Gene Symbol: SLC1
Description: dynein light chain
Alias: SLC1, dynein light chain
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Dick T, Surana U, Chia W. Molecular and genetic characterization of SLC1, a putative Saccharomyces cerevisiae homolog of the metazoan cytoplasmic dynein light chain 1. Mol Gen Genet. 1996;251:38-43 pubmed
    ..the evolution and the biological roles of cytoplasmic dynein, we have identified the first non-metazoan dynein light chain 1, SLC1, in the yeast Saccharomyces cerevisiae...
  2. Stuchell Brereton M, Siglin A, Li J, Moore J, Ahmed S, Williams J, et al. Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Mol Biol Cell. 2011;22:2690-701 pubmed publisher
    ..b>Dynein light chain (LC) subunits are conserved across species; however, the molecular contribution of LCs to dynein function ..
  3. Stelter P, Kunze R, Flemming D, Höpfner D, Diepholz M, Philippsen P, et al. Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex. Nat Cell Biol. 2007;9:788-96 pubmed
    ..Here, we discovered an unexpected role for yeast dynein light chain (Dyn2) in the NPC...
  4. Hayakawa A, Babour A, Sengmanivong L, Dargemont C. Ubiquitylation of the nuclear pore complex controls nuclear migration during mitosis in S. cerevisiae. J Cell Biol. 2012;196:19-27 pubmed publisher
    ..on nuclear transport or NPC organization but strongly affected the ability of Nup159 to target the dynein light chain to the NPC. This led to defects in nuclear segregation at the onset of mitosis...
  5. Romes E, Tripathy A, Slep K. Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction. J Biol Chem. 2012;287:15862-73 pubmed publisher
    ..Our data highlight the determinants that mediate oligomerization of the Nup82 complex and promote a directed, elongated cytoplasmic fibril architecture...
  6. Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, et al. Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold. J Cell Biol. 2015;208:283-97 pubmed publisher
  7. Karpova T, Lepetit M, Cooper J. Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth. Genetics. 1993;135:693-709 pubmed
    ..The other two loci were designated slc for synthetic lethality with cap2. These loci include the mutations slc1-66, slc1-87 and slc2-107...
  8. Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
  9. Colombi P, Webster B, Fröhlich F, Lusk C. The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. J Cell Biol. 2013;203:215-32 pubmed publisher
    ..It further supports the finding that NPC inheritance, not de novo NPC assembly, is primarily responsible for controlling NPC number in daughter cells. ..

More Information


  1. Jie J, Löhr F, Barbar E. Interactions of Yeast Dynein with Dynein Light Chain and Dynactin: GENERAL IMPLICATIONS FOR INTRINSICALLY DISORDERED DUPLEX SCAFFOLDS IN MULTIPROTEIN ASSEMBLIES. J Biol Chem. 2015;290:23863-74 pubmed publisher
    ..The long distance, ligand-dependent ordering of residues reveals new elements of dynamic structure within IDP linker regions. ..
  2. DeWitt M, Chang A, Combs P, Yildiz A. Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domains. Science. 2012;335:221-5 pubmed publisher
    ..Thus, dynein moves processively without interhead coordination, a mechanism fundamentally distinct from the hand-over-hand stepping of kinesin and myosin. ..
  3. Nyarko A, Song Y, Nováček J, Zídek L, Barbar E. Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly. J Biol Chem. 2013;288:2614-22 pubmed publisher
    ..These findings extend the repertoire of functions of intrinsically disordered protein to fine-tuning and versatile assembly of higher order macromolecular complexes. ..
  4. Rao L, Romes E, Nicholas M, Brenner S, Tripathy A, Gennerich A, et al. The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization. Mol Biol Cell. 2013;24:2362-77 pubmed publisher
    ..Of interest, motor phenotypes resulting from Dyn2-Pac11 complex depletion bear similarity to a point mutation in the mammalian dynein N-terminal tail (Loa), highlighting this region as a conserved, regulatory motor element...
  5. Scarfone I, Venturetti M, Hotz M, Lengefeld J, Barral Y, Piatti S. Asymmetry of the budding yeast Tem1 GTPase at spindle poles is required for spindle positioning but not for mitotic exit. PLoS Genet. 2015;11:e1004938 pubmed publisher
    ..Thus, asymmetry of the Bub2/Bfa1/Tem1 complex is crucial to control Kar9 distribution and spindle positioning during mitosis. ..
  6. Chan A, Schummer A, Fischer S, Schröter T, Cruz Zaragoza L, Bender J, et al. Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery. Eur J Cell Biol. 2016;95:585-597 pubmed publisher
    ..We identified the dynein light chain protein Dyn2p as an additional core component of the Pex14p/Pex17p-complex...
  7. Fernandez Martinez J, Kim S, Shi Y, Upla P, Pellarin R, Gagnon M, et al. Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform. Cell. 2016;167:1215-1228.e25 pubmed publisher
    ..We suggest that this configuration efficiently captures and remodels exporting mRNP particles immediately upon reaching the cytoplasmic side of the NPC. ..