Gene Symbol: SLY41
Species: Saccharomyces cerevisiae S288c
Dascher C, Ossig R, Gallwitz D, Schmitt H. Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol. 1991;11:872-85 pubmed
..b>Sly41p is hydrophobic and exhibits sequence similarities with the chloroplast phosphate translocator...
Ossig R, Dascher C, Trepte H, Schmitt H, Gallwitz D. The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport. Mol Cell Biol. 1991;11:2980-93 pubmed
..Here we report that four newly discovered suppressors of YPT1 deletion (SLY1-20, SLY2, SLY12, and SLY41) to a varying degree restore ER-to-Golgi transport defects in cells lacking Ypt1p...
Kito M, Seog D, Igarashi K, Kambe Honjo H, Yoda K, Yamasaki M. Calcium and SLY genes suppress the temperature-sensitive secretion defect of Saccharomyces cerevisiae uso1 mutant. Biochem Biophys Res Commun. 1996;220:653-7 pubmed
..The common phenotype and suppression of the mutants suggest that Uso1 and Ypt1 proteins function in the same process of protein transport, i.e., targeting or fusion of the transport vesicles to the Golgi membrane. ..
Aksnes H, Osberg C, Arnesen T. N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae. PLoS ONE. 2013;8:e61012 pubmed publisher
..Furthermore, all organelle-localized substrates indicated undisrupted structures, thus suggesting that absence of NatC acetylation does not have a vast effect on organelle morphology in yeast. ..
Mukherjee I, Barlowe C. Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels. Mol Biol Cell. 2016;27:1635-49 pubmed publisher
b>SLY41 was identified as a multicopy suppressor of loss of Ypt1, a Rab GTPase essential for COPII vesicle tethering at the Golgi complex...