Gene Symbol: SUR1
Description: mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
Alias: BCL21, CSG1, LPE15, mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Beeler T, Fu D, Rivera J, Monaghan E, Gable K, Dunn T. SUR1 (CSG1/BCL21), a gene necessary for growth of Saccharomyces cerevisiae in the presence of high Ca2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide. Mol Gen Genet. 1997;255:570-9 pubmed
    Saccharomyces cerevisiae cells require two genes, CSG1/SUR1 and CSG2, for growth in 50 mM Ca2+, but not 50 mM Sr2+...
  2. Uemura S, Kihara A, Inokuchi J, Igarashi Y. Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p. J Biol Chem. 2003;278:45049-55 pubmed
    ..Deletion of the CSG2 gene reduced the Csg1p activity and abolished the Csh1p activity. These results suggested that two distinct inositol phosphorylceramide mannosyltransferase complexes, Csg1p-Csg2p and Csh1p-Csg2p, exist. ..
  3. Vionnet C, Roubaty C, Ejsing C, Knudsen J, Conzelmann A. Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem. 2011;286:6769-79 pubmed publisher
    ..Furthermore, mannosylation of PI? is required for the survival of sphingolipid-deficient strains, which depend on SLC1-1. In contrast to lcb1? SLC1-1, 4? SLC1-1 cells grow at 37 °C but remain thermosensitive at 44 °C. ..
  4. Morimoto Y, Tani M. Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae. Mol Microbiol. 2015;95:706-22 pubmed publisher
    ..involved in the synthesis of mannan-type N-glycans is essential for the growth of cells lacking MIPC synthases (Sur1 and Csh1)...
  5. Wiggins C, Munro S. Activity of the yeast MNN1 alpha-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases. Proc Natl Acad Sci U S A. 1998;95:7945-50 pubmed
  6. Helliwell S, Howald I, Barbet N, Hall M. TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics. 1998;148:99-112 pubmed
    ..Overexpression of MSS4, PKC1, PLC1, RHO2, ROM2, or SUR1 suppressed the growth defect of a class A mutant...
  7. Wiederhold E, Gandhi T, Permentier H, Breitling R, Poolman B, Slotboom D. The yeast vacuolar membrane proteome. Mol Cell Proteomics. 2009;8:380-92 pubmed publisher
    ..Our work provides a wealth of information on vacuolar biology and a solid basis for further characterization of vacuolar functions. ..
  8. Fu D, Beeler T, Dunn T. Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants. Yeast. 1994;10:515-21 pubmed
    ..This gene displays non-allelic complementation of the Ca(2+)-sensitive phenotype conferred by the csg1 mutation...
  9. De Block J, Szopinska A, Guerriat B, Dodzian J, Villers J, Hochstenbach J, et al. Yeast Pmp3p has an important role in plasma membrane organization. J Cell Sci. 2015;128:3646-59 pubmed publisher
    ..These genetic interactions, together with lipid binding assays and epifluorescence microscopy, as well as other biochemical experiments, suggest that Pmp3p could be part of a phosphoinositide-regulated stress sensor. ..

More Information


  1. Yamagata M, Obara K, Kihara A. Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation. Genes Cells. 2013;18:650-9 pubmed publisher
    ..this study, we found that yeast cells lacking genes encoding mannosylinositol phosphorylceramide (MIPC) synthases (csg1? csh1?) underwent rapid cell death upon nitrogen starvation, but not upon carbon starvation or carbon and nitrogen ..
  2. Thevissen K, Cammue B, Lemaire K, Winderickx J, Dickson R, Lester R, et al. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc Natl Acad Sci U S A. 2000;97:9531-6 pubmed
    ..Our data support a model in which membrane patches containing sphingolipids act as binding sites for DmAMP1 or, alternatively, are required to anchor membrane or cell wall-associated proteins, which themselves interact with DmAMP1. ..
  3. Lisman Q, Urli Stam D, Holthuis J. HOR7, a multicopy suppressor of the Ca2+-induced growth defect in sphingolipid mannosyltransferase-deficient yeast. J Biol Chem. 2004;279:36390-6 pubmed
    ..Our findings suggest that induction of Hor7p causes a depolarization of the plasma membrane that may counteract a Ca(2+)-induced influx of toxic cations in IPC-C-overaccumulating cells. ..
