Gene Symbol: SET1
Description: histone methyltransferase SET1
Alias: KMT2, YTX1, histone methyltransferase SET1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Trelles Sticken E, Bonfils S, Sollier J, Geli V, Scherthan H, de La Roche Saint André C. Set1- and Clb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis. J Cell Sci. 2005;118:4985-94 pubmed
    ..Absence of the B-type cyclin Clb5 or the Set1 histone methyltransferase leads to a delay of premeiotic S phase by separate mechanisms...
  2. Boa S, Coert C, Patterton H. Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast. 2003;20:827-35 pubmed
    ..cerevisiae. Hierarchical clustering analysis of the set1(-) expression profile revealed a correspondence to that of a mad2(-) strain, suggesting that the transcriptional ..
  3. Mersman D, Du H, Fingerman I, South P, Briggs S. Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression. J Biol Chem. 2012;287:2652-65 pubmed publisher
    ..The yeast H3K4 methyltransferase complex, Set1 complex or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated ..
  4. Zhang K, Lin W, Latham J, Riefler G, Schumacher J, Chan C, et al. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell. 2005;122:723-34 pubmed
    ..We report here that this balance is modulated by the Set1 methyltransferase. Deletion of SET1 suppresses chromosome loss in ipl1-2 cells...
  5. Sollier J, Lin W, Soustelle C, Suhre K, Nicolas A, Geli V, et al. Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression. EMBO J. 2004;23:1957-67 pubmed
    The Set1 protein of Saccharomyces cerevisiae is a histone methyltransferase (HMTase) acting on lysine 4 of histone H3. Inactivation of the SET1 gene in a diploid leads to a sporulation defect...
  6. Mueller J, Canze M, Bryk M. The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae. Genetics. 2006;173:557-67 pubmed
    The Set1-containing complex, COMPASS, methylates histone H3 on lysine 4 (K4) in Saccharomyces cerevisiae...
  7. Krogan N, Dover J, Khorrami S, Greenblatt J, Schneider J, Johnston M, et al. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem. 2002;277:10753-5 pubmed
    ..the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1 of the yeast Saccharomyces cerevisiae...
  8. Nislow C, Ray E, Pillus L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell. 1997;8:2421-36 pubmed
    ..Here we present analysis of SET1, a yeast member of the trithorax gene family that was identified by sequence inspection to encode a 1080-amino acid ..
  9. Schlichter A, Cairns B. Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains. EMBO J. 2005;24:1222-31 pubmed
    Trimethylation of lysine 4 of histone H3 occurs at the 5' end of active genes and is catalyzed by Set1 in Saccharomyces cerevisiae...

More Information


  1. Roguev A, Schaft D, Shevchenko A, Pijnappel W, Wilm M, Aasland R, et al. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 2001;20:7137-48 pubmed
    ..The SET domains of the Saccharomyces cerevisiae Set1 and Drosophila trithorax proteins are closely related to each other but distinct from SUV39 and G9a...
  2. Corda Y, Schramke V, Longhese M, Smokvina T, Paciotti V, Brevet V, et al. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Nat Genet. 1999;21:204-8 pubmed
    ..We show here that the SET domain of Set1p interacts with Mec3p. Deletion of SET1 increases the viability of mec3delta mutants after DNA damage (in a process that is mostly independent of Rad53p ..
  3. Nagy P, Griesenbeck J, Kornberg R, Cleary M. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A. 2002;99:90-4 pubmed
    ..We report here the purification, molecular identification, and genetic and biochemical characterization of the Set1 protein complex that is necessary for methylation of histone H3 at lysine residue 4 in Saccharomyces cerevisiae...
  4. Foster E, Downs J. Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. J Cell Biol. 2009;184:631-8 pubmed publisher
    ..Finally, we show that strains lacking the ubiquitin ligase Bre1 are defective for H3 methylation, suggesting that there is an additional Bre1 substrate that in combination with H2B K123 facilitates H3 methylation. ..
