RTT109

Summary

Gene Symbol: RTT109
Description: H3 histone acetyltransferase RTT109
Alias: KAT11, KIM2, REM50, H3 histone acetyltransferase RTT109
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Jessulat M, Alamgir M, Salsali H, Greenblatt J, Xu J, Golshani A. Interacting proteins Rtt109 and Vps75 affect the efficiency of non-homologous end-joining in Saccharomyces cerevisiae. Arch Biochem Biophys. 2008;469:157-64 pubmed
    ..Using a plasmid repair assay screen, we identified that the deletion strain for RTT109 had a reduced efficiency for NHEJ in yeast...
  2. Klopf E, Paskova L, Sole C, Mas G, Petryshyn A, Posas F, et al. Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 2009;29:4994-5007 pubmed publisher
    ..A mutant lacking the Asf1-associated H3K56 acetyltransferase Rtt109 or Asf1 itself also showed enhanced stress-induced transcript levels...
  3. Tang Y, Holbert M, Delgoshaie N, Wurtele H, Guillemette B, Meeth K, et al. Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure. 2011;19:221-31 pubmed publisher
    Yeast Rtt109 promotes nucleosome assembly and genome stability by acetylating K9, K27, and K56 of histone H3 through interaction with either of two distinct histone chaperones, Vps75 or Asf1...
  4. Han J, Zhou H, Li Z, Xu R, Zhang Z. The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J Biol Chem. 2007;282:14158-64 pubmed
    ..We and others have shown that the histone acetyltransferase (HAT) Rtt109 is the primary HAT responsible for acetylating H3-Lys-56 in budding yeast...
  5. Radovani E, Cadorin M, Shams T, El Rass S, Karsou A, Kim H, et al. The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation. Eukaryot Cell. 2013;12:654-64 pubmed publisher
    b>Rtt109 is a fungal histone acetyltransferase (HAT) that catalyzes histone H3 acetylation functionally associated with chromatin assembly. Rtt109-mediated H3 acetylation involves two histone chaperones, Asf1 and Vps75...
  6. Guillemette B, Drogaris P, Lin H, Armstrong H, Hiragami Hamada K, Imhof A, et al. H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet. 2011;7:e1001354 pubmed publisher
    ..Genetic studies reveal that the histone acetyltransferases (HATs) Gcn5 and Rtt109 contribute to H3K4 acetylation in vivo...
  7. Wurtele H, Kaiser G, Bacal J, St Hilaire E, Lee E, Tsao S, et al. Histone H3 lysine 56 acetylation and the response to DNA replication fork damage. Mol Cell Biol. 2012;32:154-72 pubmed publisher
  8. Abshiru N, Ippersiel K, Tang Y, Yuan H, Marmorstein R, Verreault A, et al. Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics. J Proteomics. 2013;81:80-90 pubmed publisher
    b>Rtt109 is a fungal-specific histone acetyltransferase (HAT) that associates with either Vps75 or Asf1 to acetylate histone H3...
  9. Kolonko E, Albaugh B, Lindner S, Chen Y, Satyshur K, Arnold K, et al. Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone. Proc Natl Acad Sci U S A. 2010;107:20275-80 pubmed publisher
    ..b>Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with ..

More Information

Publications63

  1. Driscoll R, Hudson A, Jackson S. Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science. 2007;315:649-52 pubmed
    ..These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions are critical for cell survival in the presence of DNA damage during S phase...
  2. Burgess R, Zhou H, Han J, Zhang Z. A role for Gcn5 in replication-coupled nucleosome assembly. Mol Cell. 2010;37:469-80 pubmed publisher
    ..Here we show that Gcn5, a KAT that functions in transcription, works in parallel with Rtt109, the H3 lysine 56 KAT, to promote RC nucleosome assembly...
  3. Erkmann J, Kaufman P. A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance. DNA Repair (Amst). 2009;8:1371-9 pubmed publisher
    In fungal species, lysine 56 of newly synthesized histone H3 molecules is modified by the acetyltransferase Rtt109, which promotes resistance to genotoxic agents...
  4. Lin C, Yuan Y. Structural insights into histone H3 lysine 56 acetylation by Rtt109. Structure. 2008;16:1503-10 pubmed publisher
    ..Saccharomyces cerevisiae Rtt109 is an important class of histone acetyltransferases (HATs), which promote genome stability by directly acetylating ..
  5. Watanabe S, Radman Livaja M, Rando O, Peterson C. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science. 2013;340:195-9 pubmed publisher
    ..Z from nucleosomes. Our study identifies a histone modification that regulates a chromatin remodeling reaction and provides insights into how histone variants and nucleosome turnover can be controlled by chromatin regulators...
