SWE1

Summary

Gene Symbol: SWE1
Description: tyrosine protein kinase SWE1
Alias: WEE1, tyrosine protein kinase SWE1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sreenivasan A, Kellogg D. The elm1 kinase functions in a mitotic signaling network in budding yeast. Mol Cell Biol. 1999;19:7983-94 pubmed
    ..Previous studies have suggested that Elm1 may function to negatively regulate the Swe1 kinase...
  2. Ross K, COHEN FIX O. The role of Cdh1p in maintaining genomic stability in budding yeast. Genetics. 2003;165:489-503 pubmed
    ..We propose that the failure to degrade cyclins at the end of mitosis leaves cdh1delta mutant strains with abnormal Cdc28p/Clb activity that interferes with proper chromosome segregation. ..
  3. Shulewitz M, Inouye C, Thorner J. Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:7123-37 pubmed
    ..These complexes are held in an inactive state via phosphorylation of Tyr19 in the ATP-binding loop of Cdc28 by the Swe1 protein kinase. The HSL1 and HSL7 gene products act as negative regulators of Swe1...
  4. Donnianni R, Ferrari M, Lazzaro F, Clerici M, Tamilselvan Nachimuthu B, Plevani P, et al. Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. PLoS Genet. 2010;6:e1000763 pubmed publisher
    ..We propose that Cdc5 interferes with the checkpoint response to DSBs acting at multiple levels in the signal transduction pathway and at an early step required to resect DSB ends. ..
  5. Park C, Song S, Lee P, Shou W, Deshaies R, Lee K. Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis. Genetics. 2003;163:21-33 pubmed
    ..Loss of SWE1, which phosphorylates and inactivates the budding yeast Cdk1 homolog Cdc28p, suppressed the cdc5-3 hsl1Delta defect,..
  6. Cid V, Shulewitz M, McDonald K, Thorner J. Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle. Mol Biol Cell. 2001;12:1645-69 pubmed
    ..Clb-bound Cdc28 is susceptible to inhibitory tyrosine phosphorylation by Swe1 protein kinase...
  7. Kaiser P, Sia R, Bardes E, Lew D, Reed S. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Genes Dev. 1998;12:2587-97 pubmed
    ..We demonstrate the involvement of Met30 in the degradation of the Cdk-inhibitory kinase Swe1. Swe1 is stabilized in met30 mutants and GST-Met30 pull-down experiments reveal that Met30 specifically binds Swe1 ..
  8. Hu F, Aparicio O. Swe1 regulation and transcriptional control restrict the activity of mitotic cyclins toward replication proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005;102:8910-5 pubmed
    ..shows that the combination of early cell cycle expression and deletion of the CDK inhibitor Saccharomyces Wee1 (Swe1) enables the mitotic B-type (Clb) cyclins Clb2, Clb3, and Clb4 of Saccharomyces cerevisiae to initiate S phase with ..
  9. Liang F, Jin F, Liu H, Wang Y. The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase. Mol Biol Cell. 2009;20:3671-9 pubmed publisher
    ..Here, we show evidence indicating that Cdc5 promotes Cdc14 release primarily by stimulating the degradation of Swe1, the inhibitory kinase for mitotic Cdk...

More Information

Publications71

  1. Traven A, Beilharz T, Lo T, Lueder F, Preiss T, Heierhorst J. The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiae. Genetics. 2009;182:955-66 pubmed publisher
    ..g., ectopic bud-localized septin rings), particularly upon activation of the Cdc28-inhibitory kinase Swe1. Aberrant septin staining was also observed in the deadenylase-dead ccr4-1 mutant, demonstrating the deadenylase ..
  2. Anastasia S, Nguyen D, Thai V, Meloy M, Macdonough T, Kellogg D. A link between mitotic entry and membrane growth suggests a novel model for cell size control. J Cell Biol. 2012;197:89-104 pubmed publisher
    ..In this paper, we report that blocking membrane traffic causes a mitotic checkpoint arrest via Wee1-dependent inhibitory phosphorylation of Cdk1...
  3. Simpson Lavy K, Brandeis M. Clb2 and the APC/C(Cdh1) regulate Swe1 stability. Cell Cycle. 2010;9:3046-53 pubmed publisher
    b>Swe1/Wee1 regulates mitotic entry by inhibiting Clb2-Cdk1 and its accumulation is involved in stress induced G(2) arrest. The APC/C(Cdh1) substrates Cdc5, Clb2 and Hsl1 regulate Swe1 degradation...
