Genomes and Genes
Gene Symbol: SUR2
Description: sphingosine hydroxylase
Alias: SYR2, sphingosine hydroxylase
Species: Saccharomyces cerevisiae S288c
- Haak D, Gable K, Beeler T, Dunn T. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J Biol Chem. 1997;272:29704-10 pubmedThe Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids...
- Kim S, Fyrst H, Saba J. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics. 2000;156:1519-29 pubmed..the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, and SUR2. LCB4 and LCB5 encode kinases that phosphorylate long chain bases...
- Beeler T, Bacikova D, Gable K, Hopkins L, Johnson C, Slife H, et al. The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem. 1998;273:30688-94 pubmed..The recombinant protein catalyzes the NADPH-dependent reduction of 3-ketosphinganine. These data indicate that Tsc10p is necessary and sufficient for catalyzing the NADPH-dependent reduction of 3-ketosphinganine to dihydrosphingosine. ..
- Yamagata M, Obara K, Kihara A. Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation. Genes Cells. 2013;18:650-9 pubmed publisher..We report here that normal synthesis of complex sphingolipids is important for cell survival in nitrogen-starved medium. ..
- Clay L, Caudron F, Denoth Lippuner A, Boettcher B, Buvelot Frei S, Snapp E, et al. A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell. elife. 2014;3:e01883 pubmed..DOI: http://dx.doi.org/10.7554/eLife.01883.001...
- Uemura S, Shishido F, Tani M, Mochizuki T, Abe F, Inokuchi J. Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae. J Lipid Res. 2014;55:1343-56 pubmed publisher..Notably, the fluorescence recovery of Hxt1-EGFP was dramatically decreased in the sur2? mutant (absence of C4-OH) under the csg1?csh1? background, in which mannosylation of IPC is blocked leading to IPC ..
- Grilley M, Stock S, Dickson R, Lester R, Takemoto J. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J Biol Chem. 1998;273:11062-8 pubmedThe Saccharomyces cerevisiae gene SYR2, necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E, is shown to be required for 4-hydroxylation of long chain bases in sphingolipid biosynthesis...
- Cliften P, Wang Y, Mochizuki D, Miyakawa T, Wangspa R, Hughes J, et al. SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology. 1996;142 ( Pt 3):477-84 pubmed..SYR2 was identical to SUR2, which is involved in survival during nutritional starvation...