  5. Wang S, Zhou B, Zhou J. Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter. Mol Cell Biol. 2011;31:3171-81 pubmed publisher
    ..We found that derepression of the PHO5 promoter by SET1 deletion resulted in a labile chromatin structure, allowing more binding of RNA polymerase II (Pol II) but not the ..
  6. Pinskaya M, Gourvennec S, Morillon A. H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation. EMBO J. 2009;28:1697-707 pubmed publisher
    b>Set1-dependent H3K4 di- and tri-methylation (H3K4me2/3) have been associated with active transcription. Recent data indicate that the H3K4me2/3 also plays a poorly characterized RNA-dependent repressive role...
  7. Vitaliano Prunier A, Menant A, Hobeika M, Geli V, Gwizdek C, Dargemont C. Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Nat Cell Biol. 2008;10:1365-71 pubmed publisher
    ..transcriptional activation and is required for di- and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS methyltransferase complex through a poorly characterized trans-tail pathway...
  8. Fingerman I, Wu C, Wilson B, Briggs S. Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae. J Biol Chem. 2005;280:28761-5 pubmed
    ..In Saccharomyces cerevisiae, Set1 has been identified as the sole histone methyltransferase required for histone H3 lysine 4 (Lys(4)) methylation...
  9. Santos Rosa H, Bannister A, Dehe P, Geli V, Kouzarides T. Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin. J Biol Chem. 2004;279:47506-12 pubmed
    ..The inability of Sir3p to bind methylated H3 Lys-4 tails suggests a model whereby H3 Lys-4 methylation prevents Sir3p association at euchromatic sites and therefore concentrates Sir3p at unmodified, heterochromatic regions of the genome...
  10. Sommermeyer V, Béneut C, Chaplais E, Serrentino M, Borde V. Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes. Mol Cell. 2013;49:43-54 pubmed publisher
    ..Here we show that Spp1, a conserved member of the histone H3K4 methyltransferase Set1 complex, is required for normal levels of DSB formation and is associated with chromosome axes during meiosis, ..
  11. Schramke V, Neecke H, Brevet V, Corda Y, Lucchini G, Longhese M, et al. The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes. Genes Dev. 2001;15:1845-58 pubmed
    ..We show that deletion of SET1 induces a response relayed by the signaling kinase Rad53p that leads to the MEC1/TEL1-independent ..
  12. Acquaviva L, Szekvolgyi L, Dichtl B, Dichtl B, de La Roche Saint André C, Nicolas A, et al. The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination. Science. 2013;339:215-8 pubmed publisher
    ..Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions. ..
  13. Wysocki R, Javaheri A, Allard S, Sha F, Cote J, Kron S. Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol. 2005;25:8430-43 pubmed
    ..These results indicate a key role for chromatin and methylation of histone H3 Lys 79 in yeast DNA damage signaling. ..
  14. Berretta J, Pinskaya M, Morillon A. A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae. Genes Dev. 2008;22:615-26 pubmed publisher
    ..Furthermore, the Ty1 silencing is partially mediated by histone deacetylation and requires Set1-dependent histone methylation, pointing out an analogy with heterochromatin gene silencing...
  15. Bryk M, Briggs S, Strahl B, Curcio M, Allis C, Winston F. Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Curr Biol. 2002;12:165-70 pubmed
    ..In a screen for rDNA silencing mutants, we identified a mutation in SET1, previously shown to regulate silencing at telomeres and HML...
  16. Miller T, Krogan N, Dover J, Erdjument Bromage H, Tempst P, Johnston M, et al. COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A. 2001;98:12902-7 pubmed
    ..the subunits of a protein complex in the yeast Saccharomyces cerevisiae that includes the trithorax-related protein Set1. This protein complex, which we have named COMPASS (Complex Proteins Associated with Set1), consists of seven ..