  4. Liu H, Wang Y. The function and regulation of budding yeast Swe1 in response to interrupted DNA synthesis. Mol Biol Cell. 2006;17:2746-56 pubmed
    ..Using budding yeast as a model system, we found that Swe1, a negative regulator of Cdk, appears at S-phase and accumulates in HU treatment cells...
  5. Keaton M, Szkotnicki L, Marquitz A, Harrison J, Zyla T, Lew D. Nucleocytoplasmic trafficking of G2/M regulators in yeast. Mol Biol Cell. 2008;19:4006-18 pubmed publisher
    ..Here, we identify localization motifs in the budding yeast Swe1p (Wee1) and Mih1p (Cdc25) cell cycle regulators...
  6. McNulty J, Lew D. Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae. Curr Biol. 2005;15:2190-8 pubmed
    ..Swe1p does not respond to insufficient bud size. Instead, actin stress empowers Swe1p to promote arrest. The effectiveness of Swe1p in promoting that arrest declines as cells progress through the cell cycle. ..
  7. Artiles K, Anastasia S, McCusker D, Kellogg D. The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size. PLoS Genet. 2009;5:e1000727 pubmed publisher
    ..Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates. ..
  8. Sakchaisri K, Asano S, Yu L, Shulewitz M, Park C, Park J, et al. Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A. 2004;101:4124-9 pubmed
    ..Timely mitotic entry in budding yeast requires inactivation of Swe1 (Wee1 ortholog)...
  9. Hu F, Gan Y, Aparicio O. Identification of Clb2 residues required for Swe1 regulation of Clb2-Cdc28 in Saccharomyces cerevisiae. Genetics. 2008;179:863-74 pubmed publisher
    ..Saccharomyces Wee1 (Swe1) inhibits Cdc28 (Cdk1) associated with the mitotic cyclin, Clb2, but not with the G(1) (Cln1, -2, and -3) or the S-..
  10. Ahn S, Tobe B, Fitz Gerald J, Anderson S, Acurio A, Kron S. Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p. Mol Biol Cell. 2001;12:3589-600 pubmed
    ..that alters a residue involved in Swe1p inhibition of Cdc28p, was unique in being suppressed by deficiency of SWE1 or CLN1...
  11. McMillan J, Theesfeld C, Harrison J, Bardes E, Lew D. Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:3560-75 pubmed
    ..Third, a screen for functional but nondegradable mutants of SWE1 identified two small regions of Swe1p that are key to its degradation...
  12. Raspelli E, Cassani C, Lucchini G, Fraschini R. Budding yeast Dma1 and Dma2 participate in regulation of Swe1 levels and localization. Mol Biol Cell. 2011;22:2185-97 pubmed publisher
    Timely down-regulation of the evolutionarily conserved protein kinase Swe1 plays an important role in cell cycle control, as Swe1 can block nuclear division through inhibitory phosphorylation of the catalytic subunit of cyclin-dependent ..
  13. Bartholomew C, Woo S, Chung Y, Jones C, Hardy C. Cdc5 interacts with the Wee1 kinase in budding yeast. Mol Cell Biol. 2001;21:4949-59 pubmed
    ..Others have shown that Swe1 is required for coupling mitosis to bud formation during a perturbed cell cycle...
  14. Bouquin N, Barral Y, Courbeyrette R, Blondel M, Snyder M, Mann C. Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. J Cell Sci. 2000;113 ( Pt 8):1435-45 pubmed
    ..In addition, the elm1delta;) morphological defects can be suppressed by deletion of the SWE1 gene, but not the cytokinesis defect nor the septin mislocalisation...
  15. Asano S, Park J, Sakchaisri K, Yu L, Song S, Supavilai P, et al. Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 2005;24:2194-204 pubmed
    In eukaryotes, entry into mitosis is induced by cyclin B-bound Cdk1, which is held in check by the protein kinase, Wee1. In budding yeast, Swe1 (Wee1 ortholog) is targeted to the bud neck through Hsl1 (Nim1-related kinase) and its adaptor ..
  16. Yang H, Jiang W, Gentry M, Hallberg R. Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation. Mol Cell Biol. 2000;20:8143-56 pubmed
    ..By contrast, while Swe1p levels are similar in unsynchronized and S-phase-arrested wild-type and cdc55-null cells, Swe1 kinase is found at elevated levels in mitosis-arrested cdc55-null cells...
  17. Suzuki M, Igarashi R, Sekiya M, Utsugi T, Morishita S, Yukawa M, et al. Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae. Nat Cell Biol. 2004;6:861-71 pubmed
    ..Components of the dynactin complex are required to achieve the G2 arrest whilst keeping cells highly viable. Thus, the dynactin complex has a function in a checkpoint that monitors cell wall synthesis. ..
