SCH9

Summary

Gene Symbol: SCH9
Description: serine/threonine protein kinase SCH9
Alias: HRM2, KOM1, serine/threonine protein kinase SCH9
Species: Saccharomyces cerevisiae S288c
Products:     SCH9

Top Publications

  1. Pan Y, Shadel G. Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY). 2009;1:131-45 pubmed
  2. Weinberger M, Feng L, Paul A, Smith D, Hontz R, Smith J, et al. DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS ONE. 2007;2:e748 pubmed
    ..Replication stress also likely impacts the longevity of higher eukaryotes, including humans. ..
  3. Burtner C, Murakami C, Kennedy B, Kaeberlein M. A molecular mechanism of chronological aging in yeast. Cell Cycle. 2009;8:1256-70 pubmed
    ..life span extending environmental and genetic interventions, such as growth in high osmolarity media, deletion of SCH9 or RAS2, increase cellular resistance to acetic acid...
  4. Smets B, De Snijder P, Engelen K, Joossens E, Ghillebert R, Thevissen K, et al. Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9. FEMS Yeast Res. 2008;8:1276-88 pubmed publisher
    The protein kinase Sch9 is proposed to be a downstream effector of TORC1 that is required for activation of ribosome biogenesis and repression of entry into G(0)...
  5. Huang X, Liu J, Dickson R. Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet. 2012;8:e1002493 pubmed publisher
    ..The longer lifespan is due in part to a reduction in Sch9 protein kinase activity and a consequent reduction in chromosomal mutations and rearrangements and increased stress ..
  6. Pan Y, Schroeder E, Ocampo A, Barrientos A, Shadel G. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 2011;13:668-78 pubmed publisher
    ..Considering the conservation of TOR-pathway effects on life span, mitochondrial ROS signaling may be an important mechanism of longevity regulation in higher organisms. ..
  7. Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, et al. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol. 2009;186:509-23 pubmed publisher
    Oncogenes contribute to tumorigenesis by promoting growth and inhibiting apoptosis. Here we examine the function of Sch9, the Saccharomyces cerevisiae homologue of the mammalian Akt and S6 kinase, in DNA damage and genomic instability ..
  8. Kaeberlein M, Kirkland K, Fields S, Kennedy B. Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev. 2005;126:491-504 pubmed
    ..deletion mutations previously reported to increase yeast life span, we find that deletion of FOB1, deletion of SCH9, and deletion of GPA2, GPR1, or HXK2 (three genetic models of calorie restriction) significantly enhanced longevity...
  9. Huber A, French S, Tekotte H, Yerlikaya S, Stahl M, Perepelkina M, et al. Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L. EMBO J. 2011;30:3052-64 pubmed publisher
    ..Here, we show that Sch9, an AGC family kinase and direct substrate of TORC1, promotes ribosome biogenesis (Ribi) and ribosomal protein (RP) ..

More Information

Publications78

  1. Yorimitsu T, Zaman S, Broach J, Klionsky D. Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell. 2007;18:4180-9 pubmed
    ..Here, we find that the protein kinase A (PKA) and Sch9 signaling pathways regulate autophagy cooperatively in yeast...
  2. Zhang A, Shen Y, Gao W, Dong J. Role of Sch9 in regulating Ras-cAMP signal pathway in Saccharomyces cerevisiae. FEBS Lett. 2011;585:3026-32 pubmed publisher
    ..We report that Sch9 regulates PKA directly and SCH9 deletion enhances PKA activity by showing that: (1) Bcy1 predominately localized in ..
  3. Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li L, et al. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet. 2009;5:e1000467 pubmed publisher
    ..Here, we present data suggesting that yeast Tor1 and Sch9 (a homolog of the mammalian kinases Akt and S6K) is a central component of a network that controls a common set of ..
  4. Wei Y, Zheng X. Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis. Cell Cycle. 2009;8:4085-90 pubmed
    TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent transcription...
  5. Longo V, Shadel G, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012;16:18-31 pubmed publisher
    ..cerevisiae will continue to serve as a leading model organism for studying pathways relevant to human aging and disease. ..