  17. Dehé P, Geli V. The multiple faces of Set1. Biochem Cell Biol. 2006;84:536-48 pubmed
    In Saccharomyces cerevisiae, H3 methylation at lysine 4 (H3K4) is mediated by Set1. Set1 is a large protein bearing a conserved RNA recognition motif in addition to its catalytic C-terminal SET domain...
  18. Ng H, Robert F, Young R, Struhl K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell. 2003;11:709-19 pubmed
    b>Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation machinery to a highly localized domain at the 5' portion of active mRNA coding regions...
  19. Terzi N, Churchman L, Vasiljeva L, Weissman J, Buratowski S. H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol. 2011;31:3569-83 pubmed publisher
    ..Both Nrd1 and the Set1 histone H3K4 methyltransferase complex interact with RNA polymerase II (Pol II) during early elongation, leading us ..
  20. Takahashi Y, Lee J, Swanson S, Saraf A, Florens L, Washburn M, et al. Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol. 2009;29:3478-86 pubmed publisher
    The multiprotein complex Set1/COMPASS is the founding member of the histone H3 lysine 4 (H3K4) methyltransferases, whose human homologs include the MLL and hSet1 complexes...
  21. Lee J, Shukla A, Schneider J, Swanson S, Washburn M, Florens L, et al. Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell. 2007;131:1084-96 pubmed
    ..the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including Cps35, the only essential subunit...
  22. Takahashi Y, Westfield G, Oleskie A, Trievel R, Shilatifard A, Skiniotis G. Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proc Natl Acad Sci U S A. 2011;108:20526-31 pubmed publisher
    ..H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively...
  23. Dehé P, Dichtl B, Schaft D, Roguev A, Pamblanco M, Lebrun R, et al. Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation. J Biol Chem. 2006;281:35404-12 pubmed
    b>Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4)...
  24. Krogan N, Dover J, Wood A, Schneider J, Heidt J, Boateng M, et al. The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell. 2003;11:721-9 pubmed
    ..Methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively, is required for silencing of expression of genes located near ..
  25. Martin G, King D, Green E, García Nieto P, Alexander R, Collins S, et al. Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. Epigenetics. 2014;9:513-22 pubmed publisher
    ..We previously determined that the budding yeast histone H4 methyltransferase Set5 functions together with Set1, the H3K4 methyltransferase, in specific cellular contexts...
  26. Latham J, Chosed R, Wang S, Dent S. Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell. 2011;146:709-19 pubmed publisher
    Histone H3K4 trimethylation by the Set1/MLL family of proteins provides a hallmark for transcriptional activity from yeast to humans. In S...
  27. Margaritis T, Oreal V, Brabers N, Maestroni L, Vitaliano Prunier A, Benschop J, et al. Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet. 2012;8:e1002952 pubmed publisher
    ..of H3K4 methylation in Saccharomyces cerevisiae by determining genome-wide expression-profiles of mutants in the Set1 complex, COMPASS, that lays down these marks...
  28. Sayou C, Millán Zambrano G, Santos Rosa H, Petfalski E, Robson S, Houseley J, et al. RNA Binding by Histone Methyltransferases Set1 and Set2. Mol Cell Biol. 2017;37: pubmed publisher
    ..with genes actively transcribed by RNA polymerase II (RNAPII) and is catalyzed by Saccharomyces cerevisiae Set1 and Set2, respectively...
  29. Ezhkova E, Tansey W. Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Mol Cell. 2004;13:435-42 pubmed
    ..These data reveal that proteasome subunits function in epigenetic gene regulation by linking chromatin modifications that establish the histone code. ..
  30. Jezek M, Gast A, Choi G, Kulkarni R, Quijote J, Graham Yooll A, et al. The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance. Epigenetics. 2017;12:93-104 pubmed publisher
    ..The H3K4 methyltransferase Set1, which is commonly linked to transcriptional activation, has been implicated in telomere silencing...
