Gene Symbol: SNZ1
Description: pyridoxine biosynthesis protein SNZ1
Alias: pyridoxine biosynthesis protein SNZ1
Species: Saccharomyces cerevisiae S288c
Rodriguez Navarro S, Llorente B, Rodriguez Manzaneque M, Ramne A, Uber G, Marchesan D, et al
. Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast. 2002;19:1261-76 pubmed
..to clarify their physiological functions, we have undertaken a characterization of the three-membered gene families SNZ1-3 and SNO1-3...
Stolz J, Vielreicher M. Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. J Biol Chem. 2003;278:18990-6 pubmed
..We also provide evidence that of the highly conserved SNZ and SNO genes in S. cerevisiae, only the protein encoded by SNZ1 is required for vitamin B6 biosynthesis.
Padilla P, Fuge E, Crawford M, Errett A, Werner Washburne M. The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation. J Bacteriol. 1998;180:5718-26 pubmed
b>SNZ1, a member of a highly conserved gene family, was first identified through studies of proteins synthesized in stationary-phase yeast cells...
Osmani A, May G, Osmani S. The extremely conserved pyroA gene of Aspergillus nidulans is required for pyridoxine synthesis and is required indirectly for resistance to photosensitizers. J Biol Chem. 1999;274:23565-9 pubmed
..These data bring clarity to the previously confusing data on this gene family. However, a new conundrum now exists; why have highly related bacteria evolved with different pathways for pyridoxine biosynthesis? ..
Dong Y, Sueda S, Nikawa J, Kondo H. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Eur J Biochem. 2004;271:745-52 pubmed
Genes SNO1 and SNZ1 are Saccharomyces cerevisiae homologues of PDX2 and PDX1 which participate in pyridoxine synthesis in the fungus Cercospora nicotianae...
Nishizawa M, Komai T, Morohashi N, Shimizu M, Toh e A. Transcriptional repression by the Pho4 transcription factor controls the timing of SNZ1 expression. Eukaryot Cell. 2008;7:949-57 pubmed publisher
..We also found that the stationary phase-specific genes SNZ1 and SNO1, which share a common promoter, are not properly induced when Pho85 is absent...
Zhang X, Teng Y, Liu J, He Y, Zhou K, Chen Y, et al
. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010;432:445-50 pubmed publisher
..In the present study, we present the crystal structures of yeast Pdx1/Snz1, in apo-, G3P (glyceraldehyde 3-phosphate)- and PLP-bound forms, at 2.3, 1.8 and 2.2 Å (1 Å=0.1 nm) respectively...
Bean L, Dvorachek W, Braun E, Errett A, Saenz G, Giles M, et al
. Analysis of the pdx-1 (snz-1/sno-1) region of the Neurospora crassa genome: correlation of pyridoxine-requiring phenotypes with mutations in two structural genes. Genetics. 2001;157:1067-75 pubmed
..region of the Neurospora crassa genome, which contains homologs of two closely linked stationary phase genes, SNZ1 and SNO1, from Saccharomyces cerevisiae...
Kanellis P, Gagliardi M, Banath J, Szilard R, Nakada S, Galicia S, et al
. A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet. 2007;3:e134 pubmed