Gene Symbol: SMF3
Description: putative divalent metal ion transporter SMF3
Species: Saccharomyces cerevisiae S288c
Techau M, Valdez Taubas J, Popoff J, Francis R, Seaman M, Blackwell J. Evolution of differences in transport function in Slc11a family members. J Biol Chem. 2007;282:35646-56 pubmed
Cohen A, Nelson H, Nelson N. The family of SMF metal ion transporters in yeast cells. J Biol Chem. 2000;275:33388-94 pubmed
..We conclude that the Smf proteins play a major role in copper and manganese homeostasis and, under certain circumstances, Smf1p may function in iron transport into the cells. ..
Li L, Miao R, Jia X, Ward D, Kaplan J. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. J Biol Chem. 2014;289:17132-41 pubmed publisher
..Overexpression of MMT1 resulted in increased cytosolic iron whereas deletion of MMT1/MMT2 led to decreased cytosolic iron. These results support the hypothesis that Mmt1/2 function as mitochondrial iron exporters. ..
Li L, Vulpe C, Kaplan J. Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway. Biochem J. 2003;375:793-8 pubmed
..Inhibition of endocytosis or deletion of both the vacuolar iron transporters ( SMF3 and FET5 / FTH1 ) prevented hephaestin from complementing the low-iron growth phenotype of Delta fet3 cells, ..
Singh A, Kaur N, Kosman D. The metalloreductase Fre6p in Fe-efflux from the yeast vacuole. J Biol Chem. 2007;282:28619-26 pubmed
..Demonstrating a role for a vacuolar metalloreductase in Fe-efflux supports the model that iron is stored in the vacuole in the ferric state. ..
Portnoy M, Liu X, Culotta V. Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol. 2000;20:7893-902 pubmed
..three homologues of the Nramp family of metal transporters: Smf1p, Smf2p, and Smf3p, encoded by SMF1, SMF2, and SMF3, respectively...