  31. Albrecht D, Ceschin J, Dompierre J, Gueniot F, Pinson B, Daignan Fornier B. Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans. Genetics. 2016;204:1447-1460 pubmed
    ..Here, we found that loss of several histone-modifying enzymes, including Bre1 (histone H2B ubiquitination) and Set1 (histone H3 lysine 4 methylation), greatly enhanced AICAR inhibition on growth via the combined effects of both the ..
  32. Li S, Swanson S, Gogol M, Florens L, Washburn M, Workman J, et al. Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism. Mol Cell. 2015;60:408-21 pubmed publisher
    ..SESAME interacts with the Set1 H3K4 methyltransferase complex, which requires SAM synthesized from SESAME, and recruits SESAME to target genes, ..
  33. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary M. Association of SET domain and myotubularin-related proteins modulates growth control. Nat Genet. 1998;18:331-7 pubmed
    ..We conclude that myotubularin-type phosphatases link SET-domain containing components of the epigenetic regulatory machinery with signalling pathways involved in growth and differentiation. ..
  34. Zheng S, Wyrick J, Reese J. Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A. Mol Cell Biol. 2010;30:3635-45 pubmed publisher
    ..Interestingly, the HAR is partially occluded by nucleosomal DNA, suggesting that the function of the H2A cross talk pathway is to restrict histone modifications to nucleosomes altered by transcription. ..
  35. Gothwal S, Patel N, Colletti M, Sasanuma H, Shinohara M, Hochwagen A, et al. The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae. Genetics. 2016;202:497-512 pubmed publisher
    ..b>Set1-dependent histone H3K4 methylation and Dot1-dependent H3K79 methylation play important roles in this process in ..
  36. Soares L, Radman Livaja M, Lin S, Rando O, Buratowski S. Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns. Cell Rep. 2014;6:961-972 pubmed publisher
    Methylation of histone H3 lysine 4 by the Set1 subunit of COMPASS correlates with active transcription. Here, we show that Set1 levels are regulated by protein degradation in response to multiple signals...
  37. Ingvarsdottir K, Edwards C, Lee M, Lee J, Schultz D, Shilatifard A, et al. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol. 2007;27:7856-64 pubmed
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes. ..
  38. Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 2006;174:1135-49 pubmed
    ..A catalytically dead Hsl7p retained wild-type interactions, implying that modification of histone H3 or H4 N termini by Gcn5p, Esa1p, Rpd3p, and Set1p, but not by Hsl7p, was needed to bypass the morphogenesis checkpoint. ..
  39. Thornton J, Westfield G, Takahashi Y, Cook M, Gao X, Woodfin A, et al. Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes Dev. 2014;28:115-20 pubmed publisher
    ..Cps35/Swd2 within COMPASS (complex of proteins associated with Set1) is considered to bridge these different processes...
  40. Martin B, McBurney K, Maltby V, Jensen K, Brind Amour J, Howe L. Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae. Genetics. 2017;205:1113-1123 pubmed publisher
  41. Bani Ismail M, Shinohara M, Shinohara A. Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast. PLoS ONE. 2014;9:e96648 pubmed publisher
    ..b>Set1 promotes H3K4 methylation while Dot1 promotes H3K79 methylation...
  42. Walter D, Matter A, Fahrenkrog B. Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae. PLoS Genet. 2014;10:e1004095 pubmed publisher
    ..In contrast, loss of H3K79 methylation due to DOT1 disruption only slightly affects yeast survival. SET1 depleted cells accumulate DNA damage and co-disruption of Dot1p, the DNA damage adaptor protein Rad9p, the ..
  43. Trésaugues L, Dehé P, Guerois R, Rodriguez Gil A, Varlet I, Salah P, et al. Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation. J Mol Biol. 2006;359:1170-81 pubmed
    The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its catalytic SET domain, a conserved RNA recognition motif (RRM1)...
