription factors...
  31. Travesa A, Kalashnikova T, de Bruin R, Cass S, Chahwan C, Lee D, et al. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Mol Cell Biol. 2013;33:1476-86 pubmed publisher
    ..MBF and SBF consist of a common component, Swi6, and a DNA-specific binding protein, Mbp1 and Swi4, respectively. Transcriptional repressors bind to and regulate the activity of both transcription factors...
  32. Harris M, LEE D, Farmer S, Lowndes N, de Bruin R. Binding specificity of the G1/S transcriptional regulators in budding yeast. PLoS ONE. 2013;8:e61059 pubmed publisher
    ..regulation in the budding yeast Saccharomyces cerevisiae depends on three main transcriptional components, Swi4, Swi6 and Mbp1...
  33. Baetz K, Andrews B. Regulation of cell cycle transcription factor Swi4 through auto-inhibition of DNA binding. Mol Cell Biol. 1999;19:6729-41 pubmed
    ..b>Swi4 and Mbp1 are the DNA binding components of SBF and MBF, respectively...
  34. Queralt E, Igual J. Functional connection between the Clb5 cyclin, the protein kinase C pathway and the Swi4 transcription factor in Saccharomyces cerevisiae. Genetics. 2005;171:1485-98 pubmed
    The rsf12 mutation was isolated in a synthetic lethal screen for genes functionally interacting with Swi4. RSF12 is CLB5. The clb5 swi4 mutant cells arrest at G(2)/M due to the activation of the DNA-damage checkpoint...
  35. Gong J, Siede W. SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2009;379:1009-14 pubmed publisher
    ..We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse mutation assays...
  36. Quilis I, Igual J. Molecular basis of the functional distinction between Cln1 and Cln2 cyclins. Cell Cycle. 2012;11:3117-31 pubmed publisher
    ..In short, a region from Cln2 controlling an Msn5-dependent nuclear export mechanism confers a specific functionality to Cln2 compared with Cln1. ..
  37. MacGurn J, Hsu P, Smolka M, Emr S. TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell. 2011;147:1104-17 pubmed publisher
    ..We show that Npr1 inhibits the activity of Art1, an arrestin-like adaptor protein that promotes endocytosis by targeting the Rsp5 ubiquitin ligase to specific PM ..
  38. Tabtiang R, Herskowitz I. Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4707-18 pubmed
    ..These results suggest that Nut1p, Nut2p, Sin4p, and Ccr4p define a group of proteins that negatively regulate transcription in a subtle manner which is revealed by artificial reporter genes. ..
  39. Truman A, Kim K, Levin D. Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation. Mol Cell Biol. 2009;29:6449-61 pubmed publisher
    ..kinase (MAPK) of the cell wall integrity signaling pathway uses a noncatalytic mechanism to activate the SBF (Swi4/Swi6) transcription factor...
  40. Sedgwick S, Taylor I, Adam A, Spanos A, Howell S, Morgan B, et al. Structural and functional architecture of the yeast cell-cycle transcription factor swi6. J Mol Biol. 1998;281:763-75 pubmed
    ..portion of Swi6 which contains a second transcriptional activator and sequences required for heteromerisation with Swi4 or Mbp1...
  41. Cui Z, Horecka J, Jigami Y. Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae. Yeast. 2002;19:69-77 pubmed
    ..Transcription of OCH1 is regulated by two transcription factors, Swi4 and Skn7...
  42. Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
    ..The screening yielded several genes known to perform key roles in cell cycle events, such as CLN3, BCK2 or SWI4, thus proving its usefulness as a tool for this type of studies...
  43. Yimit A, Riffle M, Brown G. Genetic Regulation of Dna2 Localization During the DNA Damage Response. G3 (Bethesda). 2015;5:1937-44 pubmed publisher
    ..We identified 37 gene deletions that affect Dna2-GFP focus formation, 12 with fewer foci and 25 with increased foci. Together these data comprise a useful resource for understanding Dna2 regulation in response to DNA damage. ..
