Gene Symbol: SLC1
Description: 1-acylglycerol-3-phosphate O-acyltransferase SLC1
Alias: 1-acylglycerol-3-phosphate O-acyltransferase SLC1
Species: Saccharomyces cerevisiae S288c
Athenstaedt K, Zweytick D, Jandrositz A, Kohlwein S, Daum G. Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol. 1999;181:6441-8 pubmed
..Strains with YBR177c, YMR313c, and YKL140w deleted exhibited phospholipid and/or neutral lipid patterns that were different from the wild-type strain and thus may be further candidate ORFs involved in yeast lipid metabolism. ..
Benghezal M, Roubaty C, Veepuri V, Knudsen J, Conzelmann A. SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast. J Biol Chem. 2007;282:30845-55 pubmed
..Deletion of SLC1 is not lethal and does not eliminate all microsomal 1-acylglycerol-3-phosphate O-acyltransferase activity, ..
Zou J, Katavic V, Giblin E, Barton D, MacKenzie S, Keller W, et al
. Modification of seed oil content and acyl composition in the brassicaceae by expression of a yeast sn-2 acyltransferase gene. Plant Cell. 1997;9:909-23 pubmed
A putative yeast sn-2 acyltransferase gene (SLC1-1), reportedly a variant acyltransferase that suppresses a genetic defect in sphingolipid long-chain base biosynthesis, has been expressed in a yeast SLC deletion strain...
Jain S, Stanford N, Bhagwat N, Seiler B, Costanzo M, Boone C, et al
. Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae. J Biol Chem. 2007;282:30562-9 pubmed
..In Saccharomyces cerevisiae, Slc1 has been shown to mediate this reaction, but distinct activity remains after its removal from the genome...
Tamaki H, Shimada A, Ito Y, Ohya M, Takase J, Miyashita M, et al
. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. J Biol Chem. 2007;282:34288-98 pubmed
..Phosphatidic acid (PA) is a key molecule in the phospholipid biosynthetic pathway. In Saccharomyces cerevisiae, SLC1 has been identified as the gene encoding lysophosphatidic acid acyltransferase, which catalyzes PA synthesis...
Rao S, Hildebrand D. Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene. Lipids. 2009;44:945-51 pubmed publisher
The wild type (Wt) and mutant form of yeast (sphingolipid compensation) genes, SLC1 and SLC1-1, have been shown to have lysophosphatidic acid acyltransferase (LPAT) activities (Nageic et al. in J Biol Chem 269:22156-22163, 1993)...
Nagiec M, Wells G, Lester R, Dickson R. A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase. J Biol Chem. 1993;268:22156-63 pubmed
..To begin to understand the nature of the suppressor(s) we isolated and characterized a suppressor gene, SLC1 (sphingolipid compensation)...
Vionnet C, Roubaty C, Ejsing C, Knudsen J, Conzelmann A. Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem. 2011;286:6769-79 pubmed publisher
..However, lcb1? cells, unable to make sphingoid bases and inositolphosphorylceramides, are viable if they harbor SLC1-1, a gain of function mutation in the 1-acyl-glycerol-3-phosphate acyltransferase SLC1...
Pagac M, de la Mora H, Duperrex C, Roubaty C, Vionnet C, Conzelmann A. Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae. J Biol Chem. 2011;286:36438-47 pubmed publisher
..The implications of these findings are discussed. ..