  44. Soloveychik M, Xu M, Zaslaver O, Lee K, Narula A, Jiang R, et al. Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation. Sci Rep. 2016;6:37942 pubmed publisher
    ..JHD2's impact on nutrient response may reflect an ancestral role of its gene family in mediating mitochondrial regulation. ..
  45. Biswas D, Dutta Biswas R, Mitra D, Shibata Y, Strahl B, Formosa T, et al. Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. EMBO J. 2006;25:4479-89 pubmed
    ..Set2 methylates K36 of histone H3, and K36 substitutions also suppress yFACT mutations. In contrast, set1 enhances yFACT mutations. Methylation at H3 K4 by Set1 is required for set2 to suppress yFACT defects...
  46. Halbach A, Zhang H, Wengi A, Jablonska Z, Gruber I, Halbeisen R, et al. Cotranslational assembly of the yeast SET1C histone methyltransferase complex. EMBO J. 2009;28:2959-70 pubmed publisher
    While probing the role of RNA for the function of SET1C/COMPASS histone methyltransferase, we identified SET1RC (SET1 mRNA-associated complex), a complex that contains SET1 mRNA and Set1, Swd1, Spp1 and Shg1, four of the eight ..
  47. Ma Z, Atencio D, Barnes C, Defiglio H, Hanes S. Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle. Mol Cell Biol. 2012;32:3594-607 pubmed publisher
    ..Thus, Ess1 has direct effects on RNA polymerase transcription by controlling cofactor binding via conformationally induced changes in the CTD and indirect effects by influencing chromatin modification. ..
  48. Shevchenko A, Schaft D, Roguev A, Pijnappel W, Stewart A, Shevchenko A. Deciphering protein complexes and protein interaction networks by tandem affinity purification and mass spectrometry: analytical perspective. Mol Cell Proteomics. 2002;1:204-12 pubmed
    ..Concordance with the results of genome-wide two-hybrid screening was poor (14% of identified interactors overlapped) suggesting that the two approaches may provide complementary views on physical interactions within the proteome. ..
  49. Kim J, Hsu J, Smith M, Allis C. Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast. Proc Natl Acad Sci U S A. 2012;109:5779-84 pubmed publisher
    ..Altogether, these data suggest that the N-tails of core histones share previously unrecognized, potentially redundant functions that, in some cases are different from those of the widely accepted H2A/H2B and H3/H4 dimer pairs. ..
  50. Verzijlbergen K, Faber A, Stulemeijer I, van Leeuwen F. Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae. BMC Mol Biol. 2009;10:76 pubmed publisher
    ..Furthermore, the silencing defect in strains lacking Dot1 was dependent on methylation of H3K4 by Set1 and histone acetylation by Gcn5, Elp3, and Sas2 in euchromatin...
  51. D Urso A, Takahashi Y, Xiong B, Marone J, Coukos R, Randise Hinchliff C, et al. Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory. elife. 2016;5: pubmed publisher
    ..Memory requires a remodeled form of the Set1/COMPASS methyltransferase lacking Spp1, which dimethylates histone H3 lysine 4 (H3K4me2)...
  52. Weiner A, Chen H, Liu C, Rahat A, Klien A, Soares L, et al. Systematic dissection of roles for chromatin regulators in a yeast stress response. PLoS Biol. 2012;10:e1001369 pubmed publisher
    ..We followed up on one pathway, finding that Set1-dependent H3K4 methylation primarily acts as a gene repressor during multiple stresses, specifically at genes ..
  53. Law M, Ciccaglione K. Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II. Genetics. 2015;199:435-53 pubmed publisher
    ..These studies implicate the CDK8 subcomplex in fine-tuning H3 Lys4 methylation levels during pseudohyphal differentiation. ..
