Gene Symbol: STM1
Description: Stm1p
Alias: MPT4, Stm1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Correia H, Medina R, Hernandez A, Bustamante E, Chakraburtty K, Herrera F. Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae. Mem Inst Oswaldo Cruz. 2004;99:733-7 pubmed
    ..Here we show that AF and Stm1p share some characteristics: both bind to quadruplex and Pu triplex DNA, associates ribosomal subunits, and are ..
  2. Van Dyke N, Baby J, Van Dyke M. Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. J Mol Biol. 2006;358:1023-31 pubmed
    b>Stm1p is a Saccharomyces cerevisiae protein that has been implicated in several biological processes, ranging from apoptosis to telomere biosynthesis...
  3. Ligr M, Velten I, Frohlich E, Madeo F, Ledig M, Fröhlich K, et al. The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast. Mol Biol Cell. 2001;12:2422-32 pubmed
    We have identified the yeast gene STM1 in an overexpression screen for new proteasomal substrates...
  4. Utsugi T, Toh e A, Kikuchi Y. A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta. 1995;1263:285-8 pubmed
    A new gene (STM1; suppressor of tom1) of Saccharomyces cerevisiae was isolated by the ability to suppress the temperature sensitivity of a tom1 mutant, by increasing its gene dosage...
  5. Hayashi N, Murakami S. STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae. Mol Genet Genomics. 2002;267:806-13 pubmed
    ..A STM1 cDNA was isolated in a two-hybrid screen using CDC13 as a bait...
  6. Van Dyke M, Nelson L, Weilbaecher R, Mehta D. Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem. 2004;279:24323-33 pubmed
    ..However, more recent studies have suggested a role for Stm1p in processes ranging from antiapoptosis to telomere maintenance...
  7. Ohn T, Chiang Y, Lee D, Yao G, Zhang C, Denis C. CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4. Nucleic Acids Res. 2007;35:3002-15 pubmed
    ..These results indicate that both CAF1 and factors involved in translation are required for deadenylation. ..
  8. Hata H, Mitsui H, Liu H, Bai Y, Denis C, Shimizu Y, et al. Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. Genetics. 1998;148:571-9 pubmed
    ..isolated five multicopy suppressor genes of a pop2 deletion mutation: CCR4, DHH1 (a putative RNA helicase), PKC1, STM1, and MPT5 (multicopy suppressor of pop two)...
  9. Inada T, Winstall E, Tarun S, Yates J, Schieltz D, Sachs A. One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs. RNA. 2002;8:948-58 pubmed

More Information


  1. Balagopal V, Parker R. Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae. Genetics. 2009;181:93-103 pubmed publisher
    ..To understand the function of these factors, we identified the ribosome binding protein Stm1 as a multicopy suppressor of the temperature sensitivity of the pat1Delta strain...
  2. Katayama T, Inoue N, Torigoe H. Location of the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein. Nucleic Acids Symp Ser (Oxf). 2007;:123-4 pubmed
    Saccharomyces cerevisiae Stm1 protein (273 amino acids) is a purine motif triplex DNA-binding protein...
  3. Tian R, Hoa X, Lambert J, Pezacki J, Veres T, Figeys D. Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions. Anal Chem. 2011;83:4095-102 pubmed publisher
  4. Balagopal V, Parker R. Stm1 modulates translation after 80S formation in Saccharomyces cerevisiae. RNA. 2011;17:835-42 pubmed publisher
    ..It is often inversely related to mRNA degradation and is typically controlled during initiation. The Stm1 protein in Saccharomyces cerevisiae has been shown to interact with ribosomes, affect the interaction of eEF3 with ..
  5. Van Dyke N, Pickering B, Van Dyke M. Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation. Nucleic Acids Res. 2009;37:6116-25 pubmed publisher
    b>Stm1p is a Saccharomyces cerevisiae protein that is primarily associated with cytosolic 80S ribosomes and polysomes...
  6. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  7. Katayama T, Torigoe H. The interaction between the purine motif triplex and the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein. Nucleic Acids Symp Ser (Oxf). 2008;:111-2 pubmed publisher
    Saccharomyces cerevisiae Stm1 protein (273 amino acids) is a purine motif triplex DNA-binding protein. We have previously found that Stm(1-113) (amino acids 1-113) is the minimal domain to specifically bind with the purine motif triplex...
  8. Cuenca Bono B, García Molinero V, Pascual García P, García Oliver E, Llopis A, Rodriguez Navarro S. A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism. BMC Cell Biol. 2010;11:19 pubmed publisher
    ..These interactions suggest a role for Sus1 in gene expression during cytoplasmic mRNA metabolism in addition to its nuclear function. ..
  9. Abraham K, Chan J, Salvi J, Ho B, Hall A, Vidya E, et al. Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. Nucleic Acids Res. 2016;44:8870-8884 pubmed
  10. Estruch F, Hodge C, Rodriguez Navarro S, Cole C. Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export. J Biol Chem. 2005;280:9691-7 pubmed
    ..We proposed that Zds1p associates with the complex formed by Dbp5p, Gfd1p, and nucleoporins at the cytosolic fibrils of the nuclear pore complex and is required for optimal mRNA export. ..
  11. Smith J, Chen Q, Yatsunyk L, Nicoludis J, Garcia M, Kranaster R, et al. Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol. 2011;18:478-85 pubmed publisher
    ..These findings demonstrate that, at least in the absence of full natural capping, G4 DNA can play a positive role at telomeres in vivo. ..
  12. Zhou W, Ryan J, Zhou H. Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem. 2004;279:32262-8 pubmed
    ..Taken together, these results show that protein sumoylation is broadly involved in many cellular functions and this mass spectrometry-based proteomic approach is useful in studying the regulation of protein sumoylation in the cells. ..
  13. Van Dyke N, Chanchorn E, Van Dyke M. The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence. Biochem Biophys Res Commun. 2013;430:745-50 pubmed publisher
    ..We found that the ribosome-associated protein Stm1p greatly increases the quantity of 80S ribosomes present in quiescent yeast cells and that these ribosomes ..
  14. Salvi J, Chan J, Szafranski K, Liu T, Wu J, Olsen J, et al. Roles for Pbp1 and caloric restriction in genome and lifespan maintenance via suppression of RNA-DNA hybrids. Dev Cell. 2014;30:177-91 pubmed publisher
    ..of RNA-DNA hybrids in Pbp1-deficient cells through RNaseH overexpression, deletion of the G4DNA-stabilizing Stm1, or caloric restriction operating via RNaseH/Pif1 restores rDNA stability...
  15. van den Elzen A, Schuller A, Green R, Seraphin B. Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J. 2014;33:265-76 pubmed publisher
    ..ribosomal subunits reassociate to form a large pool of non-translating 80S ribosomes stabilized by the 'clamping' Stm1 factor. The subunits of these inactive ribosomes need to be mobilized for translation restart upon stress relief...