  6. Lavoie H, Whiteway M. Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. Eukaryot Cell. 2008;7:1127-35 pubmed publisher
    ..life span (RLS) of Saccharomyces cerevisiae by mimicking calorie restriction, but the physiological consequences of SCH9 deletion are poorly understood...
  7. Swinnen E, Wilms T, Idkowiak Baldys J, Smets B, De Snijder P, Accardo S, et al. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014;25:196-211 pubmed publisher
    The Saccharomyces cerevisiae protein kinase Sch9 is an in vitro and in vivo effector of sphingolipid signaling. This study examines the link between Sch9 and sphingolipid metabolism in S...
  8. Pascual Ahuir A, Proft M. The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J. 2007;26:3098-108 pubmed
    The yeast Sch9 kinase has been implicated in the cellular adjustment to nutrient availability and in the regulation of aging. Here, we define a novel role for Sch9 in the transcriptional activation of osmostress inducible genes...
  9. Fabrizio P, Liou L, Moy V, Diaspro A, Valentine J, Gralla E, et al. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 2003;163:35-46 pubmed
    ..Chronological life-span extension in S. cerevisiae cyr1 and sch9 mutants is mediated by the stress-resistance proteins Msn2/Msn4 and Rim15...
  10. Voordeckers K, Kimpe M, Haesendonckx S, Louwet W, Versele M, Thevelein J. Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9. J Biol Chem. 2011;286:22017-27 pubmed publisher
    ..Although essential for viability, their functioning remains poorly understood. Sch9, the yeast protein kinase B and/or S6K ortholog, has been identified as one of their targets...
  11. Toda T, Cameron S, Sass P, Wigler M. SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev. 1988;2:517-27 pubmed
    A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation...
  12. Lu J, Lin Y, Sheu J, Wu J, Lee F, Chen Y, et al. Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell. 2011;146:969-79 pubmed publisher
    ..Sip2-Snf1 interaction inhibits Snf1 activity, thus decreasing phosphorylation of a downstream target, Sch9 (homolog of Akt/S6K), and ultimately leading to slower growth but extended replicative life span...
  13. Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 2009;23:1929-43 pubmed publisher
    ..Although two direct effectors of yeast TORC1 have been reported (Tap42, a regulator of PP2A phosphatases and Sch9, an AGC family kinase), the signaling pathways that couple TORC1 to its distal effectors were not well understood...
  14. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans W, Weinberger M, et al. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008;180:67-81 pubmed publisher
    ..This underscores the central role of aging in genomic instability. The deletion of SCH9 (homologous to AKT and S6K), but not CR, protects against the age-dependent defects in sgs1Delta by inhibiting ..
  15. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, et al. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008;4:e13 pubmed publisher
    ..kinase Rim15 is required for yeast chronological life span extension caused by deficiencies in Ras2, Tor1, and Sch9, and by calorie restriction...
  16. Prusty R, Keil R. SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination. Mol Genet Genomics. 2004;272:264-74 pubmed
    ..hrm2-1 mutants have decreased HOT1 activity and grow slowly. The HRM2 gene was cloned and found to be identical to SCH9, a gene that affects a growth-control mechanism that is partially redundant with the cAMP-dependent protein kinase ..
  17. Roosen J, Engelen K, Marchal K, Mathys J, Griffioen G, Cameroni E, et al. PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol. 2005;55:862-80 pubmed
    In the yeast Saccharomyces cerevisiae, PKA and Sch9 exert similar physiological roles in response to nutrient availability. However, their functional redundancy complicates to distinguish properly the target genes for both kinases...
  18. Jorgensen P, Rupes I, Sharom J, Schneper L, Broach J, Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 2004;18:2491-505 pubmed
    ..Here, we show that two potent negative regulators of Start, Sfp1 and Sch9, are activators of the ribosomal protein (RP) and ribosome biogenesis (Ribi) regulons, the transcriptional programs ..
