Gene Symbol: SOK2
Species: Saccharomyces cerevisiae S288c
Ward M, Garrett S. Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene. Mol Cell Biol. 1994;14:5619-27 pubmed
..We have isolated two new genes, SOK1 and SOK2 (suppressor of kinase), as gene dosage suppressors of the conditional growth defect of several temperature-..
Ward M, Gimeno C, Fink G, Garrett S. SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol. 1995;15:6854-63 pubmed
..Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans ..
Shenhar G, Kassir Y. A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:1603-12 pubmed
..We show that in the presence of glucose IREu functions as a negative element and that Sok2 mediates this repression activity. We show that Sok2 associates with Msn2...
Pan X, Heitman J. Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol. 2000;20:8364-72 pubmed
..In previous studies, the transcription factor Sok2 was found to negatively regulate pseudohyphal differentiation...
Batenchuk C, Tepliakova L, Kaern M. Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis. BMC Genomics. 2010;11:493 pubmed publisher
..While the method was developed for growth phenotype, it should apply equally well for other phenotypes, including the expression of fluorescent reporters. ..
Malcher M, Schladebeck S, Mösch H. The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae. Genetics. 2011;187:717-30 pubmed publisher
..controls YAK1 expression at the post-transcriptional level and that Yak1 targets the transcriptional regulators Sok2 and Phd1 to control FLO11...
Ryan O, Shapiro R, Kurat C, Mayhew D, Baryshnikova A, Chin B, et al
. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012;337:1353-6 pubmed publisher
..cerevisiae and C. albicans. ..