Gene Symbol: SDH2
Description: succinate dehydrogenase iron-sulfur protein subunit SDH2
Alias: ACN17, succinate dehydrogenase iron-sulfur protein subunit SDH2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Przybyla Zawislak B, Gadde D, Ducharme K, McCammon M. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics. 1999;152:153-66 pubmed
    ..These results provide genetic evidence that NAD-IDH plays a unique role in TCA cycle function. ..
  2. Singer T, Massey V, Kearney E. Studies on succinic dehydrogenase. V. Isolation and properties of the dehydrogenase from baker's yeast. Arch Biochem Biophys. 1957;69:405-21 pubmed
  3. Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud D, Kulawiak B, et al. Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell. 2011;44:811-8 pubmed publisher
    ..We conclude that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively. ..
  4. Gonzalez Cabo P, Vázquez Manrique R, García Gimeno M, Sanz P, Palau F. Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet. 2005;14:2091-8 pubmed
    ..interaction experiments confirmed a functional relationship between YFH1 and succinate dehydrogenase genes SDH1 and SDH2. We also demonstrate a physical interaction between human frataxin and human succinate dehydrogenase complex ..
  5. Kubo Y, Takagi H, Nakamori S. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. J Biosci Bioeng. 2000;90:619-24 pubmed
    Succinate dehydrogenase (SDH) of Saccharomyces cerevisiae consists of four subunits encoded by the SDH1, SDH2, SDH3, and SDH4 genes...
  6. Breker M, Gymrek M, Schuldiner M. A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol. 2013;200:839-50 pubmed publisher
    ..These include bet-hedging strategies, organelle rearrangement, and redistribution of protein localizations. All data are available for download through our online database, LOQATE (localization and quantitation atlas of yeast proteome). ..
  7. Robinson K, von Kieckebusch Gück A, Lemire B. Isolation and characterization of a Saccharomyces cerevisiae mutant disrupted for the succinate dehydrogenase flavoprotein subunit. J Biol Chem. 1991;266:21347-50 pubmed
    ..Disruption of the flavoprotein subunit gene results in the simultaneous loss of both the iron-sulfur and the flavoprotein subunits from mitochondrial membranes. ..
  8. Dibrov E, Fu S, Lemire B. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). J Biol Chem. 1998;273:32042-8 pubmed
    ..SDH is encoded by the SDH1, SDH2, SDH3, and SDH4 genes. The holoenzyme is composed of two domains...
  9. Kim H, Jeong M, Na U, Winge D. Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit. J Biol Chem. 2012;287:40670-9 pubmed publisher
    ..The impaired assembly of SDH with the C-terminal Sdh1 mutants suggests that FAD binding is important to stabilize the Sdh1 conformation enabling association with Sdh2 and the membrane anchor subunits.

More Information


  1. Cao H, Yue M, Li S, Bai X, Zhao X, Du Y. The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2011;89:733-8 pubmed publisher
    ..In addition, the amount of ethanol produced by BS2M was slightly decreased. With the mig2 mutant BSM2, the concentrations of pyruvate and glycerol were increased by 26.23% and 15.28%, respectively, compared to the parent strain B2S. ..
  2. Rezaei M, Aslankoohi E, Verstrepen K, Courtin C. Contribution of the tricarboxylic acid (TCA) cycle and the glyoxylate shunt in Saccharomyces cerevisiae to succinic acid production during dough fermentation. Int J Food Microbiol. 2015;204:24-32 pubmed publisher
    ..By contrast, double deletion of SDH1 and SDH2 resulted in a two-fold higher succinic acid accumulation compared to the wild-type...
  3. Lin A, Anderson S, Minard K, McAlister Henn L. Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants. J Biol Chem. 2011;286:33737-46 pubmed publisher
    Cellular and mitochondrial metabolite levels were measured in yeast TCA cycle mutants (sdh2? or fum1?) lacking succinate dehydrogenase or fumarase activities...
  4. Na U, Yu W, Cox J, Bricker D, Brockmann K, Rutter J, et al. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab. 2014;20:253-66 pubmed publisher
    ..We show here that two factors, Sdh6 (SDHAF1) and Sdh7 (SDHAF3), mediate maturation of the FeS cluster SDH subunit (Sdh2/SDHB). Yeast and Drosophila lacking SDHAF3 are impaired in SDH activity with reduced levels of Sdh2...
  5. Melber A, Na U, Vashisht A, Weiler B, Lill R, Wohlschlegel J, et al. Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. elife. 2016;5: pubmed publisher
    ..Given these observations, we propose that Nfu1, assisted by Bol3, functions to facilitate Fe-S transfer from the biosynthetic apparatus to the client proteins preventing oxidative damage to [4Fe-4S] clusters. ..
  6. Zhao H, Wang Q, Liu C, Shang Y, Wen F, Wang F, et al. A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae. Genetics. 2018;208:1181-1194 pubmed publisher
    ..In summary, our studies unveiled the close relationship between mitochondria and sporulation, and uncover a novel meiosis initiation pathway that is regulated by the respiratory chain. ..
  7. Oyedotun K, Lemire B. The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. FEBS Lett. 1999;442:203-7 pubmed
    ..reductase or succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits encoded by the SDH1, SDH2, SDH3, and SDH4 genes. In most organisms, SDH contains one or two endogenous b-type hemes...