Gene Symbol: SPO13
Description: Spo13p
Alias: Spo13p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sullivan M, Morgan D. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007;282:19710-5 pubmed
    ..We found that the meiotic regulator Spo13 is an APC substrate that is degraded during anaphase I...
  2. Ivanov E, Korolev V, Fabre F. XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics. 1992;132:651-64 pubmed
    ..Spore inviability of xrs2 strains is rescued by a spo13 mutation, but meiotic recombination (both gene conversion and crossing over) is highly depressed in spo13 xrs2 ..
  3. Lee B, Amon A, Prinz S. Spo13 regulates cohesin cleavage. Genes Dev. 2002;16:1672-81 pubmed
    ..The budding yeast protein Spo13 plays a key role in preventing centromeric cohesin from being lost during meiosis I...
  4. Varela E, Schlecht U, Moina A, Fackenthal J, Washburn B, Niederhauser Wiederkehr C, et al. Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast. Genetics. 2010;185:841-54 pubmed publisher
    b>Spo13 is a key meiosis-specific regulator required for centromere cohesion and coorientation, and for progression through two nuclear divisions...
  5. Margolskee J. The sporulation capable (sca) mutation of Saccharomyces cerevisiae is an allele of the SIR2 gene. Mol Gen Genet. 1988;211:430-4 pubmed
    We have used the special properties of the spo13-1 mutation in order to study the regulation of yeast meiosis by the mating type loci...
  6. Ajimura M, Leem S, Ogawa H. Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics. 1993;133:51-66 pubmed
    ..The spores are, however, not viable. The mre2 and mre11 mutants produce viable spores in a spo13 background, in which meiosis I is bypassed, suggesting that these mutants are blocked at an early step in meiotic ..
  7. Katis V, Matos J, Mori S, Shirahige K, Zachariae W, Nasmyth K. Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis. Curr Biol. 2004;14:2183-96 pubmed
    ..Crucially, cohesin at centromeres is retained to allow sister centromeres to biorient at the second division. Little is known about how these meiosis I-specific events are regulated...
  8. Menees T, Roeder G. MEI4, a yeast gene required for meiotic recombination. Genetics. 1989;123:675-82 pubmed
    ..The spore inviability phenotype is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division...
  9. Shonn M, McCarroll R, Murray A. Spo13 protects meiotic cohesin at centromeres in meiosis I. Genes Dev. 2002;16:1659-71 pubmed
    In the absence of Spo13, budding yeast cells complete a single meiotic division during which sister chromatids often separate. We investigated the function of Spo13 by following chromosomes tagged with green fluorescent protein...

More Information


  1. Wagstaff J, Klapholz S, Esposito R. Meiosis in haploid yeast. Proc Natl Acad Sci U S A. 1982;79:2986-90 pubmed
    ..We have demonstrated that the ochre-suppressible mutation spo13-1 enables haploid yeast cells disomic for chromosome III and heterozygous at the mating-type locus to complete ..
  2. Rice L, Plakas C, Nickels J. Loss of meiotic rereplication block in Saccharomyces cerevisiae cells defective in Cdc28p regulation. Eukaryot Cell. 2005;4:55-62 pubmed
    ..Finally, we present evidence of a possible role for a Cdc55p-dependent protein phosphatase 2A in initiating meiotic replication. ..
  3. Kiburz B, Reynolds D, Megee P, Marston A, Lee B, Lee T, et al. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes Dev. 2005;19:3017-30 pubmed
    ..requires the 120-base-pair (bp) core centromere, the kinetochore component Bub1, and the meiosis-specific factor Spo13. Interestingly, cohesins and the kinetochore proteins Iml3 and Chl4 are necessary for Sgo1 to associate with ..
  4. Thompson D, Stahl F. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics. 1999;153:621-41 pubmed
    ..The msc (meiotic sister-chromatid recombination) mutants were quantified in spo13 meiosis with respect to meiotic unequal SCR frequency, disome segregation pattern, sporulation frequency, and ..
  5. Miyajima A, Seki M, Onoda F, Shiratori M, Odagiri N, Ohta K, et al. Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions. Mol Cell Biol. 2000;20:6399-409 pubmed
    ..The spores produced by sgs1 disruptants showed relatively high viability. The sgs1 spo13 double disruptants sporulated poorly, like the sgs1 disruptants, but spore viability was reduced much more than ..
  6. Grether M, Herskowitz I. Genetic and biochemical characterization of the yeast spo12 protein. Mol Biol Cell. 1999;10:3689-703 pubmed
    ..We also observed that two genes, BNS1 (Bypasses Need for Spo12p), which has homology to SPO12, and SPO13, whose mutant phenotype is like that of spo12, can partially suppress the meiotic defect of spo12 mutants when ..
  7. Bhargava J, Engebrecht J, Roeder G. The rec102 mutant of yeast is defective in meiotic recombination and chromosome synapsis. Genetics. 1992;130:59-69 pubmed
    ..rec102 spore lethality is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division...
  8. de los Santos T, Loidl J, Larkin B, Hollingsworth N. A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae. Genetics. 2001;159:1511-25 pubmed
    ..In spo13 diploids, red1, but not mek1, is epistatic to mms4 for sporulation and spore viability, suggesting that MMS4 may ..
