Gene Symbol: SDS22
Description: type 1 protein phosphatase-activating protein SDS22
Alias: EGP1, type 1 protein phosphatase-activating protein SDS22
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Hisamoto N, Frederick D, Sugimoto K, Tatchell K, Matsumoto K. The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:3767-76 pubmed
    ..The nucleotide sequence of EGP1 predicts a leucine-rich repeat protein that is similar to Sds22, a protein from the fission yeast Schizosaccharomyces pombe that positively modulates PP1...
  2. Peggie M, MacKelvie S, Bloecher A, Knatko E, Tatchell K, Stark M. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1. J Cell Sci. 2002;115:195-206 pubmed
    ..Temperature-sensitive (Ts(-)) S. cerevisiae sds22 mutants show profound chromosome instability at elevated growth temperatures but do not confer a cell cycle stage-..
  3. Bharucha J, Larson J, Gao L, Daves L, Tatchell K. Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1032-45 pubmed publisher
    ..Ypi1 depletion is accompanied by a reduction of nuclear PP1 and by loss of nuclear Sds22, a Glc7 binding partner that is found in a ternary complex with Ypi1 and Glc7...
  4. Nigavekar S, Tan Y, Cannon J. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Arch Biochem Biophys. 2002;404:71-9 pubmed
    ..Furthermore, deletion of regulatory subunit Gac1, Reg1, Reg2, Sds22, or Glc8 had no influence on Glc7 protein half-life...
  5. Tatchell K, Makrantoni V, Stark M, Robinson L. Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proc Natl Acad Sci U S A. 2011;108:3994-9 pubmed publisher
    ..Together, our results suggest that TORC1 positively regulates the Glc7 activity that opposes Ipl1 and provide a mechanism to tie nutritional status with mitotic regulation. ..
  6. Nedea E, Nalbant D, Xia D, Theoharis N, Suter B, Richardson C, et al. The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes. Mol Cell. 2008;29:577-87 pubmed publisher
    ..Swd2 is also a subunit of the Set1c histone H3K4 methyltransferase complex and is required for its stability and optimal methyltransferase activity. ..
  7. Wu X, Tatchell K. Mutations in yeast protein phosphatase type 1 that affect targeting subunit binding. Biochemistry. 2001;40:7410-20 pubmed
    ..regulate glycogen accumulation and glucose repression, respectively, but all retain the ability to associate with Sds22, a regulatory subunit that lacks this motif...
  8. Pinsky B, Kotwaliwale C, Tatsutani S, Breed C, Biggins S. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol. 2006;26:2648-60 pubmed
    ..To identify potential Glc7 and Ipl1 substrates, we isolated ipl1-321 dosage suppressors. Seven genes (SDS22, BUD14, GIP3, GIP4, SOL1, SOL2, and PEX31) encode newly identified ipl1 dosage suppressors, and all 10 suppressors ..
  9. Pedelini L, Marquina M, Arino J, Casamayor A, Sanz L, Bollen M, et al. YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem. 2007;282:3282-92 pubmed
    ..In this work we demonstrate that Ypi1 forms a complex with Glc7 and Sds22, another Glc7 regulatory subunit that targets the phosphatase to substrates involved in cell cycle control...

More Information


  1. MacKelvie S, Andrews P, Stark M. The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase. Mol Cell Biol. 1995;15:3777-85 pubmed
    ..The gene which we have isolated (termed SDS22) encodes a product with a high degree of sequence identity to the fission yeast sds22 protein, a known regulator ..
  2. Zhang K, Lin W, Latham J, Riefler G, Schumacher J, Chan C, et al. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell. 2005;122:723-34 pubmed
    ..Moreover, our findings suggest that antagonism between lysine methylation and serine phosphorylation is a fundamental mechanism for controlling protein function. ..
  3. Ramaswamy N, Li L, Khalil M, Cannon J. Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase. Genetics. 1998;149:57-72 pubmed
    ..The Glc7p/Gip1p holoenzyme may participate in completion of meiotic divisions or spore packaging because meiotic dyads predominate when some glc7 diploids sporulate. ..
  4. Böhm S, Buchberger A. The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS ONE. 2013;8:e56486 pubmed publisher
    ..Our data suggest that the Cdc48(Shp1) complex controls Glc7 activity by regulating its interaction with Glc8 and possibly further regulatory subunits. ..
  5. Ghosh A, Cannon J. Analysis of protein phosphatase-1 and aurora protein kinase suppressors reveals new aspects of regulatory protein function in Saccharomyces cerevisiae. PLoS ONE. 2013;8:e69133 pubmed publisher
    ..This work shows that lethality requires the function of Glc7 regulatory proteins Sds22, Reg2, and phosphorylated Glc8...
  6. Hong G, Trumbly R, Reimann E, Schlender K. Sds22p is a subunit of a stable isolatable form of protein phosphatase 1 (Glc7p) from Saccharomyces cerevisiae. Arch Biochem Biophys. 2000;376:288-98 pubmed
    ..These results demonstrate that Sds22p forms a complex with Glc7p and that Sds22p:Glc7p is a stable isolatable form of yeast PP1. ..
  7. Robinson L, Phillips J, Brou L, Boswell E, Tatchell K. Suppressors of ipl1-2 in components of a Glc7 phosphatase complex, Cdc48 AAA ATPase, TORC1, and the kinetochore. G3 (Bethesda). 2012;2:1687-701 pubmed publisher
    ..include three intragenic, second-site revertants in IPL1; 17 mutations in Glc7 phosphatase components (GLC7, SDS22, YPI1); two mutations in SHP1, encoding a regulator of the AAA ATPase Cdc48; and a mutation in TCO89, encoding a ..
  8. Cheng Y, Chen R. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015;128:1180-92 pubmed publisher
    ..Mutation or depletion of the PP1 regulatory subunits Sds22 and Ypi1, which are involved in nuclear targeting of Glc7, also produce Glc7 aggregates, indicating that ..