Gene Symbol: SAP155
Description: Sap155p
Alias: Sap155p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Miranda M, Masuda C, Ferreira Pereira A, Carvajal E, Ghislain M, Montero Lomeli M. The serine/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res. 2010;10:674-86 pubmed publisher
    ..Sit4p is known to associate with regulatory proteins Sap155p, Sap4p, Sap185p and Sap190p...
  2. Luke M, Della Seta F, Di Como C, Sugimoto H, Kobayashi R, Arndt K. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Mol Cell Biol. 1996;16:2744-55 pubmed
    ..We purified two SIT4-associated proteins, SAP155 and SAP190, and cloned the corresponding genes...
  3. Rohde J, Campbell S, Zurita Martinez S, Cutler N, Ashe M, Cardenas M. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Mol Cell Biol. 2004;24:8332-41 pubmed
    ..b>Sap155, Sap185, or Sap190 can restore these responses...
  4. Manlandro C, Haydon D, Rosenwald A. Ability of Sit4p to promote K+ efflux via Nha1p is modulated by Sap155p and Sap185p. Eukaryot Cell. 2005;4:1041-9 pubmed
    ..In summary, the combined activities of Sap155p and Sap185p appear to control the function of Nha1p in K+ homeostasis via Sit4p.
  5. Jablonowski D, Butler A, Fichtner L, Gardiner D, Schaffrath R, Stark M. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Genetics. 2001;159:1479-89 pubmed
    ..a glutaredoxin and is likely to act at the level of zymocin entry into sensitive cells, while the other encodes Sap155p, one of a family of four related proteins that function positively and interdependently with the Sit4p protein ..
  6. Dechamps C, Portetelle D, Vandenbol M. Multicopy suppression screen in the msb3 msb4 Saccharomyces cerevisiae double mutant, affected in Ypt/RabGAP activity. Biotechnol Lett. 2005;27:1439-49 pubmed
    ..of functional features into four groups: vesicular transport proteins (Sec7p, Vps35p, and Uso1p), a protein involved in cell division (Sap155p), a molecular chaperon (Ssz1p), and a protein associated with the 25S proteasome (Cic1p).
  7. Kuepfer L, Peter M, Sauer U, Stelling J. Ensemble modeling for analysis of cell signaling dynamics. Nat Biotechnol. 2007;25:1001-6 pubmed
    ..Beyond revising our picture of TOR signaling, we expect ensemble modeling to help elucidate other insufficiently characterized cellular circuits. ..
  8. Mehlgarten C, Jablonowski D, Breunig K, Stark M, Schaffrath R. Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4. Mol Microbiol. 2009;73:869-81 pubmed publisher
    ..Collectively, our data suggest that rather than directly targeting Elp1, the Hrr25 kinase indirectly affects Elp1 phosphorylation states through control of Sit4-dependent dephosphorylation of Elp1. ..
  9. Jablonowski D, Täubert J, Bär C, Stark M, Schaffrath R. Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by rapamycin and zymocin. Eukaryot Cell. 2009;8:1637-47 pubmed publisher
    ..specifically induce rapamycin resistance but that this phenotype is reversed in the additional absence of SAP155. Similarly, the rapamycin resistance of an rrd1Delta mutant lacking the Sit4 interactor Rrd1 specifically requires ..

More Information


  1. Garipler G, Mutlu N, Lack N, Dunn C. Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2014;111:1473-8 pubmed publisher
    ..Our work highlights the important role that nutrient-responsive signaling pathways can play in determining the response to mitochondrial dysfunction. ..
  2. Jacinto E, Guo B, Arndt K, Schmelzle T, Hall M. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell. 2001;8:1017-26 pubmed
  3. Munson A, Haydon D, Love S, Fell G, Palanivel V, Rosenwald A. Yeast ARL1 encodes a regulator of K+ influx. J Cell Sci. 2004;117:2309-20 pubmed
    ..High copy suppressors of the hygromycin-B phenotype included SAP155, encoding a protein that interacts with the cell cycle regulator Sit4p, and HAL4 and HAL5, encoding Ser/Thr ..
  4. Kabir M, Kaminska J, Segel G, Bethlendy G, Lin P, Della Seta F, et al. Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiae. Yeast. 2005;22:219-39 pubmed
    ..conditional mutations tor2-21, lst8-2 and rsp5-9 and those caused by the concomitant overexpression of Sit4p and Sap155p. The examination of 73 altered forms of Cct6p revealed that the cct6-24 mutation, containing GDGTT --> AAAAA ..