Gene Symbol: SHM1
Description: glycine hydroxymethyltransferase SHM1
Alias: SHMT1, TMP3, glycine hydroxymethyltransferase SHM1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kastanos E, Woldman Y, Appling D. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry. 1997;36:14956-64 pubmed
    ..In Saccharomyces cerevisiae, mitochondrial and cytoplasmic SHMT isozymes are encoded by distinct nuclear genes (SHM1 and SHM2)...
  2. Zelikson R, Luzzati M. Two forms of serine transhydroxymethylase, one absent in a thymidylate-less mutant in Saccharomyces cerevisiae. Eur J Biochem. 1976;64:7-13 pubmed
  3. Luzzati M. Isolation and properties of a thymidylate-less mutant in Saccharomyces cerevisiae. Eur J Biochem. 1975;56:533-8 pubmed
    A mutant, tmp3, has been isolated in Saccharomyces cerevisiae...
  4. McNeil J, McIntosh E, Taylor B, Zhang F, Tang S, Bognar A. Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. J Biol Chem. 1994;269:9155-65 pubmed
    The genes encoding both the cytosolic and mitochondrial serine hydroxymethyltransferases (SHM2 and SHM1, respectively) and a third unidentified gene of the yeast Saccharomyces cerevisiae have been isolated and their nucleotide sequences ..
  5. McNeil J, Bognar A, Pearlman R. In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae. Genetics. 1996;142:371-81 pubmed
    ..Strains of Saccharomyces cerevisiae were constructed that possess combinations of gene disruptions at the SHM1 [mitochondrial serine hydroxymethyltransferase (SHMTm)], SHM2 [cytoplasmic SHMT (SHMTc)], MIS1 [mitochondrial C1-..
  6. Kao L, Megraw T, Chae C. SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Yeast. 1996;12:1239-50 pubmed
    ..One of these suppressors, SHM1, has been characterized at the molecular level and is described herein...
  7. Koren A, Ben Aroya S, Steinlauf R, Kupiec M. Pitfalls of the synthetic lethality screen in Saccharomyces cerevisiae: an improved design. Curr Genet. 2003;43:62-9 pubmed
    ..Here, we study the nature of these mutants. We report that mutations in the HIP1 and SHM1 genes exhibit synthetic lethality with ade3 deletions...
  8. Schneider S, Campodonico E, Schwer B. Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8. J Biol Chem. 2004;279:8617-26 pubmed
    ..These findings suggest a model whereby Prp22 disrupts an RNA/protein or RNA/RNA interaction in the spliceosome that is normally stabilized by Prp8. ..
  9. Calvert M, Keck K, Ptak C, Shabanowitz J, Hunt D, Pemberton L. Phosphorylation by casein kinase 2 regulates Nap1 localization and function. Mol Cell Biol. 2008;28:1313-25 pubmed
    ..In conclusion, our data show that Nap1 phosphorylation by CK2 appears to regulate Nap1 localization and is required for normal progression through S phase. ..

More Information


  1. Osada S, Kageyama K, Ohnishi Y, Nishikawa J, Nishihara T, Imagawa M. Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae. Mol Biol Rep. 2012;39:4989-96 pubmed publisher
    ..It is thought that 6-AU decreases nucleotide levels and reduces transcription elongation. These observations suggest that the association of Asf1p and Vip1p may be implicated in transcription elongation. ..