Gene Symbol: SFA1
Description: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
Alias: ADH5, bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Petersson A, Almeida J, Modig T, Karhumaa K, Hahn Hägerdal B, Gorwa Grauslund M, et al. A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast. 2006;23:455-64 pubmed
    ..Yeast strains overexpressing ADH6 also had a substantially higher in vivo conversion rate of HMF in both aerobic and anaerobic cultures, showing that the overexpression indeed conveyed the desired increased reduction capacity...
  2. Dickinson J, Salgado L, Hewlins M. The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem. 2003;278:8028-34 pubmed
    ..combinations of mutations affecting the seven AAD genes (putative aryl alcohol dehydrogenases), five ADH genes, and SFA1, showed that the final step of amino acid catabolism (conversion of an aldehyde to a long chain or complex alcohol) ..
  3. Foster M, Liu L, Zeng M, Hess D, Stamler J. A genetic analysis of nitrosative stress. Biochemistry. 2009;48:792-9 pubmed publisher
  4. Ida Y, Furusawa C, Hirasawa T, Shimizu H. Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. J Biosci Bioeng. 2012;113:192-5 pubmed publisher
    ..The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production. ..
  5. Wehner E, Rao E, Brendel M. Molecular structure and genetic regulation of SFA, a gene responsible for resistance to formaldehyde in Saccharomyces cerevisiae, and characterization of its protein product. Mol Gen Genet. 1993;237:351-8 pubmed
    ..SFA is predicted to code for a long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) of the yeast S. cerevisiae. ..