  54. Su W, Hsu S, Chia L, Lin J, Chang S, Jiang Z, et al. Combined Interactions of Plant Homeodomain and Chromodomain Regulate NuA4 Activity at DNA Double-Strand Breaks. Genetics. 2016;202:77-92 pubmed publisher
    ..Cells harboring the H3K4R, H3K4R, K36R, or set1Δ set2Δ mutant that disrupts H3K4 and H3K36 methylation also show very similar phenotypes to the PHD and ..
  55. Mulder K, Brenkman A, Inagaki A, van den Broek N, Timmers H. Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res. 2007;35:2428-39 pubmed
    ..These results suggest a mechanism in which the Ccr4-Not complex functions parallel to or downstream of the Bur1/2 kinase to facilitate H3K4me3 via PAF complex recruitment. ..
  56. Schibler A, Koutelou E, Tomida J, Wilson Pham M, Wang L, Lu Y, et al. Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev. 2016;30:1187-97 pubmed publisher
    ..In Saccharomyces cerevisiae, Set1 is the sole lysine methyltransferase required for mono-, di-, and trimethylation of this site...
  57. Martin D, Baetz K, Shi X, Walter K, MacDonald V, Wlodarski M, et al. The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol. 2006;26:7871-9 pubmed
    ..These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation. ..
  58. Hwang W, Madhani H. Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genet. 2009;5:e1000588 pubmed publisher
    ..The nonredundant role for these modifications in this context contrasts with the notion of a highly combinatorial code by which histone marks act to control biological processes. ..
  59. Parnell T, Schlichter A, WILSON B, Cairns B. The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. elife. 2015;4:e06073 pubmed publisher
    ..Taken together, we provide the first genetic and genomic evidence for RSC-ISW1a antagonism and reveal different mechanisms at two different promoter architectures. ..
  60. Torres Machorro A, Pillus L. Bypassing the requirement for an essential MYST acetyltransferase. Genetics. 2014;197:851-63 pubmed publisher
    ..The fact that both increased and decreased expression of the ESA1 homolog TIP60 has cancer associations in humans underscores just how important the balance of its activity is likely to be for human well-being. ..
  61. Williamson K, SCHNEIDER V, Jordan R, Mueller J, Henderson Pozzi M, Bryk M. Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1. PLoS ONE. 2013;8:e57974 pubmed publisher
    In S. cerevisiae, the lysine methyltransferase Set1 is a member of the multiprotein complex COMPASS...
  62. Nakanishi S, Lee J, Gardner K, Gardner J, Takahashi Y, Chandrasekharan M, et al. Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol. 2009;186:371-7 pubmed publisher
    ..Therefore, we generated the entire histone H2A and H2B alanine-scanning mutant strains in another background, which does not express wild-type histones. ..
  63. Nadal Ribelles M, Mas G, Millán Zambrano G, Solé C, Ammerer G, Chávez S, et al. H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes. Nucleic Acids Res. 2015;43:4937-49 pubmed publisher
    ..Here we show that the absence of H3K4 methylation, either achieved by deletion of the SET1 methyltransferase or by amino acid substitution of H3K4, bypasses the requirement of RSC for stress-responsive gene ..
  64. Morohashi N, Mitchell A, Shimizu M. Effect of histone methyltransferase gene mutations on sporulation in S. cerevisiae. Nucleic Acids Symp Ser (Oxf). 2005;:325-6 pubmed
    ..Because set1delta and set2delta affect this process additively, we suggest that Set1p and Set2p have overlapping functions in this developmental process. ..
  65. South P, Harmeyer K, Serratore N, Briggs S. H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A. Proc Natl Acad Sci U S A. 2013;110:E1016-25 pubmed publisher
    b>Set1 is a conserved histone H3 lysine 4 (H3K4) methyltransferase that exists as a multisubunit complex...
  66. Dror V, Winston F. The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae. Mol Cell Biol. 2004;24:8227-35 pubmed
    ..This repression appears to be independent of both Sir2 and Set1, two factors known to be required for rDNA silencing...