Gene Symbol: SDH1
Description: succinate dehydrogenase flavoprotein subunit SDH1
Alias: succinate dehydrogenase flavoprotein subunit SDH1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Robinson K, von Kieckebusch Gück A, Lemire B. Isolation and characterization of a Saccharomyces cerevisiae mutant disrupted for the succinate dehydrogenase flavoprotein subunit. J Biol Chem. 1991;266:21347-50 pubmed
    ..Disruption of the flavoprotein subunit gene results in the simultaneous loss of both the iron-sulfur and the flavoprotein subunits from mitochondrial membranes. ..
  2. Cao H, Yue M, Li S, Bai X, Zhao X, Du Y. The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2011;89:733-8 pubmed publisher
    ..In addition, the amount of ethanol produced by BS2M was slightly decreased. With the mig2 mutant BSM2, the concentrations of pyruvate and glycerol were increased by 26.23% and 15.28%, respectively, compared to the parent strain B2S. ..
  3. Hao H, Khalimonchuk O, Schraders M, Dephoure N, Bayley J, Kunst H, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science. 2009;325:1139-42 pubmed publisher
    ..Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor)...
  4. Kubo Y, Takagi H, Nakamori S. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. J Biosci Bioeng. 2000;90:619-24 pubmed
    Succinate dehydrogenase (SDH) of Saccharomyces cerevisiae consists of four subunits encoded by the SDH1, SDH2, SDH3, and SDH4 genes...
  5. Eletsky A, Jeong M, Kim H, Lee H, Xiao R, Pagliarini D, et al. Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site. Biochemistry. 2012;51:8475-7 pubmed publisher
    ..mitochondrial protein Sdh5 is required for the covalent attachment of flavin adenine dinucleotide (FAD) to protein Sdh1, a subunit of the heterotetrameric enzyme succinate dehydrogenase...
  6. Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud D, Kulawiak B, et al. Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell. 2011;44:811-8 pubmed publisher
    ..We conclude that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively. ..
  7. Kim H, Jeong M, Na U, Winge D. Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit. J Biol Chem. 2012;287:40670-9 pubmed publisher
    Succinate dehydrogenase (SDH) requires a covalent addition of FAD for catalytic function. Mutational analyses of Sdh1 implicate C-terminal region Arg residues involvement in covalent flavinylation and SDH assembly...
  8. Rezaei M, Aslankoohi E, Verstrepen K, Courtin C. Contribution of the tricarboxylic acid (TCA) cycle and the glyoxylate shunt in Saccharomyces cerevisiae to succinic acid production during dough fermentation. Int J Food Microbiol. 2015;204:24-32 pubmed publisher
    ..By contrast, double deletion of SDH1 and SDH2 resulted in a two-fold higher succinic acid accumulation compared to the wild-type...
  9. Colby G, Ishii Y, Tzagoloff A. Suppression of sdh1 mutations by the SDH1b gene of Saccharomyces cerevisiae. Yeast. 1998;14:1001-6 pubmed
    ..One of the plasmids (pG52/T3) contained SDH1 coding for the flavoprotein subunit of mitochondrial succinate dehydrogenase...

More Information


  1. Gonzalez Cabo P, Vázquez Manrique R, García Gimeno M, Sanz P, Palau F. Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet. 2005;14:2091-8 pubmed
    ..interaction experiments confirmed a functional relationship between YFH1 and succinate dehydrogenase genes SDH1 and SDH2...
  2. Zhu Q, Beattie D. Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones. J Biol Chem. 1988;263:193-9 pubmed
    ..The NADH dehydrogenase involved in the myxothiazol-sensitive quinone reduction faces the matrix side of the inner membrane suggesting that center o may be localized within the membrane at a similar depth as center i. ..
  3. Chen Y, Taylor E, Dephoure N, Heo J, Tonhato A, Papandreou I, et al. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012;15:348-60 pubmed publisher
    ..We suggest that Rcf1 is a member of an evolutionarily conserved protein family that acts to promote respiratory supercomplex assembly and activity. ..
  4. Na U, Yu W, Cox J, Bricker D, Brockmann K, Rutter J, et al. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab. 2014;20:253-66 pubmed publisher
    ..Yeast studies revealed that Sdh6 and Sdh7 act together to promote Sdh2 maturation by binding to a Sdh1/Sdh2 intermediate, protecting it from the deleterious effects of oxidants...
  5. Dibrov E, Fu S, Lemire B. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). J Biol Chem. 1998;273:32042-8 pubmed
    ..SDH is encoded by the SDH1, SDH2, SDH3, and SDH4 genes. The holoenzyme is composed of two domains...
  6. Singer T, Massey V, Kearney E. Studies on succinic dehydrogenase. V. Isolation and properties of the dehydrogenase from baker's yeast. Arch Biochem Biophys. 1957;69:405-21 pubmed
  7. Giancaspero T, Wait R, Boles E, Barile M. Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae--involvement of the mitochondrial FAD transporter, Flx1p. FEBS J. 2008;275:1103-17 pubmed publisher to be due to a post-transcriptional control that involves regulatory sequences located upstream of the SDH1 coding sequence...
  8. Ciriacy M. Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite derepression. Mol Gen Genet. 1977;154:213-20 pubmed
    ..They were either defective in isocitrate lyase (ic11), succinate dehydrogenase (sdh1), or malate dehydrogenase (mdh1, mdh2), mdh-mutants could not uniformely be appointed to one of the known MDH ..
  9. Kim H, Winge D. Emerging concepts in the flavinylation of succinate dehydrogenase. Biochim Biophys Acta. 2013;1827:627-36 pubmed publisher
    ..Essential in this catalysis is the covalently-linked cofactor flavin adenine dinucleotide (FAD) in subunit1 (Sdh1) of the SDH enzyme complex. The mechanism of FAD insertion and covalent attachment to Sdh1 is unknown...
  10. Van Vranken J, Bricker D, Dephoure N, Gygi S, Cox J, Thummel C, et al. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014;20:241-52 pubmed publisher
    ..Sdh8 interacts specifically with the catalytic Sdh1 subunit in the mitochondrial matrix, facilitating its association with Sdh2 and the subsequent assembly of the SDH ..