Gene Symbol: SUR2
Description: sphingosine hydroxylase
Alias: SYR2, sphingosine hydroxylase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Swain E, Baudry K, Stukey J, McDonough V, Germann M, Nickels J. Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. J Biol Chem. 2002;277:26177-84 pubmed
    ..Gene dosage experiments using the sphingolipid long chain sphingoid base (LCB) hydroxylase gene, SUR2, suggest that erg26-1 cells may accumulate LCB, thus placing one point of sterol regulation of sphingolipid ..
  2. Tani M, Toume M. Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase. Microbiology. 2015;161:2369-83 pubmed publisher
    ..or an increase in the hydroxylation level of the ceramide moiety of sphingolipids on overexpression of Scs7 and Sur2 sphingolipid hydroxylases enhanced the growth defect of V-ATPase-deleted cells at pH 7.2...
  3. Toume M, Tani M. Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae. FEMS Microbiol Lett. 2014;358:64-71 pubmed publisher
    ..These results suggested that an increase in sphingolipid biosynthesis caused by a change in the activity of serine palmitoyltransferase causes resistance to syringomycin E. ..
  4. Dunn T, Haak D, Monaghan E, Beeler T. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Yeast. 1998;14:311-21 pubmed
    ..Scs7p is therefore likely to be the enzyme that hydroxylates the C26-fatty acid of IPC-C. ..
  5. Desfarges L, Durrens P, Juguelin H, Cassagne C, Bonneu M, Aigle M. Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast. 1993;9:267-77 pubmed
    ..Ten mutants were obtained, ranged amongst four complementation groups, named SUR1, SUR2, SUR3 and SUR4...
  6. Balguerie A, Bagnat M, Bonneu M, Aigle M, Breton A. Rvs161p and sphingolipids are required for actin repolarization following salt stress. Eukaryot Cell. 2002;1:1021-31 pubmed
    ..the rvs161delta-related salt sensitivity all occurred in genes required for sphingolipid biosynthesis: FEN1, SUR4, SUR2, SUR1, and IPT1...
  7. Tani M, Kuge O. Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2012;417:673-8 pubmed publisher
    ..This diversity is created through the action of enzymes encoded by SUR2, SCS7, and as yet unidentified hydroxylation enzyme(s)...
  8. Brace J, Lester R, Dickson R, Rudin C. SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Genetics. 2007;175:65-76 pubmed
    ..A genetic interaction between SVF1 and SUR2 demonstrates that both factors are required for optimal growth and survival, and phenotypic similarities between ..
  9. Matecic M, Stuart S, Holmes S. SIR2-induced inviability is suppressed by histone H4 overexpression. Genetics. 2002;162:973-6 pubmed
    ..These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism. ..

More Information


  1. Haak D, Gable K, Beeler T, Dunn T. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J Biol Chem. 1997;272:29704-10 pubmed
    The Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids...
  2. Kim S, Fyrst H, Saba J. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics. 2000;156:1519-29 pubmed
    ..the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, and SUR2. LCB4 and LCB5 encode kinases that phosphorylate long chain bases...
  3. Beeler T, Bacikova D, Gable K, Hopkins L, Johnson C, Slife H, et al. The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem. 1998;273:30688-94 pubmed
    ..The recombinant protein catalyzes the NADPH-dependent reduction of 3-ketosphinganine. These data indicate that Tsc10p is necessary and sufficient for catalyzing the NADPH-dependent reduction of 3-ketosphinganine to dihydrosphingosine. ..
  4. Guan X, Souza C, Pichler H, Dewhurst G, Schaad O, Kajiwara K, et al. Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell. 2009;20:2083-95 pubmed publisher
  5. Yamagata M, Obara K, Kihara A. Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation. Genes Cells. 2013;18:650-9 pubmed publisher
    ..We report here that normal synthesis of complex sphingolipids is important for cell survival in nitrogen-starved medium. ..
  6. Clay L, Caudron F, Denoth Lippuner A, Boettcher B, Buvelot Frei S, Snapp E, et al. A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell. elife. 2014;3:e01883 pubmed
  7. Uemura S, Shishido F, Tani M, Mochizuki T, Abe F, Inokuchi J. Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae. J Lipid Res. 2014;55:1343-56 pubmed publisher
    ..Notably, the fluorescence recovery of Hxt1-EGFP was dramatically decreased in the sur2? mutant (absence of C4-OH) under the csg1?csh1? background, in which mannosylation of IPC is blocked leading to IPC ..
  8. Grilley M, Stock S, Dickson R, Lester R, Takemoto J. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J Biol Chem. 1998;273:11062-8 pubmed
    The Saccharomyces cerevisiae gene SYR2, necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E, is shown to be required for 4-hydroxylation of long chain bases in sphingolipid biosynthesis...
  9. Cliften P, Wang Y, Mochizuki D, Miyakawa T, Wangspa R, Hughes J, et al. SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology. 1996;142 ( Pt 3):477-84 pubmed
    ..SYR2 was identical to SUR2, which is involved in survival during nutritional starvation...