Gene Symbol: SDO1
Description: guanine nucleotide exchange factor SDO1
Alias: guanine nucleotide exchange factor SDO1
Species: Saccharomyces cerevisiae S288c
Vitiello S, Benedict J, Padilla Lopez S, Pearce D. Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease. Hum Mol Genet. 2010;19:931-42 pubmed publisher
..Here, we report that an SDO1 deletion strain has decreased vacuolar pH and V-ATPase-dependent H(+) transport and ATP hydrolysis...
Ma C, Yan K, Tan D, Li N, Zhang Y, Yuan Y, et al
. Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation. Protein Cell. 2016;7:187-200 pubmed publisher
Boocock G, Morrison J, Popovic M, Richards N, Ellis L, Durie P, et al
. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat Genet. 2003;33:97-101 pubmed publisher
Savchenko A, Krogan N, Cort J, Evdokimova E, Lew J, Yee A, et al
. The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. J Biol Chem. 2005;280:19213-20 pubmed publisher
..Our observations, taken together with previous reports, support the conclusion that SBDS and its homologues play a role in RNA metabolism...
Gijsbers A, García Márquez A, Luviano A, Sánchez Puig N. Guanine nucleotide exchange in the ribosomal GTPase EFL1 is modulated by the protein mutated in the Shwachman-Diamond syndrome. Biochem Biophys Res Commun. 2013;437:349-54 pubmed publisher
..Efl1 is a yeast GTPase required for the cytoplasmic maturation of the 60S ribosomal subunit. Together with Sdo1, the yeast ortholog of the protein mutated in the Shwachman-Diamond Syndrome (SBDS), Efl1 releases the anti-..
Asano N, Atsuumi H, Nakamura A, Tanaka Y, Tanaka I, Yao M. Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain. Biochem Biophys Res Commun. 2014;443:1251-6 pubmed publisher
..Based on these observations together with those reported previously, we propose roles of EFL1 and SBDS in ribosomal maturation. ..
Menne T, Goyenechea B, Sánchez Puig N, Wong C, Tonkin L, Ancliff P, et al
. The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet. 2007;39:486-95 pubmed
..Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ..
Kanprasoet W, Jensen L, Sriprach S, Thitiananpakorn K, Rattanapornsompong K, Jensen A. Deletion of Mitochondrial Porin Alleviates Stress Sensitivity in the Yeast Model of Shwachman-Diamond Syndrome. J Genet Genomics. 2015;42:671-84 pubmed publisher
..stress response (ESR), heat shock response (HSR), and endoplasmic reticulum unfolded protein response (UPR) of sdo1Î” cells are functional and that defects in these pathways do not produce the phenotypes observed in sdo1Î” ..
Luz J, Georg R, Gomes C, Machado Santelli G, Oliveira C. Sdo1p, the yeast orthologue of Shwachman-Bodian-Diamond syndrome protein, binds RNA and interacts with nuclear rRNA-processing factors. Yeast. 2009;26:287-98 pubmed publisher
..Sdo1p binds RNA directly, suggesting that it may associate with the ribosomal subunits also through RNA interaction. ..