  19. Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, et al. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell. 2007;26:663-74 pubmed
    ..Here we report that the AGC kinase Sch9 is a substrate of yeast TORC1. Six amino acids in the C terminus of Sch9 are directly phosphorylated by TORC1...
  20. Swinnen E, Rosseels J, Winderickx J. The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses. Curr Genet. 2005;48:18-33 pubmed
    ..Finally, we present data supporting that the PHO pathway functions in parallel to the fermentable growth medium- or Sch9-controlled pathway and that both pathways may share the protein kinase Rim15, which was previously reported to play ..
  21. Fabrizio P, Pozza F, Pletcher S, Gendron C, Longo V. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 2001;292:288-90 pubmed
    ..long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold...
  22. Liu K, Zhang X, Lester R, Dickson R. The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. J Biol Chem. 2005;280:22679-87 pubmed
    ..We also demonstrate for the first time that Pkh1 phosphorylates the Sch9 protein kinase in vitro and that such phosphorylation is stimulated by PHS...
  23. Lee J, Moir R, Willis I. Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway. J Biol Chem. 2009;284:12604-8 pubmed publisher
    ..we present additional evidence for this view and show that a parallel nutrient and stress-sensing pathway involving Sch9, an homologous kinase to metazoan S6 kinase, targets Maf1 at a subset of PKA sites...
  24. Roelants F, Torrance P, Thorner J. Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9. Microbiology. 2004;150:3289-304 pubmed
    ..A fourth protein kinase involved in growth control and stress response, Sch9 (orthologue of mammalian protein kinase c-Akt/PKB), also carries the conserved activation loop motif...
  25. Jimeno S, Tous C, García Rubio M, Ranes M, González Aguilera C, Marin A, et al. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Biol. 2011;31:674-85 pubmed publisher
    ..This has permitted us to identify mutations in the genes for the RNA polymerase II mediator component Med10, the Sch9 protein kinase, and the Ypr045c protein...
  26. Acker J, Nguyen N, Vandamme M, Tavenet A, Briand Suleau A, Conesa C. Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle. PLoS ONE. 2014;9:e114587 pubmed publisher
    ..state is impaired in the absence of Sub1 resulting in a premature death that is dependent on the Ras/PKA and Tor1/Sch9 signalling pathways...
  27. Tosti E, Katakowski J, Schaetzlein S, Kim H, Ryan C, Shales M, et al. Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. Genome Med. 2014;6:68 pubmed publisher
    ..Moreover, we provide novel insights into the genome maintenance functions of a critical DNA repair complex and propose a promising targeted treatment for MMR deficient tumors. ..
  28. Teixeira V, Medeiros T, Vilaça R, Pereira A, Chaves S, Côrte Real M, et al. Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells. Cell Signal. 2015;27:1840-9 pubmed publisher
  29. Waliullah T, Yeasmin A, Kaneko A, Koike N, Terasawa M, Totsuka T, et al. Rim15 and Sch9 kinases are involved in induction of autophagic degradation of ribosomes in budding yeast. Biosci Biotechnol Biochem. 2017;81:307-310 pubmed publisher
    ..Rim15 protein kinase upregulated ribophagy, while it downregulated non-selective degradation of ribosomes. ..
  30. Mudholkar K, Fitzke E, Prinz C, Mayer M, Rospert S. The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway. Nat Commun. 2017;8:937 pubmed publisher
    ..Here we establish that Ssb is causally linked to the regulation of ribosome biogenesis via the TORC1-Sch9 signaling pathway...
  31. Takeda E, Jin N, Itakura E, Kira S, Kamada Y, Weisman L, et al. Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress. Mol Biol Cell. 2018;29:510-522 pubmed publisher
    ..Here we show that the serine/threonine protein kinase Sch9 branch of TORC1 signaling depends specifically on the integrity of the vacuolar membrane, and this dependency ..
  32. Trott A, Shaner L, Morano K. The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics. 2005;170:1009-21 pubmed
    The Sch9 protein kinase regulates Hsp90-dependent signal transduction activity in the budding yeast Saccharomyces cerevisiae. Hsp90 functions in concert with a number of cochaperones, including the Hsp110 homolog Sse1...
