Gene Symbol: SMC4
Description: condensin subunit SMC4
Alias: condensin subunit SMC4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Freeman L, Aragon Alcaide L, Strunnikov A. The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol. 2000;149:811-24 pubmed
    ..We characterized new mutant alleles of the genes encoding the core subunits of this complex, smc2-8 and smc4-1. Both SMC2 and SMC4 are essential for chromosome transmission in anaphase...
  2. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  3. Hirano T. SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates?. Genes Dev. 1999;13:11-9 pubmed
  4. Kao L, Wang Y, Chen Y, Tseng S, Jhang J, Chen Y, et al. Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. Mol Cell Proteomics. 2014;13:594-605 pubmed publisher
    ..We validated two events, and through functional studies we discovered that Cdc14-mediated dephosphorylation of Smc4 and Bud3 is essential for proper mitosis and cytokinesis, respectively...
  5. Lavoie B, Hogan E, Koshland D. In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol. 2002;156:805-15 pubmed
    ..Finally, we provide the first evidence of a mechanistic link between condensin and cohesin function. A model discussing the functional interplay between cohesin and condensin is presented. ..
  6. Laflamme G, Tremblay Boudreault T, Roy M, Andersen P, Bonneil E, Atchia K, et al. Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity. J Biol Chem. 2014;289:27418-31 pubmed publisher
    ..Collectively, these findings demonstrate that SMC proteins can bind to and stabilize microtubules and that SMC-microtubule interactions are essential to establish a robust system to maintain genome integrity. ..
  7. Charbin A, Bouchoux C, Uhlmann F. Condensin aids sister chromatid decatenation by topoisomerase II. Nucleic Acids Res. 2014;42:340-8 pubmed publisher
    ..Our results provide evidence that condensin prevents deleterious anaphase bridges during chromosome segregation by promoting sister chromatid decatenation. ..
  8. Stray J, Crisona N, Belotserkovskii B, Lindsley J, Cozzarelli N. The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling. J Biol Chem. 2005;280:34723-34 pubmed
    ..quot; Close packing of Smc2/4 on DNA explains the substrate protection we observed. Our results support the hypothesis that SMC proteins bind multiple DNA duplexes. ..
  9. Johzuka K, Horiuchi T. The cis element and factors required for condensin recruitment to chromosomes. Mol Cell. 2009;34:26-35 pubmed publisher
    ..Our study also suggests that recruitment of condensin onto chromosomes requires cis elements and recruiters that physically interact with condensin. ..

More Information


  1. Butylin P, Strunnikov A. [Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model]. Tsitologiia. 2008;50:788-93 pubmed
    ..This approach allowed us to find out what was the individual contribution of condensin binding sites in securing mitotic stability of the minichromosomes. ..
  2. Takahashi Y, Dulev S, Liu X, Hiller N, Zhao X, Strunnikov A. Cooperation of sumoylated chromosomal proteins in rDNA maintenance. PLoS Genet. 2008;4:e1000215 pubmed publisher
    ..In addition, binding of cohesin and condensin to rDNA is altered in the mms21-CH E3-deficient mutant. ..
  3. Pratt Hyatt M, Pai D, Haeusler R, Wozniak G, Good P, Miller E, et al. Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing. Proc Natl Acad Sci U S A. 2013;110:E3081-9 pubmed publisher
    ..These results are discussed in light of recent results showing that silencing near tRNA genes also requires chromatin modification...
  4. D Ambrosio C, Schmidt C, Katou Y, Kelly G, Itoh T, Shirahige K, et al. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev. 2008;22:2215-27 pubmed publisher
    ..This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis...
  5. Legagneux V, Cubizolles F, Watrin E. Multiple roles of Condensins: a complex story. Biol Cell. 2004;96:201-13 pubmed
    ..However, the exact contribution of each subunit remains largely elusive as well as the functional interplay between Condensin I and Condensin II. ..
  6. Wysocka M, Rytka J, Kurlandzka A. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Exp Cell Res. 2004;294:592-602 pubmed
    ..We propose that, besides its other functions, Csm1p may be involved in premeiotic DNA replication. ..
  7. Li Z, Vizeacoumar F, Bahr S, Li J, Warringer J, Vizeacoumar F, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011;29:361-7 pubmed publisher
    ..This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes. ..
  8. Haeusler R, Pratt Hyatt M, Good P, Gipson T, Engelke D. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev. 2008;22:2204-14 pubmed publisher
    ..These observations suggest a widespread role for condensin in gene organization and packaging of the interphase yeast nucleus. ..
  9. Robellet X, Thattikota Y, Wang F, Wee T, Pascariu M, Shankar S, et al. A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division. Genes Dev. 2015;29:426-39 pubmed publisher
    ..This sensitivity is imparted by multisite phosphorylation of a conserved chromatin-binding sensor, the Smc4 protein...
  10. Stray J, Lindsley J. Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA. J Biol Chem. 2003;278:26238-48 pubmed
    ..Based on these models, we propose a DNA displacement mechanism to explain how differences in geometry could affect the competitive potential of DNA. ..
  11. Eeftens J, Katan A, Kschonsak M, Hassler M, de Wilde L, Dief E, et al. Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic. Cell Rep. 2016;14:1813-8 pubmed publisher
    ..Here, we probe the topology of Smc2-Smc4 dimers of the S. cerevisiae condensin complex with high-speed atomic force microscopy (AFM) in liquid...