SRP14

Summary

Gene Symbol: SRP14
Description: RNA-binding signal recognition particle subunit SRP14
Alias: RNA-binding signal recognition particle subunit SRP14
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Brown J, Hann B, Medzihradszky K, Niwa M, Burlingame A, Walter P. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. EMBO J. 1994;13:4390-400 pubmed
    ..four of these proteins demonstrated that the yeast SRP contains homologs (termed Srp14p, Srp68p and Srp72p) of the SRP14, SRP68 and SRP72 subunits found in mammalian SRP...
  2. Strub K, Fornallaz M, Bui N. The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure. RNA. 1999;5:1333-47 pubmed
    ..domain [Alu domain homolog in yeast (Adhy)], we examined the assembly of a yeast protein homologous to mammalian SRP14 (Srp14p) and scR1 RNA. Srp14p binds as a homodimeric complex to the 5' sequences of scR1 RNA...
  3. Mason N, Ciufo L, Brown J. Elongation arrest is a physiologically important function of signal recognition particle. EMBO J. 2000;19:4164-74 pubmed
    ..elongation arrest' activity requires the SRP9/14 subunit of the particle and interactions of the C-terminus of SRP14. We have purified SRP from Saccharomyces cerevisiae and demonstrated that it too has elongation arrest activity...
  4. Rossi D, Galv√£o F, Bellato H, Boldrin P, Andrews B, Valentini S, et al. eIF5A has a function in the cotranslational translocation of proteins into the ER. Amino Acids. 2014;46:645-53 pubmed publisher
    ..These results link eIF5A function in translation with a role of SRP in the cell and may help explain the dual effects of eIF5A in differential and general translation. ..
  5. Leung E, Schneider C, Yan F, Mohi El Din H, Kudla G, Tuck A, et al. Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery. Nucleic Acids Res. 2014;42:10698-710 pubmed publisher
    ..We conclude that the RNA surveillance machinery has key roles in both SRP biogenesis and quality control of the RNA, potentially facilitating the decision between these alternative fates. ..