Gene Symbol: SCP1
Description: Scp1p
Alias: Scp1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Winder S, Jess T, Ayscough K. SCP1 encodes an actin-bundling protein in yeast. Biochem J. 2003;375:287-95 pubmed
    ..We have investigated the role of Scp1p in budding yeast to probe the fundamental role of this family of proteins...
  2. Goodman A, Goode B, Matsudaira P, Fink G. The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton. Mol Biol Cell. 2003;14:2617-29 pubmed
    ..Herein, we have used genetic and biochemical analyses to characterize the budding yeast member of this family, Scp1, which most closely resembles transgelin and contains one calponin homology (CH) domain...
  3. Gourlay C, Carpp L, Timpson P, Winder S, Ayscough K. A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol. 2004;164:803-9 pubmed
    ..actin dynamics, either by a specific actin allele or by deletion of a gene encoding the actin-bundling protein Scp1p, can increase lifespan by over 65%...
  4. Landgraf C, Panni S, Montecchi Palazzi L, Castagnoli L, Schneider Mergener J, Volkmer Engert R, et al. Protein interaction networks by proteome peptide scanning. PLoS Biol. 2004;2:E14 pubmed
    ..WISE can be easily extended to a variety of protein interaction domains, including those binding to modified peptides, thereby offering a powerful proteomic tool to help completing a full description of the cell interactome. ..
  5. Gheorghe D, Aghamohammadzadeh S, Smaczynska de Rooij I, Allwood E, Winder S, Ayscough K. Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis. J Biol Chem. 2008;283:15037-46 pubmed publisher
    The yeast SM22 homologue Scp1 has previously been shown to act as an actin-bundling protein in vitro...
  6. Stollar E, Garcia B, Chong P, Rath A, Lin H, Forman Kay J, et al. Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p. J Biol Chem. 2009;284:26918-27 pubmed publisher
    ..Peptide target complexes from binding partners Scp1p and Sjl2p were also characterized, revealing that the AbpSH3 uses a common extended interface for interaction with ..
  7. Prosser D, Drivas T, Maldonado Baez L, Wendland B. Existence of a novel clathrin-independent endocytic pathway in yeast that depends on Rho1 and formin. J Cell Biol. 2011;195:657-71 pubmed publisher
    ..Thus, our results reveal the existence of a second pathway for endocytosis in yeast, which suggests similarities with the RhoA-dependent endocytic pathways of mammalian cells. ..