  18. Enserink J, Smolka M, Zhou H, Kolodner R. Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae. J Cell Biol. 2006;175:729-41 pubmed
    ..with septin ring pathway components, and, along with other checkpoint proteins, controls the timely degradation of Swe1 during replication stress, thereby facilitating proper bud growth...
  19. King K, Jin M, Lew D. Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering. Eukaryot Cell. 2012;11:1496-502 pubmed publisher
    ..However, both Hsl1p and Hsl7p are still required for Swe1p degradation, implying that these proteins play additional roles beyond localizing Swe1p to the neck. ..
  20. Longtine M, Theesfeld C, McMillan J, Weaver E, Pringle J, Lew D. Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:4049-61 pubmed
    ..e., after a bud has formed). ..
  21. Lim H, Goh P, Surana U. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol Cell Biol. 1996;16:6385-97 pubmed
    ..We also find that the overexpression of SWE1, the budding-yeast homolog of wee1, also leads to a failure to segregate SPBs...
  22. Barral Y, Mermall V, Mooseker M, Snyder M. Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast. Mol Cell. 2000;5:841-51 pubmed
    ..We propose that septins maintain cell polarity by specifying a boundary between cortical domains. ..
  23. Rice L, Plakas C, Nickels J. Loss of meiotic rereplication block in Saccharomyces cerevisiae cells defective in Cdc28p regulation. Eukaryot Cell. 2005;4:55-62 pubmed
    ..where Cdc28p activity is improperly regulated--either through the loss of function of the Schizosaccharomyces pombe wee1 ortholog Swe1p or through the expression of a dominant CDC28 allele, CDC28AF--diploid yeast cells are able to ..
  24. Park J, Park C, Sakchaisri K, Karpova T, Asano S, McNally J, et al. Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p. Mol Cell Biol. 2004;24:9873-86 pubmed
    ..Thus, SPB- and the bud-neck-localized Cdc5p control most of the critical Cdc5p functions and downregulation of Bfa1p and Swe1p at the respective locations are two critical factors that require Cdc5p. ..
  25. Harvey S, Charlet A, Haas W, Gygi S, Kellogg D. Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell. 2005;122:407-20 pubmed
    ..We report here that Swe1, the budding-yeast homolog of Wee1, is directly regulated by Cdk1...
  26. McMillan J, Longtine M, Sia R, Theesfeld C, Bardes E, Pringle J, et al. The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol. 1999;19:6929-39 pubmed
    In Saccharomyces cerevisiae, the Wee1 family kinase Swe1p is normally stable during G(1) and S phases but is unstable during G(2) and M phases due to ubiquitination and subsequent degradation...
  27. Leu J, Roeder G. The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28. Mol Cell. 1999;4:805-14 pubmed
    ..In S. cerevisiae, this checkpoint requires Swe1, which phosphorylates and inactivates the cyclin-dependent kinase Cdc28...
  28. Song S, Lee K. A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis. J Cell Biol. 2001;152:451-69 pubmed
    ..Thus, we propose that Cdc5 may coordinate mitotic exit with cytokinesis by participating in both anaphase promoting complex activation and a polo-box-dependent cytokinetic pathway. ..
  29. McMillan J, Sia R, Lew D. A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. J Cell Biol. 1998;142:1487-99 pubmed
    ..However, the ability to respond to such perturbations by delaying cell cycle progression was restricted to a narrow window of the cell cycle, delimited by the periodic accumulation of the checkpoint effector, Swe1p. ..
  30. Clotet J, Escote X, Adrover M, Yaakov G, Garí E, Aldea M, et al. Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity. EMBO J. 2006;25:2338-46 pubmed
    ..site of the Hsl1 checkpoint kinase, which results in delocalization of Hsl7 from the septin ring and leads to Swe1 accumulation...
  31. Booher R, Deshaies R, Kirschner M. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 1993;12:3417-26 pubmed
    b>Wee1 is a protein kinase that negatively regulates p34cdc2 kinase activity. We have identified a Saccharomyces cerevisiae wee1 homolog encoded by the SWE1 gene...
  32. Barral Y, Parra M, Bidlingmaier S, Snyder M. Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev. 1999;13:176-87 pubmed
    ..In Saccharomyces cerevisiae, the Swe1 protein has been shown previously to phosphorylate and inactivate the cyclin-dependent kinase, Cdc28, thereby ..