  33. Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, et al. Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell. 2009;33:704-16 pubmed publisher
    ..Sfp1, in turn, negatively regulates TORC1 phosphorylation of Sch9, another key TORC1 target that acts in parallel with Sfp1, revealing a feedback mechanism controlling the activity ..
  34. Bohovych I, Kastora S, Christianson S, Topil D, Kim H, Fangman T, et al. Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses. Mol Cell Biol. 2016;36:2300-12 pubmed publisher
  35. Rozario D, Siede W. Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated. Biochem Biophys Res Commun. 2012;417:1182-7 pubmed publisher
  36. Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, et al. Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ. 2005;12:668-77 pubmed
    ..These data disclose an unanticipated mechanism by which constitutive phosphorylation by CK2 may be required for maximal activation of Akt/PKB. ..
  37. Kraakman L, Lemaire K, Ma P, Teunissen A, Donaton M, Van Dijck P, et al. A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol. 1999;32:1002-12 pubmed
    ..Hence, an alternative glucose-sensing system must signal glucose availability for the Sch9-dependent pathway during growth on glucose...
  38. Kawai S, Urban J, Piccolis M, Panchaud N, De Virgilio C, Loewith R. Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae. Eukaryot Cell. 2011;10:1367-9 pubmed publisher
    TORC1-dependent phosphorylation of Saccharomyces cerevisiae Sch9 was dramatically reduced upon exposure to a protonophore or in respiration-incompetent ?(0) cells but not in respiration-incompetent pet mutants, providing important insight ..
  39. Millet C, Ausiannikava D, Le Bihan T, Granneman S, Makovets S. Cell populations can use aneuploidy to survive telomerase insufficiency. Nat Commun. 2015;6:8664 pubmed publisher
    ..The aneuploidy-induced re-balance of the proteome via modulation of ribosome biogenesis may be a general adaptive response to overcome functional insufficiencies. ..
  40. Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, et al. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol. 2014;91:438-51 pubmed publisher
    ..Notably, deletion of PKH1 or SCH9 suppressed ncr1? phenotypes but downregulation of de novo sphingolipid biosynthesis had no protective effect, ..
  41. Sasaki T, Toh e A, Kikuchi Y. Extragenic suppressors that rescue defects in the heat stress response of the budding yeast mutant tom1. Mol Gen Genet. 2000;262:940-8 pubmed
    ..These were classified into eight complementation groups and six of the genes were identified: tmr1/cyr1, tmnr2/sch9, tmr3/zuo1, tmr4, tmr5/mot1, tmr6/sse1, tmr7 and tmr8/kre6...
  42. Mirisola M, Taormina G, Fabrizio P, Wei M, Hu J, Longo V. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014;10:e1004113 pubmed publisher
    ..Serine, threonine and valine activated a signaling network in which Sch9 integrates TORC1 and Pkh signaling via phosphorylation of threonines 570 and 737 and promoted intracellular ..
  43. Kingsbury J, Sen N, Maeda T, Heitman J, Cardenas M. Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. Genetics. 2014;196:1077-89 pubmed publisher
    ..TORC1 promotes cell growth via Sch9, a p70(S6) kinase ortholog...
  44. Picazo C, Orozco H, Matallana E, Aranda A. Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions. PLoS ONE. 2015;10:e0117267 pubmed publisher
    ..e. dietary restriction, expands CLS through the control of nutrient signaling pathways, of which TOR/Sch9 has proven to be the most relevant, particularly under nitrogen deprivation...
  45. Oliveira A, Ludwig C, Zampieri M, Weisser H, Aebersold R, Sauer U. Dynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis. Sci Signal. 2015;8:rs4 pubmed publisher
    ..Finally, we identified the TORC1 substrates Sch9 and Atg1 as candidate kinases that phosphorylate Amd1 and Hom3, respectively.