  6. Miller A, Yang B, Foster T, Kirchmaier A. Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3. Genetics. 2008;179:793-809 pubmed publisher
    ..We show that mutation of POL30 or loss of K56-acetylation in rtt109 and histone H3 mutants enhances silencing at the crippled HMR locus HMRae via restoring Sir binding and that pol30 ..
  7. Chang M, Bellaoui M, Boone C, Brown G. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A. 2002;99:16934-9 pubmed
    ..These genes may promote replication fork stability or processivity during encounters between replication forks and DNA damage. ..
  8. Keck K, Pemberton L. Interaction with the histone chaperone Vps75 promotes nuclear localization and HAT activity of Rtt109 in vivo. Traffic. 2011;12:826-39 pubmed publisher
    Modification of histones is critical for the regulation of all chromatin-templated processes. Yeast Rtt109 is a histone acetyltransferase (HAT) that acetylates H3 lysines 9, 27 and 56...
  9. Tang Y, Holbert M, Wurtele H, Meeth K, Rocha W, Gharib M, et al. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol. 2008;15:738-45 pubmed publisher
    b>Rtt109, also known as KAT11, is a recently characterized fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome stability...
  10. Endo H, Kawashima S, Sato L, Lai M, Enomoto T, Seki M, et al. Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination. Genes Cells. 2010;15:945-58 pubmed publisher
    ..Here, histone H3 Lys56 acetylation, mediated by the histone acetyltransferase Rtt109 and the histone chaperone Cia1/Asf1, is shown to be required for postreplicative sister chromatid recombination...
  11. Albaugh B, Kolonko E, Denu J. Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex. Biochemistry. 2010;49:6375-85 pubmed publisher
    b>Rtt109 is a histone acetyltransferase (HAT) involved in promoting genomic stability, DNA repair, and transcriptional regulation. Rtt109 associates with the NAP1 family histone chaperone Vps75 and stimulates histone acetylation...
  12. Schneider J, Bajwa P, Johnson F, Bhaumik S, Shilatifard A. Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem. 2006;281:37270-4 pubmed
    ..required for global H3K56 acetylation, which included histone chaperone Asf1 and a protein of an unknown function Rtt109 but not Spt10...
  13. Tsubota T, Berndsen C, Erkmann J, Smith C, Yang L, Freitas M, et al. Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes. Mol Cell. 2007;25:703-12 pubmed
    ..We show here that H3-K56 acetylation is catalyzed when Rtt109, a protein that lacks significant homology to known acetyltransferases, forms an active complex with either of two ..
  14. Yang B, Miller A, Kirchmaier A. HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin. Mol Biol Cell. 2008;19:4993-5005 pubmed publisher
    ..We found silenced loci maintain H3 K56 in a hypoacetylated state, and the absence of this modification in rtt109 mutants was compatible with HM and telomeric silencing...
  15. Park Y, Sudhoff K, Andrews A, Stargell L, Luger K. Histone chaperone specificity in Rtt109 activation. Nat Struct Mol Biol. 2008;15:957-64 pubmed
    b>Rtt109 is a histone acetyltransferase that requires a histone chaperone for the acetylation of histone 3 at lysine 56 (H3K56). Rtt109 forms a complex with the chaperone Vps75 in vivo and is implicated in DNA replication and repair...
  16. Muñoz Galvan S, Jimeno S, Rothstein R, Aguilera A. Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid. PLoS Genet. 2013;9:e1003237 pubmed publisher
    ..acetyl-transferase complex proteins Ahc1 and Ada2, as well as the Hst3 and Hst4 histone deacetylase and the Rtt109 histone acetyl-transferase genes, whose target is histone H3 Lysine 56 (H3K56)...
  17. Tang Y, Meeth K, Jiang E, Luo C, Marmorstein R. Structure of Vps75 and implications for histone chaperone function. Proc Natl Acad Sci U S A. 2008;105:12206-11 pubmed publisher
    ..factor 1, that promotes histone H3-Lys-56 acetylation by the regulation of Ty1 transposition protein 109 (Rtt109) histone acetyltransferase...
  18. Han J, Zhou H, Li Z, Xu R, Zhang Z. Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity. J Biol Chem. 2007;282:28587-96 pubmed
    In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex, with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification...
  19. Han J, Zhou H, Horazdovsky B, Zhang K, Xu R, Zhang Z. Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science. 2007;315:653-5 pubmed
    ..Here we show that regulation of Ty1 transposition gene product 109 (Rtt109) is an H3-K56 HAT...