  44. Breeden L, Mikesell G. Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. Genes Dev. 1991;5:1183-90 pubmed
    ..The HO promoter contains 10 copies of a cell cycle-regulated upstream activation sequence, which is activated by SWI4 and SWI6...
  45. Ogas J, Andrews B, Herskowitz I. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell. 1991;66:1015-26 pubmed
    b>SWI4 of budding yeast codes for a component of a transcription factor (cell cycle box factor, or CCBF) necessary for G1-specific expression of HO...
  46. Breeden L, Mikesell G. Three independent forms of regulation affect expression of HO, CLN1 and CLN2 during the cell cycle of Saccharomyces cerevisiae. Genetics. 1994;138:1015-24 pubmed
    ..When SWI4 is constitutively expressed or deleted, cell cycle regulation of CLN1/2 is reduced but not eliminated...
  47. Sidorova J, Breeden L. Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1993;13:1069-77 pubmed
    b>SWI4 and SWI6 play a crucial role in START-specific transcription in Saccharomyces cerevisiae...
  48. Manderson E, Malleshaiah M, Michnick S. A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF. PLoS ONE. 2008;3:e1500 pubmed publisher
    ..We created a fluorescent protein-fragment complementation assay (PCA) to detect the interaction between Cdc28 and Swi4, which leads to the inactivation of SBF...
  49. Guiney E, Klecker T, Emr S. Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex. Mol Biol Cell. 2016;27:4043-4054 pubmed
    ..We present the molecular features in the methionine permease Mup1 that are required for Art1-Rsp5-mediated ubiquitination and endocytosis...
  50. Tran H, Steger D, Iyer V, Johnson A. The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J. 2000;19:2323-31 pubmed
    ..Taken together, these results suggest that Chd1p functions as a nucleosome remodeling factor, and that Chd1p may share overlapping roles with the SWI-SNF complex to regulate transcription. ..
  51. Stillman D, Dorland S, Yu Y. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics. 1994;136:781-8 pubmed
    ..Finally, we show that complete suppression of the swi5 defect in HO expression by sin5 requires the wild-type ACE2 gene. This suggests that one function of SIN5 is to prevent ACE2, a SWI5 homolog, from activating HO expression. ..
  52. Khalfan W, Ivanovska I, Rose M. Functional interaction between the PKC1 pathway and CDC31 network of SPB duplication genes. Genetics. 2000;155:1543-59 pubmed
    ..In support of the model that the PKC1 pathway regulates SPB duplication, one of the phosphorylated forms of Spc110p was absent in pkc1 and mpk1Delta mutants. ..
  53. Beilharz T, Harrison P, Miles D, See M, Le U, Kalanon M, et al. Coordination of Cell Cycle Progression and Mitotic Spindle Assembly Involves Histone H3 Lysine 4 Methylation by Set1/COMPASS. Genetics. 2017;205:185-199 pubmed publisher
    ..Disruption of G1/S regulation in ?mbp1 and ?swi4 transcription factor mutants duplicated both benomyl resistance and suppression of ipl1-2 as was observed with ?..
  54. Queralt E, Igual J. Functional distinction between Cln1p and Cln2p cyclins in the control of the Saccharomyces cerevisiae mitotic cycle. Genetics. 2004;168:129-40 pubmed
    ..In addition, we found that Cln1p showed a more prominent nuclear staining than Cln2p. Finally, chimeric proteins composed of Cln1p and Cln2p revealed that Cln2p integrity is required for its functional specificity. ..
  55. LaFayette S, Collins C, Zaas A, Schell W, Betancourt Quiroz M, Gunatilaka A, et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog. 2010;6:e1001069 pubmed publisher
  56. Li X, Cai M. Recovery of the yeast cell cycle from heat shock-induced G(1) arrest involves a positive regulation of G(1) cyclin expression by the S phase cyclin Clb5. J Biol Chem. 1999;274:24220-31 pubmed
    ..Additional evidence is presented to support a role for Clb5 in maintaining the synchrony between budding and DNA synthesis during normal cell division as well. ..