  46. Qie B, Lyu Z, Lyu L, Liu J, Gao X, Liu Y, et al. Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox Biol. 2015;5:290-300 pubmed publisher
    ..Deletion of SCH9, a gene encoding a key protein kinase for longevity control, decreased the level of ubiquitinated proteins in log ..
  47. Peggion C, Lopreiato R, Casanova E, Ruzzene M, Facchin S, Pinna L, et al. Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily. FEBS J. 2008;275:5919-33 pubmed publisher
    ..A similar relationship has already been observed in humans between Akt/PKB and p53-related protein kinase (Bud32p homolog), and could indicate that this pathway is conserved throughout evolution. ..
  48. Jin Y, Weisman L. The vacuole/lysosome is required for cell-cycle progression. elife. 2015;4: pubmed publisher
    ..Furthermore, this role for the vacuole in cell-cycle progression requires an intact TORC1-SCH9 pathway that can only signal from a mature vacuole...
  49. Orlandi I, Stamerra G, Strippoli M, Vai M. During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent. Redox Biol. 2017;12:745-754 pubmed publisher
    ..This leads to a reduction in the amount of the acetylated active form of Pck1, whose enzymatic activity is essential for gluconeogenesis and CLS extension. ..
  50. Binda M, Péli Gulli M, Bonfils G, Panchaud N, Urban J, Sturgill T, et al. The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell. 2009;35:563-73 pubmed publisher
    ..Thus, in addition to its regulatory role in homotypic vacuolar fusion and vacuole protein sorting within the HOPS complex, Vam6 also controls TORC1 function by activating the Gtr1 subunit of the EGO complex. ..
  51. Moir R, Lee J, Willis I. Recovery of RNA polymerase III transcription from the glycerol-repressed state: revisiting the role of protein kinase CK2 in Maf1 phosphoregulation. J Biol Chem. 2012;287:30833-41 pubmed publisher
    ..regulated at seven phosphosites by the overlapping action of protein kinase A (PKA) and the TORC1-regulated kinase Sch9. Under stress conditions, Maf1 is dephosphorylated at these sites leading to its nuclear accumulation, increased ..
  52. Hartley A, Ward M, Garrett S. The Yak1 protein kinase of Saccharomyces cerevisiae moderates thermotolerance and inhibits growth by an Sch9 protein kinase-independent mechanism. Genetics. 1994;136:465-74 pubmed
    ..with the loss of yeast A kinase activity can be alleviated by the overexpression or deletion of two other kinases, Sch9 and Yak1, respectively...
  53. Zaman S, Lippman S, Schneper L, Slonim N, Broach J. Glucose regulates transcription in yeast through a network of signaling pathways. Mol Syst Biol. 2009;5:245 pubmed publisher
    ..changes can be recapitulated by the activation of protein kinase A (PKA) or by the induction of PKB (Sch9)...
  54. Raffaghello L, Lee C, Safdie F, Wei M, Madia F, Bianchi G, et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008;105:8215-20 pubmed publisher
  55. Morano K, Thiele D. The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J. 1999;18:5953-62 pubmed
    ..capable of restoring high-temperature growth to HSF(1-583) cells was identified, harboring a disruption of the SCH9 protein kinase gene, homologous to the protein kinase A and protein kinase B/Akt families of mammalian growth ..
  56. Albert B, Knight B, Merwin J, Martin V, Ottoz D, Gloor Y, et al. A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis. Mol Cell. 2016;64:720-733 pubmed publisher
    ..We present evidence that RNA polymerase I activity inhibits the ability of Utp22 to titrate Ifh1 from RPG promoters and propose that a dynamic Ifh1-Utp22 interaction fine-tunes RPG expression to coordinate RPG and rRNA transcription. ..
  57. Liko D, Conway M, Grunwald D, Heideman W. Stb3 plays a role in the glucose-induced transition from quiescence to growth in Saccharomyces cerevisiae. Genetics. 2010;185:797-810 pubmed publisher
    ..b>SCH9 overexpression or PPH22 deletion, mutations that activate target of rapamycin (Tor) nutrient sensing pathways, also ..
