Gene Symbol: SAG1
Alias: AG(ALPHA)1, Sag1p
Species: Saccharomyces cerevisiae S288c
Lipke P, Wojciechowicz D, Kurjan J. AG alpha 1 is the structural gene for the Saccharomyces cerevisiae alpha-agglutinin, a cell surface glycoprotein involved in cell-cell interactions during mating. Mol Cell Biol. 1989;9:3155-65 pubmed
We have cloned the alpha-agglutinin structural gene, AG alpha 1, by the isolation of alpha-specific agglutination-defective mutants, followed by isolation of a complementing plasmid...
Huang G, Dougherty S, Erdman S. Conserved WCPL and CX4C domains mediate several mating adhesin interactions in Saccharomyces cerevisiae. Genetics. 2009;182:173-89 pubmed publisher
Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p...
Doi S, Tanabe K, Watanabe M, Yamaguchi M, Yoshimura M. An alpha-specific gene, SAG1 is required for sexual agglutination in Saccharomyces cerevisiae. Curr Genet. 1989;15:393-8 pubmed
..Complementation analysis showed that sag1 and ag alpha 1, the latter being a previously reported alpha-specific mutation, were mutations in the same gene.
Hamada K, Terashima H, Arisawa M, Yabuki N, Kitada K. Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins. J Bacteriol. 1999;181:3886-9 pubmed
..These correlations clearly suggest that GPI-attached proteins have two different signals which act positively or negatively in cell wall incorporation for their cellular localization. ..
Zhao H, Chen M, Shen Z, Kahn P, Lipke P. Environmentally induced reversible conformational switching in the yeast cell adhesion protein alpha-agglutinin. Protein Sci. 2001;10:1113-23 pubmed
..Together, these observations imply that short sequences of high helical propensity are constrained to a beta-rich state by covalent and local charge interactions under native conditions, but form helices under non-native conditions. ..
Frýdlová I, Basler M, Vasicová P, Malcová I, Hasek J. Special type of pheromone-induced invasive growth in Saccharomyces cerevisiae. Curr Genet. 2007;52:87-95 pubmed
..We suggest that partial dependence of the isw2Delta MATalpha invasion on Fus3p and Aga1p corresponds to a weaker pheromone response of this mutant. ..
Zhao H, Shen Z, Kahn P, Lipke P. Interaction of alpha-agglutinin and a-agglutinin, Saccharomyces cerevisiae sexual cell adhesion molecules. J Bacteriol. 2001;183:2874-80 pubmed
..An induced-fit model of binding with substantial apposition of hydrophobic surfaces on the two ligands can explain the observed affinity, kinetics, and specificity and the conformational effects of the binding reaction. ..