SDH3

Summary

Gene Symbol: SDH3
Description: succinate dehydrogenase cytochrome b subunit SDH3
Alias: CYB3, YKL4, succinate dehydrogenase cytochrome b subunit SDH3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. McAlister Henn L, Small W. Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol. 1997;57:317-39 pubmed
  2. Oyedotun K, Lemire B. The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. FEBS Lett. 1999;442:203-7 pubmed
    ..reductase or succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits encoded by the SDH1, SDH2, SDH3, and SDH4 genes. In most organisms, SDH contains one or two endogenous b-type hemes...
  3. Szeto S, Reinke S, Oyedotun K, Sykes B, Lemire B. Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes. J Biol Chem. 2012;287:22509-20 pubmed publisher
    ..We cloned and expressed these alternative subunits. Shh3p and Shh4p were able to complement ?sdh3 and ?sdh4 deletion mutants, respectively, and support respiratory growth. Tim18p was unable to do so...
  4. Chang Y, Hsieh M, Chang W, Wang H, Lin M, Wang C, et al. Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. Antioxid Redox Signal. 2015;22:587-602 pubmed publisher
    ..These findings reinforce our understanding of the mechanisms underlying PGL tumorigenesis and point to the yeast Shh4 as a good model to investigate the possible pathogenic relevance of SDHD in PGL polymorphisms. ..
  5. Dibrov E, Fu S, Lemire B. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). J Biol Chem. 1998;273:32042-8 pubmed
    ..SDH is encoded by the SDH1, SDH2, SDH3, and SDH4 genes. The holoenzyme is composed of two domains...
  6. Oyedotun K, Yau P, Lemire B. Identification of the heme axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase. J Biol Chem. 2004;279:9432-9 pubmed
    ..Loss of cytochrome b(562) has no effect on enzyme assembly and quinone reduction; the role of the heme in enzyme structure and function is discussed. ..
  7. Kubo Y, Takagi H, Nakamori S. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. J Biosci Bioeng. 2000;90:619-24 pubmed
    Succinate dehydrogenase (SDH) of Saccharomyces cerevisiae consists of four subunits encoded by the SDH1, SDH2, SDH3, and SDH4 genes...
  8. Oyedotun K, Sit C, Lemire B. The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction. Biochim Biophys Acta. 2007;1767:1436-45 pubmed
    ..Our results strongly suggest that heme is not required for electron transport from succinate to quinone nor is it necessary for assembly of the S. cerevisiae SDH. ..
  9. Barnard E, McFerran N, Trudgett A, Nelson J, Timson D. Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method. Fungal Genet Biol. 2008;45:597-604 pubmed publisher

More Information

Publications11

  1. Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud D, Kulawiak B, et al. Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell. 2011;44:811-8 pubmed publisher
    ..TIM22 complex) that surprisingly is identical to subunit 3 of respiratory complex II, succinate dehydrogenase (Sdh3). The membrane-integral protein Sdh3 plays specific functions in electron transfer in complex II...
  2. Szeto S, Reinke S, Sykes B, Lemire B. Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting. J Proteome Res. 2010;9:6729-39 pubmed publisher
    ..into the underlying global metabolic consequences of SDH dysfunction, we examined the metabolic footprints of SDH3 and SDH4 mutants. We identified and quantified 36 metabolites in the exometabolome...