  58. Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, et al. Caffeine extends yeast lifespan by targeting TORC1. Mol Microbiol. 2008;69:277-85 pubmed publisher
    ..cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 (TORC1), Sch9, protein kinase A (PKA) and Rim15...
  59. Zhang A, Gao W. Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2012;331:10-6 pubmed publisher
    In this study, we investigated the mechanisms of Sch9 regulating the localization and phosphorylation of Bcy1...
  60. Wilms T, Swinnen E, Eskes E, Dolz Edo L, Uwineza A, Van Essche R, et al. The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability. PLoS Genet. 2017;13:e1006835 pubmed publisher
    The conserved protein kinase Sch9 is a central player in the nutrient-induced signaling network in yeast, although only few of its direct substrates are known...
  61. Liu J, He M, Peng J, Duan Y, Lu Y, Wu Z, et al. Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast. Aging (Albany NY). 2016;8:2827-2847 pubmed publisher
    ..Importantly, inactivation of Sch9, a downstream kinase of the target of rapamycin complex 1 (TORC1), suppressed both the genome instability and ..
  62. Patury S, Geda P, Dobry C, Kumar A, Gestwicki J. Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization. Cell Biochem Biophys. 2009;53:127-34 pubmed publisher
    ..Collectively, these studies provide a necessary framework for the design of large-scale applications. ..
  63. Cocklin R, Goebl M. Nutrient sensing kinases PKA and Sch9 phosphorylate the catalytic domain of the ubiquitin-conjugating enzyme Cdc34. PLoS ONE. 2011;6:e27099 pubmed publisher
    ..Here we demonstrate that the nutrient sensing kinases PKA and Sch9 phosphorylate S97 of Cdc34...
  64. Lu Y, Swamy K, Leu J. Experimental Evolution Reveals Interplay between Sch9 and Polyploid Stability in Yeast. PLoS Genet. 2016;12:e1006409 pubmed publisher
    ..We show that robust tetraploidy is achieved in evolved yeast cells by increasing the abundance of Sch9-a protein kinase activated by the TORC1 (Target of Rapamycin Complex 1) and other signaling pathways...
  65. Teixeira V, Medeiros T, Vilaça R, Ferreira J, Moradas Ferreira P, Costa V. Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells. Biochim Biophys Acta. 2016;1861:21-33 pubmed publisher
    ..These results support a model in which Sit4p functions downstream of Isc1p in a TORC1-independent, ceramide-dependent signaling branch that impairs vacuolar function and vesicular trafficking, leading to autophagic defects in yeast. ..
  66. Niles B, Mogri H, Hill A, Vlahakis A, Powers T. Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proc Natl Acad Sci U S A. 2012;109:1536-41 pubmed publisher
    ..These findings both extend the scope of cellular processes regulated by Ypk1/2 to include negative regulation of calcineurin and broaden the repertoire of mechanisms for membrane recruitment and activation of a protein kinase. ..
  67. Kimpe M, Voordeckers K, Thevelein J, Van Zeebroeck G. Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2? system. Biochem Biophys Res Commun. 2012;419:89-94 pubmed publisher
    ..Hence, the physiological importance of the close interactions between Pkh1 and Gcn2 or eIF2 could depend on other conditions and/or other targets of the Gcn2/eIF2 system. ..
  68. Cai Y, Wei Y. Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9. Aging (Albany NY). 2015;7:133-43 pubmed
    The Protein kinase A (PKA) and Sch9 regulates cell growth as well as lifespan in Saccharomyces cerevisiae. Maf1 is a RNA polymerase III (PolIII) inhibitor that tailors 5S rRNA and tRNA production in response to various environmental cues...
  69. Shimada K, Filipuzzi I, Stahl M, Helliwell S, Studer C, Hoepfner D, et al. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Mol Cell. 2013;51:829-39 pubmed publisher
    ..These phenocopy TORC2 inhibition on Zeocin, although modulation of calcineurin-sensitive transcription does not. These results implicate TORC2-mediated actin filament regulation in the survival of low levels of DNA damage. ..