Gene Symbol: SKO1
Description: Sko1p
Alias: ACR1, Sko1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Proft M, Serrano R. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol Cell Biol. 1999;19:537-46 pubmed
    ..This URSCRE-ENA1 element requires for its repression function the yeast CREB homolog Sko1p (Acr1p) as well as the integrity of the Ssn6p-Tup1p corepressor complex...
  2. Garcia Gimeno M, Struhl K. Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol. 2000;20:4340-9 pubmed
    In Saccharomyces cerevisiae, the family of ATF/CREB transcriptional regulators consists of a repressor, Acr1 (Sko1), and two activators, Aca1 and Aca2...
  3. Pascual Ahuir A, Serrano R, Proft M. The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:16-25 pubmed
    ..ion homeostasis determinant, HAL1, is regulated by two antagonistically operating bZIP transcription factors, the Sko1p repressor and the Gcn4p activator...
  4. Proft M, Pascual Ahuir A, de Nadal E, Arino J, Serrano R, Posas F. Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. EMBO J. 2001;20:1123-33 pubmed
    ..Several genes are regulated in response to osmotic stress by Sko1, a transcriptional repressor of the ATF/CREB family...
  5. Pascual Ahuir A, Posas F, Serrano R, Proft M. Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem. 2001;276:37373-8 pubmed
    The Sko1p transcriptional repressor regulates a subset of osmoinducible stress defense genes in Saccharomyces cerevisiae by binding to cAMP-responsive elements...
  6. Proft M, Struhl K. Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell. 2002;9:1307-17 pubmed
    The yeast ATF/CREB repressor Sko1(Acr1) regulates genes that are induced upon hyperosmotic stress by recruiting the Cyc8(Ssn6)-Tup1 corepressor complex to target promoters...
  7. Proft M, Struhl K. MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell. 2004;118:351-61 pubmed
  8. Nehlin J, Carlberg M, Ronne H. Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res. 1992;20:5271-8 pubmed
    We have cloned a yeast gene, SKO1, which in high copy number suppresses lethal overexpression of cAMP-dependent protein kinase. SKO1 encodes a bZIP protein that binds to the CRE motif, TGACGTCA...
  9. Batenchuk C, Tepliakova L, Kaern M. Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis. BMC Genomics. 2010;11:493 pubmed publisher
    ..While the method was developed for growth phenotype, it should apply equally well for other phenotypes, including the expression of fluorescent reporters. ..

More Information


  1. Ju S, Tardiff D, Han H, Divya K, Zhong Q, Maquat L, et al. A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol. 2011;9:e1001052 pubmed publisher
    ..library identified five yeast DNA/RNA binding proteins, encoded by the yeast genes ECM32, NAM8, SBP1, SKO1, and VHR1, that rescue the toxicity of human FUS/TLS without changing its expression level, cytoplasmic ..
  2. Tomás Cobos L, Casadome L, Mas G, Sanz P, Posas F. Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem. 2004;279:22010-9 pubmed
    ..HXT1 through modulation of the Rgt1 transcription factor, the HOG pathway modulates HXT1 through regulation of the Sko1-Tup1-Ssn6 complex...
  3. Cook K, O Shea E. Hog1 controls global reallocation of RNA Pol II upon osmotic shock in Saccharomyces cerevisiae. G3 (Bethesda). 2012;2:1129-36 pubmed publisher
    ..The combination of reduced global transcription with a gene-specific override mechanism allows cells to rapidly switch their transcriptional program in response to stress. ..
  4. Guha N, Desai P, Vancura A. Plc1p is required for SAGA recruitment and derepression of Sko1p-regulated genes. Mol Biol Cell. 2007;18:2419-28 pubmed
    In Saccharomyces cerevisiae, many osmotically inducible genes are regulated by the Sko1p-Ssn6p-Tup1p complex...
  5. Steiner W, STEINER E. Fission yeast hotspot sequence motifs are also active in budding yeast. PLoS ONE. 2012;7:e53090 pubmed publisher
    ..cerevisiae. For one of these hotspots, M26 (also called CRE), we identify TFs, Cst6 and Sko1, that activate and inhibit the hotspot, respectively...
  6. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  7. Freeman K, Gwadz M, Shore D. Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast. Genetics. 1995;141:1253-62 pubmed
    ..SKO1/ACR1, which encodes a CREB-like repressor protein in yeast, was isolated as a high copy suppressor of the toxicity ..
  8. Vincent A, Struhl K. ACR1, a yeast ATF/CREB repressor. Mol Cell Biol. 1992;12:5394-405 pubmed
    ..By isolating mutations that alleviate the repression mediated by ATF/CREB sites, we define a new yeast gene, ACR1, which encodes an ATF/CREB transcriptional repressor...
  9. Bai C, Tesker M, Engelberg D. The yeast Hot1 transcription factor is critical for activating a single target gene, STL1. Mol Biol Cell. 2015;26:2357-74 pubmed publisher
    ..Thus Hot1 is essential for transcription of just one gene, STL1. Hot1 may represent a class of transcription factors that are essential for transcription of a very few genes or even just one. ..
  10. Hanlon S, Rizzo J, Tatomer D, Lieb J, Buck M. The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae. PLoS ONE. 2011;6:e19060 pubmed publisher
  11. Thorne T, Ho H, Huvet M, Haynes K, Stumpf M. Prediction of putative protein interactions through evolutionary analysis of osmotic stress response in the model yeast Saccharomyces cerevisae. Fungal Genet Biol. 2011;48:504-11 pubmed publisher
    ..We do find that correlated evolution provides some useful information for the prediction of protein-protein interactions, but that these alone are not sufficient to explain detectable patterns of correlated evolution. ..
  12. Kobayashi Y, Inai T, Mizunuma M, Okada I, Shitamukai A, Hirata D, et al. Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress. Biochem Biophys Res Commun. 2008;368:50-5 pubmed publisher recruitment of the Tup1-Cyc8 complex to target promoters through sequence-specific DNA-binding proteins such as Sko1, which mediates the HOG pathway-dependent regulation...
  13. Pascual Ahuir A, Proft M. The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J. 2007;26:3098-108 pubmed
    ..We show that Sch9 is required for gene expression regulated by Sko1, a transcription factor, which is directly targeted by the Hog1 MAP kinase...
  14. Proft M, Gibbons F, Copeland M, Roth F, Struhl K. Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell. 2005;4:1343-52 pubmed
    In Saccharomyces cerevisiae, the ATF/CREB transcription factor Sko1 (Acr1) regulates the expression of genes induced by osmotic stress under the control of the high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway...
  15. Denison C, Rudner A, Gerber S, Bakalarski C, Moazed D, Gygi S. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005;4:246-54 pubmed
    ..These data combine with recent works to further our understanding of the breadth and impact of protein sumoylation in a diverse array of biological processes. ..
  16. Niu W, Li Z, Zhan W, Iyer V, Marcotte E. Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae. PLoS Genet. 2008;4:e1000120 pubmed publisher
    ..Many of the genes are newly implicated in cell cycle progression, for example SKO1, RFA1, and YPR015C...