Gene Symbol: Stp2p
Description: Stp2p
Alias: Stp2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Zargari A, Boban M, Heessen S, Andréasson C, Thyberg J, Ljungdahl P. Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2. J Biol Chem. 2007;282:594-605 pubmed
    ..This study documents additional components of a novel mechanism controlling transcription in eukaryotic cells. ..
  2. Wielemans K, Jean C, Vissers S, Andre B. Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors. J Biol Chem. 2010;285:855-65 pubmed publisher
  3. Boban M, Ljungdahl P. Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae. Genetics. 2007;176:2087-97 pubmed
    ..Conversely, the high levels of processed Stp1 and Stp2 that accumulate in the nucleus of induced cells activate transcription in the absence of Dal81. ..
  4. Paulissen S, Slubowski C, Roesner J, Huang L. Timely Closure of the Prospore Membrane Requires SPS1 and SPO77 in Saccharomyces cerevisiae. Genetics. 2016;203:1203-16 pubmed publisher
    ..Genetic dissection of prospore membrane closure finds SPS1 and SPO77 act in parallel to a previously described pathway of prospore membrane closure that involves AMA1, an activator of the meiotic anaphase promoting complex. ..
  5. Menant A, Barbey R, Thomas D. Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells. EMBO J. 2006;25:4436-47 pubmed
    ..The multiple ubiquitin-dependent mechanisms that function in methionine transport regulation further exemplify the pervasive role of ubiquitin in the adaptation of single-cell organisms to environmental modifications. ..
  6. Tanaka N, Mukai Y. Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes. Biochem Biophys Res Commun. 2015;468:32-8 pubmed publisher
    ..These data indicate that Cyc8p-Tup1p plays a role as a transcriptional coactivator for AAT genes via Stp1/2p activators and that lowering intracellular tryptophan by CYC8 deletion causes slow growth. ..
  7. Nielsen P, van den Hazel B, Didion T, de Boer M, Jørgensen M, Planta R, et al. Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2. Mol Gen Genet. 2001;264:613-22 pubmed
    ..Other genes that control BAP2 encode known (Leu3p, Tup1p) and putative (Stp1p, Stp2p) transcription factors...
  8. de Boer M, Nielsen P, Bebelman J, Heerikhuizen H, Andersen H, Planta R. Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. Nucleic Acids Res. 2000;28:974-81 pubmed
    ..In this paper, we show that Stp2p, a protein with considerable similarity to Stp1p, is also involved in the induction of BAP3 expression...
  9. Cardillo S, Bermudez Moretti M, Correa Garcia S. Uga3 and Uga35/Dal81 transcription factors regulate UGA4 transcription in response to gamma-aminobutyric acid and leucine. Eukaryot Cell. 2010;9:1262-71 pubmed publisher
    ..We also found that the Leu3 transcription factor negatively regulates UGA4 transcription, although this seems to be through an indirect mechanism. ..

More Information


  1. Tumusiime S, Zhang C, Overstreet M, Liu Z. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway. J Biol Chem. 2011;286:4620-31 pubmed publisher
    ..Our results indicate that the functions of two seemingly redundant transcription factors can be separated by differential degradation and distinct cellular localization. ..