  57. Li X, Du Y, Siegel S, Ferro Novick S, Novick P. Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2010;21:1772-82 pubmed publisher
    ..The PI4P5-kinase, Mss4p, is an upstream activator of this pool of Slt2p. Ptc1p-dependant inactivation of Slt2p is also needed for mitochondrial inheritance; however, in this case, the relevant pool of Slt2p is not at the bud tip. ..
  58. Coïc E, Sun K, Wu C, Haber J. Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1. Mol Cell Biol. 2006;26:5470-80 pubmed
    ..We now report that donor preference also depends on binding of the Swi4/Swi6 (SBF) transcription factors to an evolutionarily conserved SCB site within RE...
  59. Schulze J, Jackson J, Nakanishi S, Gardner J, Hentrich T, Haug J, et al. Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell. 2009;35:626-41 pubmed publisher
  60. Ewaskow S, Sidorova J, Hendle J, Emery J, Lycan D, Zhang K, et al. Mutation and modeling analysis of the Saccharomyces cerevisiae Swi6 ankyrin repeats. Biochemistry. 1998;37:4437-50 pubmed
    The Swi4-Swi6 family of transcription factors confers G1/S specific transcription in budding and fission yeast...
  61. Imamura Y, Yukawa M, Ueno M, Kimura K, Tsuchiya E. 3,6-Epidioxy-1,10-bisaboladiene inhibits G1 -specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast. FEBS J. 2014;281:4612-21 pubmed publisher
    ..b>Swi4 physically interacts with Swi6 by anti tag coimmunoprecipitation (View interaction).
  62. Catala M, Aksouh L, Abou Elela S. RNA-dependent regulation of the cell wall stress response. Nucleic Acids Res. 2012;40:7507-17 pubmed publisher
    ..The data supports a model for gene regulation in which nuclear mRNA degradation optimizes the cell response to stress and links it to the cell cycle. ..
  63. Sidorova J, Breeden L. Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability. Genetics. 2002;160:123-36 pubmed
    ..We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t)...
  64. Batenchuk C, Tepliakova L, Kaern M. Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis. BMC Genomics. 2010;11:493 pubmed publisher
    ..While the method was developed for growth phenotype, it should apply equally well for other phenotypes, including the expression of fluorescent reporters. ..
  65. Mai B, Breeden L. Identification of target genes of a yeast transcriptional repressor. Methods Mol Biol. 2006;317:267-77 pubmed
    ..repressor with homology to the DNA binding domains of two cell-cycle regulatory transcription factors, Swi4 and Mbp1. Target genes bound and regulated by Xbp1, have been identified using differential display (DD)...
  66. Shaner L, Gibney P, Morano K. The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis. Curr Genet. 2008;54:1-11 pubmed publisher
    ..In addition to Rlm1, Slt2 activates the Swi4/Swi6 heterodimer SBF in response to cell wall damage...
  67. Alepuz P, Matheos D, Cunningham K, Estruch F. The Saccharomyces cerevisiae RanGTP-binding protein msn5p is involved in different signal transduction pathways. Genetics. 1999;153:1219-31 pubmed
    ..Therefore, Msn5p could be a receptor for several proteins involved in different signaling pathways. ..
  68. Hess D, Winston F. Evidence that Spt10 and Spt21 of Saccharomyces cerevisiae play distinct roles in vivo and functionally interact with MCB-binding factor, SCB-binding factor and Snf1. Genetics. 2005;170:87-94 pubmed
    ..genes suggested that they may interact with two factors previously shown to be present at histone loci, SBF (Swi4 and Swi6) and MBF (Mbp1 and Swi6)...
  69. Koch C, Moll T, Neuberg M, Ahorn H, Nasmyth K. A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science. 1993;261:1551-7 pubmed
    ..A transcription factor, called SBF, is composed of Swi4 and Swi6 proteins and activates transcription of G1 cyclin genes...