  33. Mizunuma M, Hirata D, Miyahara K, Tsuchiya E, Miyakawa T. Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Nature. 1998;392:303-6 pubmed
    ..Zds1 (also known as Oss1 and Hst1) is important in repressing the transcription of SWE1 in G2 phase. In the presence of high calcium levels, cells lacking Zds1 are delayed in entering mitosis...
  34. Sia R, Herald H, Lew D. Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell. 1996;7:1657-66 pubmed
    ..We show that the ability of this checkpoint to delay nuclear division requires the SWE1 gene, encoding a protein kinase that inhibits the master cell cycle regulatory kinase Cdc28...
  35. Pal G, Paraz M, Kellogg D. Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1. J Cell Biol. 2008;180:931-45 pubmed publisher
    ..Because casein kinase 1 is associated with sites of polar growth, it may regulate Mih1 as part of a signaling mechanism that links successful completion of growth-related events to cell cycle progression. ..
  36. Harvey S, Enciso G, Dephoure N, Gygi S, Gunawardena J, Kellogg D. A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast. Mol Biol Cell. 2011;22:3595-608 pubmed publisher
    ..Little is known about how stepwise activation of Cdk1 is achieved. A key regulator of Cdk1 is the Wee1 kinase, which phosphorylates and inhibits Cdk1...
  37. Rossio V, Yoshida S. Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol. 2011;193:445-54 pubmed publisher
    ..Our analysis defines the long-sought molecular function for the zillion different screens family proteins and reveals the importance of the regulation of PP2A localization for proper mitotic progression. ..
  38. Soriano Carot M, Bañó M, Igual J. The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress. Cell Div. 2012;7:1 pubmed publisher
    ..However, slt2 mutant cells showed an elongated bud and partially impaired Swe1 degradation after replicative stress, indicating that Slt2 could contribute, in parallel with Rad53, to bud ..
  39. Bokros M, Gravenmier C, Jin F, Richmond D, Wang Y. Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase. Cell Rep. 2016;14:1074-1085 pubmed publisher
    ..This mechanism is required for efficient SAC silencing after SAC is challenged, and untimely Fin1-kinetochore association causes premature SAC silencing and chromosome missegregation. ..
  40. Raspelli E, Cassani C, Chiroli E, Fraschini R. Budding yeast Swe1 is involved in the control of mitotic spindle elongation and is regulated by Cdc14 phosphatase during mitosis. J Biol Chem. 2015;290:1-12 pubmed publisher
    ..This modification is brought about by the protein kinase Swe1 that inhibits Cdk1 activation thus blocking mitotic entry...
  41. Tsuchiya D, Lacefield S. Cdk1 modulation ensures the coordination of cell-cycle events during the switch from meiotic prophase to mitosis. Curr Biol. 2013;23:1505-13 pubmed publisher
    ..The S. cerevisiae Wee1 homolog Swe1 prevents the formation of multinucleate cells by restraining M phase CDK activity to allow bud formation prior to ..
  42. Orlova M, Ozcetin H, Barrett L, Kuchin S. Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae. Eukaryot Cell. 2010;9:208-14 pubmed publisher
    ..Our results suggest that Sak1 is involved in nitrogen signaling upstream of Snf1. ..
  43. Iwase M, Toh e A. Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. Cell Struct Funct. 2004;29:1-15 pubmed
    ..double disruptants exhibited an elongated cell morphology, which was suppressed by the disruption of SWE1, indicating that REI1 is a new member of genes belonging to the mitotic signaling network that negatively regulates ..
  44. Larson J, Kozubowski L, Tatchell K. Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae. J Cell Sci. 2010;123:1050-9 pubmed publisher
    ..Furthermore, we show that Bni4 has a Swe1-dependent role in regulating the cell morphogenesis checkpoint in response to hydroxyurea, which suggests that the ..
  45. Zou W, Yan J, Zhao N, Niu S, Huang X. A novel role for the alcohol sensitive ring/PHD finger protein Asr1p in regulating cell cycle mediated by septin-dependent assembly in yeast. Biochem Biophys Res Commun. 2015;458:208-13 pubmed publisher
    ..Taken together, our current data suggested a close relationship in the assembly between septin and actin cytoskeleton, which also partially explained how actin cytoskeleton participated in the regulation of the checkpoint of G2/M. ..
  46. Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 2006;174:1135-49 pubmed
    ..interactions and silencing phenotypes were suppressed by inactivation of the morphogenesis checkpoint, either by SWE1 deletion or by preventing Cdc28p phosphorylation...
  47. Mahajan K, Fang B, Koomen J, Mahajan N. H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes. Nat Struct Mol Biol. 2012;19:930-7 pubmed publisher
    ..We identified WEE1 as the kinase that phosphorylates H2B at Tyr37...