  9. Kaliraman V, Mullen J, Fricke W, Bastin Shanower S, Brill S. Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev. 2001;15:2730-40 pubmed
    ..Repair of this double-strand break (DSB) by homologous recombination may be responsible for the elevated levels of sister chromatid exchange (SCE) found in BLM(-/-) cells. ..
  10. Tishkoff D, Johnson A, Kolodner R. Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1. Mol Cell Biol. 1991;11:2593-608 pubmed
    ..The interaction between sep1, rad50, and spo13 mutations suggested that SEP1 acts in meiosis in a pathway that is parallel to the RAD50 pathway.
  11. Leem S, Ogawa H. The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 1992;20:449-57 pubmed
    ..The mre4 spore lethality can be suppressed by spo13, a mutation that causes cells to bypass the reductional division...
  12. Malone R, Esposito R. Recombinationless meiosis in Saccharomyces cerevisiae. Mol Cell Biol. 1981;1:891-901 pubmed
    We have utilized the single equational meiotic division conferred by the spo13-1 mutation of Saccharomyces cerevisiae (S. Klapholtz and R. E...
  13. Zanders S, Sonntag Brown M, Chen C, Alani E. Pch2 modulates chromatid partner choice during meiotic double-strand break repair in Saccharomyces cerevisiae. Genetics. 2011;188:511-21 pubmed publisher
    ..Results from genetic epistasis analyses involving spo13?, rad54?, and mek1/MEK1 alleles and an intersister recombination reporter assay are also consistent with Pch2 ..
  14. Kamieniecki R, Shanks R, Dawson D. Slk19p is necessary to prevent separation of sister chromatids in meiosis I. Curr Biol. 2000;10:1182-90 pubmed
    ..Finally, we demonstrate that Slk19p appears to function downstream of the meiosis-specific protein Spo13p in control of sister chromatid behavior during meiosis I...
  15. He J, Chao W, Zhang Z, Yang J, Cronin N, Barford D. Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell. 2013;50:649-60 pubmed publisher
    ..We provide a structural rationalization for D box and KEN box recognition by coactivators and demonstrate that many noncanonical APC/C degrons bind APC/C coactivators at the D box coreceptor...
  16. Chepurnaya O, Kozhin S, Peshekhonov V, Korolev V. RAD58 (XRS4)--a new gene in the RAD52 epistasis group. Curr Genet. 1995;28:274-9 pubmed
    ..The spore inviability of rad58 strains is not rescued by a spo13 mutation...
  17. Rockmill B, Roeder G. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev. 1991;5:2392-404 pubmed
    ..mek1 spore inviability is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division...
  18. Mao Draayer Y, Galbraith A, Pittman D, Cool M, Malone R. Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae. Genetics. 1996;144:71-86 pubmed
    ..this paper demonstrate that neither a red nor a hop1 mutation can rescue the inviable spores produced by a rad52 spo13 strain; this phenotype helps to distinguish these two genes from other early meiotic recombination genes such as ..
  19. Malone R, Bullard S, Hermiston M, Rieger R, Cool M, Galbraith A. Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics. 1991;128:79-88 pubmed
    ..g., rad50) to rescue the meiotic lethality of a rad52 spo13 strain, we have isolated 177 mutants...
  20. Gardiner J, Bullard S, Chrome C, Malone R. Molecular and genetic analysis of REC103, an early meiotic recombination gene in yeast. Genetics. 1997;146:1265-74 pubmed
    ..defined by the rec103-1 mutation found in a selection for mutations overcoming the spore inviability of a rad52 spo13 haploid strain. Mutations in REC103 also rescue rad52 in spo13 diploids...
  21. Rockmill B, Roeder G. RED1: a yeast gene required for the segregation of chromosomes during the reductional division of meiosis. Proc Natl Acad Sci U S A. 1988;85:6057-61 pubmed
    ..the red1-1 mutant contain nonsister chromatids and the red1-1 spore inviability phenotype is alleviated in red1-1 spo13 double mutants; these results indicate that nondisjunction occurs at the first meiotic division...
  22. Mitchell A, Bowdish K. Selection for early meiotic mutants in yeast. Genetics. 1992;131:65-72 pubmed
    ..Suppressors of IME1 toxicity include recessive mutations in two genes, RIM11 and RIM16 (Regulator of Inducer of Meiosis), that are required for IME1 to activate IME2 expression. RIM11 maps near CIN4 on chromosome XIII. ..
  23. McCarroll R, Esposito R. SPO13 negatively regulates the progression of mitotic and meiotic nuclear division in Saccharomyces cerevisiae. Genetics. 1994;138:47-60 pubmed
    The meiosis-specific yeast gene SPO13 has been previously shown to be required to obtain two successive divisions in meiosis. We report here that vegetative expression of this gene causes a CDC28-dependent cell-cycle arrest at mitosis...
  24. Goldmark J, Fazzio T, Estep P, Church G, Tsukiyama T. The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell. 2000;103:423-33 pubmed
    ..Based on these findings, we propose a model for the mechanism of transcriptional repression by two distinct chromatin remodeling complexes. ..
  25. Cool M, Malone R. Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2. Mol Cell Biol. 1992;12:1248-56 pubmed
    By selecting for mutations which could rescue the meiotic lethality of a rad52 spo13 strain, we isolated several new Rec genes required relatively early in the meiotic recombination process...
  26. Lee B, Kiburz B, Amon A. Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I. Curr Biol. 2004;14:2168-82 pubmed