  20. Berndsen C, Tsubota T, Lindner S, Lee S, Holton J, Kaufman P, et al. Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat Struct Mol Biol. 2008;15:948-56 pubmed
    Histone acetylation and nucleosome remodeling regulate DNA damage repair, replication and transcription. Rtt109, a recently discovered histone acetyltransferase (HAT) from Saccharomyces cerevisiae, functions with the histone chaperone ..
  21. Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, et al. Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. J Biol Chem. 2007;282:37805-14 pubmed
    ..Both S phase checkpoint and SCC defects are phenocopied by H3K56 point mutants. Our findings demonstrate that Hst3-regulated H3K56 acetylation safeguards genome stability by controlling the S phase DNA damage response and promoting SCC. ..
  22. Kadyrova L, Mertz T, Zhang Y, Northam M, Sheng Z, Lobachev K, et al. A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability. PLoS Genet. 2013;9:e1003899 pubmed publisher
    ..Previous studies have determined that in yeast Saccharomyces cerevisiae, Rtt109-dependent acetylation of histone H3 on K56 is an abundant modification that is introduced in chromatin in S phase ..
  23. Su D, Hu Q, Zhou H, Thompson J, Xu R, Zhang Z, et al. Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex. J Biol Chem. 2011;286:15625-9 pubmed publisher
    The histone chaperone Vps75 presents the remarkable property of stimulating the Rtt109-dependent acetylation of several histone H3 lysine residues within (H3-H4)(2) tetramers...
  24. Durairaj G, Chaurasia P, Lahudkar S, Malik S, Shukla A, Bhaumik S. Regulation of chromatin assembly/disassembly by Rtt109p, a histone H3 Lys56-specific acetyltransferase, in vivo. J Biol Chem. 2010;285:30472-9 pubmed publisher
    ..we also find that the deposition of histone H2B on preexisting non-acetylated histone H3 Lys(56) at GAL1 in ?rtt109 is significantly increased independently of histone H3 deposition immediately following transcriptional ..
  25. Alzu A, Bermejo R, Begnis M, Lucca C, Piccini D, Carotenuto W, et al. Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell. 2012;151:835-846 pubmed publisher
  26. Cheng C, Zhao X, Zhang M, Bai F. Absence of Rtt109p, a fungal-specific histone acetyltransferase, results in improved acetic acid tolerance of Saccharomyces cerevisiae. FEMS Yeast Res. 2016;16:fow010 pubmed publisher
    b>RTT109 is a histone acetyltransferase for the acetylation of histone H3. It is still not clear whether RTT109 plays a role in regulation of gene expression under environmental stresses...
  27. Fillingham J, Kainth P, Lambert J, van Bakel H, Tsui K, Pena Castillo L, et al. Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell. 2009;35:340-51 pubmed publisher
    ..expression involves both relief of Rtt106-mediated repression by the activity of the histone acetyltransferase Rtt109 and restriction of Rtt106 to the promoter region by the bromodomain-containing protein Yta7...
  28. Miller A, Chen J, Takasuka T, Jacobi J, Kaufman P, Irudayaraj J, et al. Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes. J Biol Chem. 2010;285:35142-54 pubmed publisher
    ..Together, these results imply that Pol30p affects epigenetic processes by influencing the composition of chromosomal histone modifications. ..
  29. Mimura S, Yamaguchi T, Ishii S, Noro E, Katsura T, Obuse C, et al. Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J Biol Chem. 2010;285:9858-67 pubmed publisher
    ..These results suggest that Cul8-Mms1, as part of various protein complexes, is involved in the regulation of chromatin metabolism. ..
  30. Yang J, Freudenreich C. The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions. DNA Repair (Amst). 2010;9:414-20 pubmed publisher
    ..These include Rtt109, a histone acetyltransferase, responsible for acetylating H3K56, Asf1, a histone H3/H4 chaperone, and Hst3 and ..
  31. Lin C, Wu M, Gay S, Marjavaara L, Lai M, Hsiao W, et al. H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly. PLoS Genet. 2014;10:e1004667 pubmed publisher
  32. Darieva Z, Webber A, Warwood S, Sharrocks A. Protein kinase C coordinates histone H3 phosphorylation and acetylation. elife. 2015;4:e09886 pubmed publisher
    ..cerevisiae under conditions of replicative stress. Pkc1 phosphorylates the histone acetyl transferase Rtt109 and promotes its ability to acetylate H3K56...
  33. Venkatesh S, Smolle M, Li H, Gogol M, Saint M, Kumar S, et al. Set2 methylation of histone H3 lysine?36 suppresses histone exchange on transcribed genes. Nature. 2012;489:452-5 pubmed publisher
    ..By suppressing spurious cryptic transcripts from initiating within ORFs, this pathway is essential to maintain the accuracy of transcription by RNA polymerase?II. ..
