SGF29

Summary

Gene Symbol: SGF29
Description: Sgf29p
Alias: Sgf29p
Species: Saccharomyces cerevisiae S288c
Products:     SGF29

Top Publications

  1. Lee K, Florens L, Swanson S, Washburn M, Workman J. The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complex. Mol Cell Biol. 2005;25:1173-82 pubmed
    ..Taken together, these data indicate that the expression of some genes, including ARG1, is regulated by a balance of histone H2B ubiquitylation in the cell. ..
  2. Köhler A, Schneider M, Cabal G, Nehrbass U, Hurt E. Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat Cell Biol. 2008;10:707-15 pubmed publisher
    ..Thus, Sgf73 provides a molecular scaffold to integrate the regulation of H2B ubiquitin levels, tethering of a gene to the NPC and export of mRNA. ..
  3. Powell D, Weaver C, Jennings J, McAfee K, He Y, Weil P, et al. Cluster analysis of mass spectrometry data reveals a novel component of SAGA. Mol Cell Biol. 2004;24:7249-59 pubmed
    ..Our data suggest that the role of SGF11 in transcription is independent of SAGA's histone acetyltransferase activity but may involve Ubp8p recruitment to or stabilization in SAGA. ..
  4. Lee K, Swanson S, Florens L, Washburn M, Workman J. Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin. 2009;2:2 pubmed publisher
  5. Wu P, Ruhlmann C, Winston F, Schultz P. Molecular architecture of the S. cerevisiae SAGA complex. Mol Cell. 2004;15:199-208 pubmed
    ..Our data provide insights into the molecular architecture of SAGA and imply a functional organization to the complex. ..
  6. Kassem S, Villanyi Z, Collart M. Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA. Nucleic Acids Res. 2017;45:1186-1199 pubmed publisher
  7. Shukla A, Lahudkar S, Durairaj G, Bhaumik S. Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo. Biochemistry. 2012;51:706-14 pubmed publisher
    Although Sgf29p has been biochemically implicated as a component of SAGA (Spt-Ada-Gcn5 acetyltransferase), its precise mechanism of action in transcription is not clearly understood in vivo...
  8. Hoke S, Irina Mutiu A, Genereaux J, Kvas S, Buck M, Yu M, et al. Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1. Curr Genet. 2010;56:447-65 pubmed publisher
    ..These findings demonstrate the regulatory potential of mechanisms targeting the FATC domains of PIKK proteins. ..
  9. Kamata K, Hatanaka A, Goswami G, Shinmyozu K, Nakayama J, Urano T, et al. C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function. Genes Cells. 2013;18:823-37 pubmed publisher
    ..Western blot analysis detected both the full-length and truncated forms of Spt7, suggesting that SAGA and SLIK complex formation is important for the boundary function of Sgf73. ..

More Information

Publications20

  1. García Oliver E, Pascual García P, García Molinero V, Lenstra T, Holstege F, Rodriguez Navarro S. A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA. Nucleic Acids Res. 2013;41:5655-68 pubmed publisher
    ..These results unveil a new role for Sem1 in the activation of the SAGA-dependent gene GAL1 and influencing H2B deubiquitylation. Our work provides insights into a novel functional relationship between Sem1 and the SAGA complex. ..
  2. Spedale G, Mischerikow N, Heck A, Timmers H, Pijnappel W. Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex. J Biol Chem. 2010;285:22793-9 pubmed publisher
    ..Strains mimicking constitutive SLIK formation showed increased resistance to rapamycin treatment, suggesting a role for SLIK in regulating cellular responses to nutrient stress. ..
  3. Li J, Xue X, Ruan J, Wu M, Zhu Z, Zang J. Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:902-4 pubmed publisher
    The protein Sgf29 has been identified as a subunit of the SAGA (Spt-Ada-Gcn5 acetyltransferase) histone acetyltransferase complex in Saccharomyces cerevisiae, which is conserved from yeast to humans...
  4. Durand A, Bonnet J, Fournier M, Chavant V, Schultz P. Mapping the deubiquitination module within the SAGA complex. Structure. 2014;22:1553-9 pubmed
    ..A flexible protein arm brings both subunits close enough to interact simultaneously with TBP. ..
  5. Sermwittayawong D, Tan S. SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment. EMBO J. 2006;25:3791-800 pubmed
    ..This simple model can explain SAGA's observed ability to both activate and repress transcription. ..
  6. Pray Grant M, Daniel J, Schieltz D, Yates J, Grant P. Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature. 2005;433:434-8 pubmed
    ..Our study identifies the first chromodomain that recognizes methylated histone H3 (Lys 4) and possibly identifies a larger subfamily of chromodomain proteins with similar recognition properties. ..
  7. Li S, Shogren Knaak M. The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomes. J Biol Chem. 2009;284:9411-7 pubmed publisher
  8. Han Y, Luo J, Ranish J, Hahn S. Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex. EMBO J. 2014;33:2534-46 pubmed publisher
    ..Our results provide new insight into SAGA function in gene regulation, its structural similarity with TFIID, and functional interactions between the SAGA modules. ..
  9. Setiaputra D, Ross J, Lu S, Cheng D, Dong M, Yip C. Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex. J Biol Chem. 2015;290:10057-70 pubmed publisher
    ..Our results relate information of overall SAGA structure with detailed subunit level interactions, improving our understanding of its architecture and flexibility. ..
  10. Bian C, Xu C, Ruan J, Lee K, Burke T, Tempel W, et al. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. 2011;30:2829-42 pubmed publisher
    ..b>Sgf29 is a novel component of the SAGA complex...