Gene Symbol: SAT4
Description: serine/threonine protein kinase SAT4
Alias: HAL4, serine/threonine protein kinase SAT4
Species: Saccharomyces cerevisiae S288c
Perez Valle J, Jenkins H, Merchan S, Montiel V, Ramos J, Sharma S, et al
. Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters. Mol Cell Biol. 2007;27:5725-36 pubmed
..intracellular K+ levels and positively regulated by two redundant "halotolerance" protein kinases, Sat4/Hal4 and Hal5...
Perez Valle J, Rothe J, Primo C, Martínez Pastor M, Arino J, Pascual Ahuir A, et al
. Hal4 and Hal5 protein kinases are required for general control of carbon and nitrogen uptake and metabolism. Eukaryot Cell. 2010;9:1881-90 pubmed publisher
The yeast protein kinases Sat4/Hal4 and Hal5 are required for the plasma membrane stability of the K(+) transporter Trk1 and some amino acid and glucose permeases...
Hirasaki M, Horiguchi M, Numamoto M, Sugiyama M, Kaneko Y, Nogi Y, et al
. Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state. J Biosci Bioeng. 2011;111:249-54 pubmed publisher
..Among the 102 viable pkase disruptions, disruption of either SAT4 or HAL5 suppressed the caffeine sensitivity phenotype and increased expression of ENA1, encoding a P-type ATPase of ..
Mulet J, Leube M, Kron S, Rios G, Fink G, Serrano R. A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mol Cell Biol. 1999;19:3328-37 pubmed
..We have characterized two partially redundant genes from Saccharomyces cerevisiae, HAL4/SAT4 and HAL5, that encode homologous protein kinases implicated in the regulation of cation uptake...
Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
..The possible relationship between the known functions of these suppressor genes and the progress through the G(1)-S transition is discussed. ..
Mulet J, Alejandro S, Romero C, Serrano R. The trehalose pathway and intracellular glucose phosphates as modulators of potassium transport and general cation homeostasis in yeast. Yeast. 2004;21:569-82 pubmed
..This effect is independent of known regulators of Trk, such as the Hal4 and Hal5 protein kinases and the protein phosphatase calcineurin...
Gey U, Czupalla C, Hoflack B, Krause U, RÃ¶del G. Proteomic analysis reveals a novel function of the kinase Sat4p in Saccharomyces cerevisiae mitochondria. PLoS ONE. 2014;9:e103956 pubmed publisher
..Impairment of the latter enzyme may account for the observed lipoylation defects. ..
Primo C, Ferri Blázquez A, Loewith R, Yenush L. Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation. J Biol Chem. 2017;292:563-574 pubmed publisher
..Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases...
Portillo F, Mulet J, Serrano R. A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport. FEBS Lett. 2005;579:512-6 pubmed
..The effect of Snf1 on Trk is probably indirect and could be mediated by the Sip4 transcriptional activator. ..