  48. Traven A, Lo T, Lithgow T, Heierhorst J. The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS ONE. 2010;5:e10651 pubmed publisher
    ..The Pop2-independent roles for Puf5 could involve spatial control of gene expression, a proposition supported by our data indicating that the active form of Puf5 is localised to cytoplasmic foci. ..
  49. Shitamukai A, Hirata D, Sonobe S, Miyakawa T. Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae. J Biol Chem. 2004;279:3651-61 pubmed
  50. Kim J, Rose M. Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling. PLoS Genet. 2015;11:e1005684 pubmed publisher
    ..A swe1 mutation largely abolished signaling, breaking the positive feedback that leads to amplification of sadF signaling...
  51. Campsteijn C, Wijnands Collin A, Logie C. Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet. 2007;3:e92 pubmed
    ..Taken together, our results implicate RSC in regulation of the G1/S-phase transition and establish a hitherto unanticipated role for RSC-mediated chromatin remodeling in ploidy maintenance. ..
  52. Kang M, Yu S, Kim H, Gorospe C, Choi B, Lee S, et al. Yeast RAD2, a homolog of human XPG, plays a key role in the regulation of the cell cycle and actin dynamics. Biol Open. 2014;3:29-41 pubmed publisher
    ..These results provide insights into the role of RAD2 in post-UV irradiation cell cycle regulation and actin assembly, which may be an underlying cause of XPG/CS. ..
  53. García Rodríguez N, Díaz de la Loza M, Andreson B, Monje Casas F, Rothstein R, Wellinger R. Impaired manganese metabolism causes mitotic misregulation. J Biol Chem. 2012;287:18717-29 pubmed publisher
    ..On the other hand, we find that depletion of the Golgi Mn(2+) pool requires a functional morphology checkpoint to avoid the formation of polyploid cells. ..
  54. Mollapour M, Tsutsumi S, Donnelly A, Beebe K, Tokita M, Lee M, et al. Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell. 2010;37:333-43 pubmed publisher
    Saccharomyces WEE1 (Swe1), the only "true" tyrosine kinase in budding yeast, is an Hsp90 client protein...
  55. Matmati N, Kitagaki H, Montefusco D, Mohanty B, Hannun Y. Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M. J Biol Chem. 2009;284:8241-6 pubmed publisher
    ..Significantly, deletion of SWE1 in an isc1Delta background overcame the G(2)/M block in response to HU...
  56. Bandhakavi S, McCann R, Hanna D, Glover C. Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae. FEBS Lett. 2003;554:295-300 pubmed
    ..Activation of the positive feedback loop between CK2 and Cdc37 likely contributes to the pleiotropic nature of ZDS1,2, as both CK2 and Cdc37 regulate diverse cellular functions. ..
  57. McQueen J, van Dyk D, Young B, Loewen C, Measday V. The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division. Cell Cycle. 2012;11:3421-32 pubmed publisher
    ..Deletion of the Cdk1 inhibitory kinase, SWE1, in combination with a mck1? mutant results in a synthetic growth defect, suggesting that Mck1 and Swe1 function in ..
  58. King K, Kang H, Jin M, Lew D. Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. Mol Biol Cell. 2013;24:914-22 pubmed publisher
    ..cell cycle in such circumstances, the morphogenesis checkpoint delays nuclear division via the mitosis-inhibitory Wee1-family kinase, Swe1p...
  59. Saracino F, Bassler J, Muzzini D, Hurt E, Agostoni Carbone M. The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects. Cell Cycle. 2004;3:648-54 pubmed
    ..Interestingly, additional deletion of the non-essential Swe1 kinase, the homolog of S...
  60. Kammerer D, Stevermann L, Liakopoulos D. Ubiquitylation regulates interactions of astral microtubules with the cleavage apparatus. Curr Biol. 2010;20:1233-43 pubmed publisher
    ..Photoconversion experiments showed that Kar9 association with aMTs is stable. We propose that ubiquitylation controls interactions of aMTs with the cleavage apparatus through localized disassembly of Kar9 complexes. ..
  61. Mollapour M, Tsutsumi S, Neckers L. Hsp90 phosphorylation, Wee1 and the cell cycle. Cell Cycle. 2010;9:2310-6 pubmed
    ..Yeast expressing non-phosphorylatable yHsp90-Y24F, like swe1? yeast, undergo premature nuclear division that is insensitive to G2/M checkpoint arrest...
  62. Loewen C, Young B, Tavassoli S, Levine T. Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol. 2007;179:467-83 pubmed
    ..This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint...