Gene Symbol: SEC39
Alias: DSL3, Sec39p
Species: Saccharomyces cerevisiae S288c
Kraynack B, Chan A, Rosenthal E, Essid M, Umansky B, Waters M, et al
. Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell. 2005;16:3963-77 pubmed
..DSL3, recently identified in a genome wide analysis of essential genes as SEC39, encodes a cytosolic protein of 82 kDa that is peripherally associated with membranes derived from the ER...
Mnaimneh S, Davierwala A, Haynes J, Moffat J, Peng W, Zhang W, et al
. Exploration of essential gene functions via titratable promoter alleles. Cell. 2004;118:31-44 pubmed
..We identified genes involved in ribosome biogenesis (HAS1, URB1, and URB2), protein secretion (SEC39), mitochondrial import (MIM1), and tRNA charging (GSN1)...
Perry R, Mast F, Rachubinski R. Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Eukaryot Cell. 2009;8:830-43 pubmed publisher
..Tet promoter Hughes clone collection, we found that repression of the ER-associated secretory proteins Sec20p and Sec39p resulted in mislocalization of the peroxisomal matrix protein chimera Pot1p-green fluorescent protein (GFP) to the ..
Sasvari Z, Gonzalez P, Rachubinski R, Nagy P. Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein. Virology. 2013;447:21-31 pubmed publisher
..In this paper, we show that the ER-resident Sec39p vesicular transport protein is critical for the formation of active VRCs in yeast model host...
Ishikawa T, Unno K, Nonaka G, Nakajima H, Kitamoto K. Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. J Gen Appl Microbiol. 2005;51:73-82 pubmed
..Two-hybrid screening revealed the interaction of Rns1p with a transcription factor Cin5p and a functionally unknown Ylr440cp. It was observed that HA-tagged Ylr440cp was localized to the ER and nuclear envelope. ..
Diefenbacher M, Thorsteinsdóttir H, Spang A. The Dsl1 tethering complex actively participates in soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (SNARE) complex assembly at the endoplasmic reticulum in Saccharomyces cerevisiae. J Biol Chem. 2011;286:25027-38 pubmed publisher
..We provide evidence for a direct role of the Dsl1 complex, in particular Tip20p, in the formation and stabilization of ER SNARE complexes. ..
Tripathi A, Ren Y, Jeffrey P, Hughson F. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol. 2009;16:114-23 pubmed publisher
..Our results map out two alternative protein-interaction networks capable of tethering COPI-coated vesicles, via the Dsl1p complex, to ER membranes. ..
Meiringer C, Rethmeier R, Auffarth K, Wilson J, Perz A, Barlowe C, et al
. The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation. J Biol Chem. 2011;286:25039-46 pubmed publisher
..transport from the Golgi to the ER requires the Dsl1 tethering complex, which consists of the three subunits Dsl1, Dsl3, and Tip20...
Ueno K, Nagano M, Shimizu S, Toshima J, Toshima J. Lipid droplet proteins, Lds1p, Lds2p, and Rrt8p, are implicated in membrane protein transport associated with ergosterol. Biochem Biophys Res Commun. 2016;475:315-21 pubmed publisher
..Furthermore, we identified Sec39p/Dsl3p, a component of the DSL1 tethering complex that mediates the interaction with COPI vesicles, as a binding ..