Gene Symbol: STP1
Description: Stp1p
Alias: BAP1, SSY2, Stp1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Boban M, Ljungdahl P. Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae. Genetics. 2007;176:2087-97 pubmed
    The yeast transcription factors Stp1 and Stp2 are synthesized as latent cytoplasmic precursors...
  2. Zargari A, Boban M, Heessen S, Andréasson C, Thyberg J, Ljungdahl P. Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2. J Biol Chem. 2007;282:594-605 pubmed
    In yeast the homologous transcription factors Stp1 and Stp2 are synthesized as latent cytoplasmic precursors with N-terminal regulatory domains...
  3. Andréasson C, Heessen S, Ljungdahl P. Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev. 2006;20:1563-8 pubmed
    The transcription factor Stp1 is endoproteolytically processed in response to extracellular amino acids by the plasma membrane SPS (Ssy1-Ptr3-Ssy5)-sensor...
  4. Tumusiime S, Zhang C, Overstreet M, Liu Z. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway. J Biol Chem. 2011;286:4620-31 pubmed publisher
    b>Stp1 and Stp2 are two homologous transcription factors activated in response to extracellular amino acid stimuli...
  5. Wang S, Stanford D, Silvers C, Hopper A. STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs. Mol Cell Biol. 1992;12:2633-43 pubmed
    b>STP1 is an unessential yeast gene involved in the removal of intervening sequences from some, but not all, families of intervening sequence-containing pre-tRNAs...
  6. Wielemans K, Jean C, Vissers S, Andre B. Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors. J Biol Chem. 2010;285:855-65 pubmed publisher
    When yeast cells detect external amino acids via their permease-like Ssy1 sensor, the cytosolic precursor forms of Stp1 and Stp2 transcription factors are activated by endoproteolytic removal of their N-terminal domains, a reaction ..
  7. Eckert Boulet N, Larsson K, Wu B, Poulsen P, Regenberg B, Nielsen J, et al. Deletion of RTS1, encoding a regulatory subunit of protein phosphatase 2A, results in constitutive amino acid signaling via increased Stp1p processing. Eukaryot Cell. 2006;5:174-9 pubmed
    ..Amino acid sensing results in proteolytic truncation of the transcription factors Stp1p and Stp2p, followed by their relocation from the cytoplasm to the nucleus, where they activate transcription of ..
  8. Menant A, Barbey R, Thomas D. Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells. EMBO J. 2006;25:4436-47 pubmed intracellular signal to a membrane initiated signaling pathway by controlling the nuclear concentration of the Stp1 transcription factor...
  9. Tanaka N, Mukai Y. Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes. Biochem Biophys Res Commun. 2015;468:32-8 pubmed publisher
    ..Tup1p bound to the promoter region of TAT1 and TAT2 genes that were dependent on STP1 and STP2 (encoding DNA-binding activator proteins) for expression...

More Information


  1. Cardillo S, Bermudez Moretti M, Correa Garcia S. Uga3 and Uga35/Dal81 transcription factors regulate UGA4 transcription in response to gamma-aminobutyric acid and leucine. Eukaryot Cell. 2010;9:1262-71 pubmed publisher
    ..Our results show that leucine affects UGA4 induction and that the SPS sensor and the downstream effectors Stp1 and Stp2 participate in this regulation...
  2. Abdel Sater F, El Bakkoury M, Urrestarazu A, Vissers S, Andre B. Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor. Mol Cell Biol. 2004;24:9771-85 pubmed
    ..Ptr3 and Ssy5 proteins, all essential to activation, by endoproteolytic processing, of the membrane-bound Stp1 transcription factor...
  3. Eckert Boulet N, Nielsen P, Friis C, dos Santos M, Nielsen J, Kielland Brandt M, et al. Transcriptional profiling of extracellular amino acid sensing in Saccharomyces cerevisiae and the role of Stp1p and Stp2p. Yeast. 2004;21:635-48 pubmed
    ..and this pathway is completely dependent on the SPS component, Ssy1p, and either of the transcription factors, Stp1p and Stp2p...
  4. Abdel Sater F, Iraqui I, Urrestarazu A, Andre B. The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Genetics. 2004;166:1727-39 pubmed
    ..amino acids, and culminates with proteolytic cleavage and translocation to the nucleus of the zinc-finger proteins Stp1 and Stp2, the lack of which abolishes induction of BAP2 and BAP3...
  5. Grauslund M, Didion T, Kielland Brandt M, Andersen H. BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae. Biochim Biophys Acta. 1995;1269:275-80 pubmed
  6. Shin C, Kim S, Huh W. TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae. J Cell Sci. 2009;122:2089-99 pubmed publisher
    ..Here, we report that degradation of Stp1, a transcription factor for amino acid uptake and a key effector of the SPS amino-acid-sensing pathway, is ..
  7. Pfirrmann T, Heessen S, Omnus D, Andréasson C, Ljungdahl P. The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1. Mol Cell Biol. 2010;30:3299-309 pubmed publisher
    Extracellular amino acids induce the yeast SPS sensor to endoproteolytically cleave transcription factors Stp1 and Stp2 in a process termed receptor-activated proteolysis (RAP)...
  8. Nielsen P, van den Hazel B, Didion T, de Boer M, Jørgensen M, Planta R, et al. Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2. Mol Gen Genet. 2001;264:613-22 pubmed
    ..Other genes that control BAP2 encode known (Leu3p, Tup1p) and putative (Stp1p, Stp2p) transcription factors...
  9. de Boer M, Nielsen P, Bebelman J, Heerikhuizen H, Andersen H, Planta R. Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. Nucleic Acids Res. 2000;28:974-81 pubmed
    ..induction is mediated via an upstream activating sequence (called UAS(aa)) in the BAP3 promoter, and dependent on Stp1p, a nuclear protein with zinc finger domains, suggesting that Stp1p is a transcription factor involved in BAP3 ..
  10. Omnus D, Ljungdahl P. Latency of transcription factor Stp1 depends on a modular regulatory motif that functions as cytoplasmic retention determinant and nuclear degron. Mol Biol Cell. 2014;25:3823-33 pubmed publisher
    The Ssy1-Ptr3-Ssy5 (SPS)-sensing pathway enables yeast to respond to extracellular amino acids. Stp1, the effector transcription factor, is synthesized as a latent cytoplasmic precursor with an N-terminal regulatory domain that restricts ..