Gene Symbol: Swa2p
Description: Swa2p
Alias: AUX1, BUD24, Swa2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Pishvaee B, Costaguta G, Yeung B, Ryazantsev S, Greener T, Greene L, et al. A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo. Nat Cell Biol. 2000;2:958-63 pubmed
    ..Here we report the identification and characterization of a Saccharomyces cerevisiae J-domain protein, Aux1. Inactivation of Aux1 results in accumulation of clathrin-coated vesicles, impaired cargo delivery, and an ..
  2. Gall W, Higginbotham M, Chen C, Ingram M, Cyr D, Graham T. The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast. Curr Biol. 2000;10:1349-58 pubmed
    ..Like auxilin, Swa2p has a clathrin-binding domain and is able to stimulate the ATPase activity of Hsc70...
  3. Gall W, Geething N, Hua Z, Ingram M, Liu K, Chen S, et al. Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Curr Biol. 2002;12:1623-7 pubmed
    ..These data provide the first in vivo evidence for an integral membrane protein requirement in forming CCVs. ..
  4. Oliver E, Troisi E, Hines J. Prion-specific Hsp40 function: The role of the auxilin homolog Swa2. Prion. 2017;11:174-185 pubmed publisher
  5. Rainey M, Korostyshevsky D, Lee S, Perlstein E. The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast. Genetics. 2010;185:1221-33 pubmed publisher
    ..Overall, our study identifies two evolutionarily conserved membrane--active processes-vacuolar acidification and clathrin-coat formation--as modulators of sertraline's action at membranes...
  6. Xiao J, Kim L, Graham T. Dissection of Swa2p/auxilin domain requirements for cochaperoning Hsp70 clathrin-uncoating activity in vivo. Mol Biol Cell. 2006;17:3281-90 pubmed
    ..To test these requirements in vivo, we performed a mutational analysis of Swa2p, the yeast auxilin ortholog...
  7. Matta Camacho E, Kozlov G, Trempe J, Gehring K. Atypical binding of the Swa2p UBA domain to ubiquitin. J Mol Biol. 2009;386:569-77 pubmed publisher
    b>Swa2p is an auxilin-like yeast protein that is involved in vesicular transport and required for uncoating of clathrin-coated vesicles...
  8. Krantz K, Puchalla J, Thapa R, Kobayashi C, Bisher M, Viehweg J, et al. Clathrin coat disassembly by the yeast Hsc70/Ssa1p and auxilin/Swa2p proteins observed by single-particle burst analysis spectroscopy. J Biol Chem. 2013;288:26721-30 pubmed publisher
    ..Yet, despite previous characterization of the yeast Hsc70 ortholog, Ssa1p, and the auxilin-like ortholog, Swa2p, testing mechanistic models for disassembly of nonneuronal clathrin coats has been limited by the absence of a ..
  9. Guo J, Polymenis M. Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep. 2006;7:1124-7 pubmed
    ..Our results are consistent with de-phosphorylation of Ire1 being a mechanism for antagonizing UPR signalling. ..

More Information


  1. Martineau C, Melki R, Kabani M. Swa2p-dependent clathrin dynamics is critical for Flo11p processing and 'Mat' formation in the yeast Saccharomyces cerevisiae. FEBS Lett. 2010;584:1149-55 pubmed publisher
    ..Here, we show that Swa2p, an auxilin ortholog required for clathrin-coated vesicle uncoating, is strictly required for biofilm formation...
  2. Chim N, Gall W, Xiao J, Harris M, Graham T, Krezel A. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae. Proteins. 2004;54:784-93 pubmed
    The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid ..
  3. Shen D, Yuan H, Hutagalung A, Verma A, K├╝mmel D, Wu X, et al. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. J Cell Biol. 2013;202:509-26 pubmed publisher
    ..We propose that the exocyst is recruited to secretory vesicles by the combinatorial signals of Sec4-GTP and the Snc proteins. This could help to confer both specificity and directionality to vesicular traffic. ..
  4. Troisi E, Rockman M, Nguyen P, Oliver E, Hines J. Swa2, the yeast homolog of mammalian auxilin, is specifically required for the propagation of the prion variant [URE3-1]. Mol Microbiol. 2015;97:926-41 pubmed publisher
    ..variant [URE3-1], we screened 12 yeast cytosolic J-proteins, and here we report a novel role for the J-protein Swa2/Aux1. Swa2 is the sole yeast homolog of the mammalian protein auxilin, which, like Swa2, functions in vesicle-mediated ..
  5. Du Y, Walker L, Novick P, Ferro Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006;25:4413-22 pubmed
    ..Our findings indicate that Ptc1p and Nbp2p regulate ER inheritance through the CWI MAPK pathway by modulating the MAPK, Slt2p. ..
  6. Sahi C, Craig E. Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci U S A. 2007;104:7163-8 pubmed
    ..However, a subset of Hsp70 functions requires specific J protein partners, likely demanding either sublocalization within the compartment or binding to specific client proteins. ..
  7. Webster M, McCaffery J, COHEN FIX O. Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation. J Cell Biol. 2010;191:1079-88 pubmed publisher
    ..Moreover, flares may facilitate maintenance of a constant nuclear/cell volume ratio in the face of altered membrane proliferation. ..
  8. Du Y, Pypaert M, Novick P, Ferro Novick S. Aux1p/Swa2p is required for cortical endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2001;12:2614-28 pubmed
    ..This approach has revealed that AUX1/SWA2 plays a role in ER inheritance. The COOH terminus of Aux1p/Swa2p contains a J-domain that is highly related to the J-domain of auxilin, which stimulates the uncoating of clathrin-..