  4. Lisman Q, Pomorski T, Vogelzangs C, Urli Stam D, de Cocq van Delwijnen W, Holthuis J. Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids. J Biol Chem. 2004;279:1020-9 pubmed
    ..Mannosylation of IPC is partially dependent on CSG1, a gene encoding a putative sphingolipidmannosyltransferase...
  5. Balguerie A, Bagnat M, Bonneu M, Aigle M, Breton A. Rvs161p and sphingolipids are required for actin repolarization following salt stress. Eukaryot Cell. 2002;1:1021-31 pubmed
    ..salt sensitivity all occurred in genes required for sphingolipid biosynthesis: FEN1, SUR4, SUR2, SUR1, and IPT1...
  6. Dickson R, Lester R. Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 1999;1438:305-21 pubmed
    ..Finally, we discuss recent clues that may help to reveal how sphingolipid synthesis and total cellular sphingolipid content are regulated. ..
  7. Buttner S, Ruli D, Vögtle F, Galluzzi L, Moitzi B, Eisenberg T, et al. A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J. 2011;30:2779-92 pubmed publisher
    ..Thus, the yeast genome encodes a functional BH3 domain that induces cell death through phylogenetically conserved mechanisms. ..
  8. Tani M, Toume M. Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase. Microbiology. 2015;161:2369-83 pubmed publisher
    ..These results indicate the possibility that alteration of the complex sphingolipid composition is an adaptation mechanism for a defect of V-ATPase. ..
  9. Takita Y, Ohya Y, Anraku Y. The CLS2 gene encodes a protein with multiple membrane-spanning domains that is important Ca2+ tolerance in yeast. Mol Gen Genet. 1995;246:269-81 pubmed
    ..We describe here the CLS2 gene and a multicopy suppressor (named BCL21, for bypass of CLS2) of the cls2 mutation...
  10. Tani M, Kuge O. Involvement of complex sphingolipids and phosphatidylserine in endosomal trafficking in yeast Saccharomyces cerevisiae. Mol Microbiol. 2012;86:1262-80 pubmed publisher
    ..These results suggested that specific complex sphingolipids and phosphatidylserine are co-ordinately involved in specific vesicular trafficking pathway. ..
  11. Tani M, Kuge O. Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids. Mol Microbiol. 2010;78:395-413 pubmed
    ..Double mutation analysis involving the SAC1 and non-essential sphingolipid-metabolizing enzyme genes revealed that csg1?, csg2?, ipt1? or scs7? causes synthetic lethality with deletion of SAC1...
  12. Rockwell N, Wolfger H, Kuchler K, Thorner J. ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae. J Membr Biol. 2009;229:27-52 pubmed publisher
    ..Pdr10 therefore acts as a negative regulator for incorporation of Pdr12 into detergent-resistant membranes, a novel role for members of the ABC transporter superfamily...
  13. Uemura S, Kihara A, Iwaki S, Inokuchi J, Igarashi Y. Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2. J Biol Chem. 2007;282:8613-21 pubmed
    ..phosphorylceramide (MIPC), is produced by the redundant inositol phosphorylceramide (IPC) mannosyltransferases Csg1 and Csh1...
  14. Desfarges L, Durrens P, Juguelin H, Cassagne C, Bonneu M, Aigle M. Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast. 1993;9:267-77 pubmed
    ..Ten mutants were obtained, ranged amongst four complementation groups, named SUR1, SUR2, SUR3 and SUR4...
  15. Fu D, Beeler T, Dunn T. Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily. Yeast. 1995;11:283-92 pubmed
    ..This gene displays non-allelic complementation of the Ca(2+)-sensitive phenotype conferred by the csg1 mutation...
  16. Baek S, Kwon E, Bae S, Cho B, Kim S, Hahn J. Improvement of d-Lactic Acid Production in Saccharomyces cerevisiae Under Acidic Conditions by Evolutionary and Rational Metabolic Engineering. Biotechnol J. 2017;12: pubmed publisher
    ..Genome sequencing of JHY5710 reveal that SUR1I245S mutation increases LA tolerance and d-LA-production, whereas a loss-of-function mutation of ERF2 ..
  17. Dunn T, Haak D, Monaghan E, Beeler T. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Yeast. 1998;14:311-21 pubmed
    ..Elimination of the SCS7 gene suppresses the Ca(2+)-sensitive phenotype of csg1 and csg2 mutants...