Gene Symbol: SAM37
Description: SAM complex subunit SAM37
Alias: MAS37, PET3027, TOM37, SAM complex subunit SAM37
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Gratzer S, Lithgow T, Bauer R, Lamping E, Paltauf F, Kohlwein S, et al. Mas37p, a novel receptor subunit for protein import into mitochondria. J Cell Biol. 1995;129:25-34 pubmed
    ..mutants temperature sensitive for growth on a nonfermentable carbon source, we have isolated a gene (termed MAS37) which encodes a novel receptor for protein import into mitochondria...
  2. Waizenegger T, Habib S, Lech M, Mokranjac D, Paschen S, Hell K, et al. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. EMBO Rep. 2004;5:704-9 pubmed
    ..Known constituents of this complex are Tob55 and Mas37. We identified a novel component, Tob38...
  3. Yamano K, Tanaka Yamano S, Endo T. Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40. J Biol Chem. 2010;285:41222-31 pubmed publisher
    ..These results collectively show that Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex. ..
  4. Yamano K, Tanaka Yamano S, Endo T. Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40. EMBO Rep. 2010;11:187-93 pubmed publisher
    ..These results show that Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex. ..
  5. Habib S, Waizenegger T, Lech M, Neupert W, Rapaport D. Assembly of the TOB complex of mitochondria. J Biol Chem. 2005;280:6434-40 pubmed
    ..The other two components of the TOB complex are Tob38, which builds a functional TOB core complex with Tob55, and Mas37, a peripheral member of the complex. We have investigated the biogenesis of the TOB complex...
  6. Stojanovski D, Guiard B, Kozjak Pavlovic V, Pfanner N, Meisinger C. Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol. 2007;179:881-93 pubmed
    ..for efficient membrane integration of the receptor Tom22, whereas assembly of the small Tom proteins depends on Sam37. Thus, the substrate specificity of SAM is not restricted to beta-barrel proteins but also includes the majority ..
  7. Becker T, Guiard B, Thornton N, Zufall N, Stroud D, Wiedemann N, et al. Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex. Mol Biol Cell. 2010;21:3106-13 pubmed publisher
    ..We conclude that the assembly of newly imported Tom40 is directly initiated at the SAM complex by its association with Tom5. The involvement of Mim1 in Tom40 biogenesis can be largely attributed to its role in import of Tom5. ..
  8. Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan M, et al. Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature. 2003;424:565-71 pubmed
    ..b>Mas37 forms a constituent of the SAM complex...
  9. Meisinger C, Pfannschmidt S, Rissler M, Milenkovic D, Becker T, Stojanovski D, et al. The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 2007;26:2229-39 pubmed
    ..It has been assumed that the SAM(core) complex with the subunits Sam35, Sam37 and Sam50 represents the last import stage common to all beta-barrel proteins, followed by splitting in a Tom40-..

More Information


  1. Chan N, Lithgow T. The peripheral membrane subunits of the SAM complex function codependently in mitochondrial outer membrane biogenesis. Mol Biol Cell. 2008;19:126-36 pubmed bacterial outer membranes, but the eukaryotic SAM complex is distinguished by two peripheral subunits, Sam37 and Sam35, that sit on the cytosolic face of the complex...
  2. Dukanovic J, Dimmer K, Bonnefoy N, Krumpe K, Rapaport D. Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Mol Cell Biol. 2009;29:5975-88 pubmed publisher
    ..Three proteins, Sam50 (Tob55), Sam35 (Tob38/Tom38), and Sam37 (Mas37), have been identified as the core constituents of the latter complex...
  3. Thornton N, Stroud D, Milenkovic D, Guiard B, Pfanner N, Becker T. Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins. J Mol Biol. 2010;396:540-9 pubmed publisher
    ..We suggest that the modular composition of the SAM complex provides a flexible platform to integrate the sorting pathways of different precursor proteins and to promote their assembly into oligomeric complexes. ..
  4. Stroud D, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, et al. Biogenesis of mitochondrial ?-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol Biol Cell. 2011;22:2823-33 pubmed publisher
    ..These results indicate the POTRA domain of Sam50 is not essential for recognition of ?-barrel precursors but functions in a subsequent step to promote the release of precursor proteins from the SAM complex. ..
  5. Gebert N, Joshi A, Kutik S, Becker T, McKenzie M, Guan X, et al. Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol. 2009;19:2133-9 pubmed publisher
    ..Our findings reveal a new role for cardiolipin in protein sorting at the mitochondrial outer membrane and bear implications for the pathogenesis of Barth syndrome. ..
  6. Dagley M, Gentle I, Beilharz T, Pettolino F, Djordjevic J, Lo T, et al. Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2. Mol Microbiol. 2011;79:968-89 pubmed publisher
    ..We focus on the mitochondrial outer membrane SAM complex subunit Sam37, demonstrating that it is required for both trafficking of phospholipids between the ER and mitochondria ..
  7. Wenz L, Ellenrieder L, Qiu J, Bohnert M, Zufall N, van der Laan M, et al. Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis. J Cell Biol. 2015;210:1047-54 pubmed publisher protein Sam50, which cooperates with Sam35 in precursor recognition, and the peripheral membrane protein Sam37. The molecular function of Sam37 has been unknown...
  8. Ponce Rojas J, Avendaño Monsalve M, Yañez Falcón A, Jaimes Miranda F, Garay E, Torres Quiroz F, et al. ??'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. FEBS J. 2017;284:814-830 pubmed publisher
    ..cerevisiae is specifically involved in the process of mitochondrial import and functionally cooperates with Sam37, an outer membrane protein subunit of the sorting and assembly machinery complex...
  9. Xue Y, Schmollinger S, Attar N, Campos O, Vogelauer M, Carey M, et al. Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. J Biol Chem. 2017;292:13197-13204 pubmed publisher
    ..Our findings reveal that proper communication between the ER and mitochondria is required for appropriate maintenance of cellular iron levels. ..