Gene Symbol: SER1
Description: O-phospho-L-serine:2-oxoglutarate transaminase
Alias: ADE9, O-phospho-L-serine:2-oxoglutarate transaminase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Melcher K, Entian K. Genetic analysis of serine biosynthesis and glucose repression in yeast. Curr Genet. 1992;21:295-300 pubmed the cat1 gene to abolish the glucose-repressible "gluconeogenic" pathway and re-isolated two mutants, ser1 and ser2, in the "glycolytic" pathway...
  2. Belhumeur P, Fortin N, Clark M. A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase. Yeast. 1994;10:385-9 pubmed
    ..In this report, we present the sequence for this yeast SERC, and evidence that its deletion from the yeast genome leads to serine dependency. The sequence has been deposited in the GenBank data library under Accession Number L20917. ..
  3. McNeil J, Bognar A, Pearlman R. In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae. Genetics. 1996;142:371-81 pubmed
    ..Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. ..
  4. Li S, Swanson S, Gogol M, Florens L, Washburn M, Workman J, et al. Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism. Mol Cell. 2015;60:408-21 pubmed publisher
    ..This leads to auto-regulation of PYK1 expression. Thus, our study provides insights into the mechanism of regulating gene expression, responding to cellular metabolism via chromatin modifications. ..
  5. Fernández Murray J, Prykhozhij S, Dufay J, Steele S, Gaston D, Nasrallah G, et al. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genet. 2016;12:e1005783 pubmed publisher
    ..Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia. ..
  6. Buc P, Rolfes R. ade9 is an allele of SER1 and plays an indirect role in purine biosynthesis. Yeast. 1999;15:1347-55 pubmed
    In this study we demonstrate that ade9 plays an indirect role in purine biosynthesis as a non-functional allele of SER1 in Saccharomyces cerevisiae...