  34. Selth L, Lorch Y, Ocampo Hafalla M, Mitter R, Shales M, Krogan N, et al. An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol. 2009;29:4220-34 pubmed publisher
    The histone chaperone Vps75 forms a complex with, and stimulates the activity of, the histone acetyltransferase Rtt109. However, Vps75 can also be isolated on its own and might therefore possess Rtt109-independent functions...
  35. Albaugh B, Arnold K, Lee S, Denu J. Autoacetylation of the histone acetyltransferase Rtt109. J Biol Chem. 2011;286:24694-701 pubmed publisher
    b>Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity...
  36. Wang A, Aristizabal M, Ryan C, Krogan N, Kobor M. Key functional regions in the histone variant H2A.Z C-terminal docking domain. Mol Cell Biol. 2011;31:3871-84 pubmed publisher
    ..Z deposition complex SWR1-C, the histone chaperone Chz1, and histone H2B. These data are consistent with a model in which retaining the variant in chromatin after its deposition by SWR1-C is a crucial determinant of its function. ..
  37. Voichek Y, Bar Ziv R, Barkai N. Expression homeostasis during DNA replication. Science. 2016;351:1087-90 pubmed publisher
    ..This expression homeostasis depends on acetylation of H3 on its internal K56 site by Rtt109/Asf1...
  38. Kuo Y, Henry R, Huang L, Chen X, Stargell L, Andrews A. Utilizing targeted mass spectrometry to demonstrate Asf1-dependent increases in residue specificity for Rtt109-Vps75 mediated histone acetylation. PLoS ONE. 2015;10:e0118516 pubmed publisher
    In Saccharomyces cerevisiae, Rtt109, a lysine acetyltransferase (KAT), associates with a histone chaperone, either Vps75 or Asf1...
  39. Lu P, Kobor M. Maintenance of heterochromatin boundary and nucleosome composition at promoters by the Asf1 histone chaperone and SWR1-C chromatin remodeler in Saccharomyces cerevisiae. Genetics. 2014;197:133-45 pubmed publisher
    ..Z at subtelomeric and euchromatic gene promoters, pointing to a role for Asf1-dependent H3K56 acetylation in SWR1-C biology. ..
  40. Turner E, Malo M, Pisclevich M, Dash M, Davies G, Arnason T, et al. The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression. Eukaryot Cell. 2010;9:1418-31 pubmed publisher
    ..Increased expression of ELP3 and GCN5, as well as genes encoding the HAT Rtt109 and the chromatin assembly factors Msi1 and Asf1, suppressed apc5(CA) defects, while increased APC5 expression ..
  41. Xue Y, Kowalska A, Grabowska K, Przybyt K, Cichewicz M, Del Rosario B, et al. Histone chaperones Nap1 and Vps75 regulate histone acetylation during transcription elongation. Mol Cell Biol. 2013;33:1645-56 pubmed publisher
    ..Loss of the histone acetyltransferase Rtt109 also suppressed ctk1-dependent cryptic transcription...
  42. Lopes da Rosa J, Bajaj V, Spoonamore J, Kaufman P. A small molecule inhibitor of fungal histone acetyltransferase Rtt109. Bioorg Med Chem Lett. 2013;23:2853-9 pubmed publisher
    The histone acetyltransferase Rtt109 is the sole enzyme responsible for acetylation of histone H3 lysine 56 (H3K56) in fungal organisms...
  43. Haber J, Braberg H, Wu Q, Alexander R, Haase J, Ryan C, et al. Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation. Cell Rep. 2013;3:2168-78 pubmed publisher
    ..This approach can reveal functional redundancies that cannot be uncovered through traditional double-mutant analyses. ..
  44. Lin L, Schultz M. Promoter regulation by distinct mechanisms of functional interplay between lysine acetylase Rtt109 and histone chaperone Asf1. Proc Natl Acad Sci U S A. 2011;108:19599-604 pubmed publisher
    ..This modification of H3 is performed by lysine acetylase Rtt109 acting in concert with histone chaperone Asf1...
  45. Stavropoulos P, Nagy V, Blobel G, Hoelz A. Molecular basis for the autoregulation of the protein acetyl transferase Rtt109. Proc Natl Acad Sci U S A. 2008;105:12236-41 pubmed publisher
    b>Rtt109 is a protein acetyltransferase (PAT) that is responsible for the acetylation of lysine-56 of histone 3 (H3K56) in yeast...
  46. Tsabar M, Waterman D, Aguilar F, Katsnelson L, Eapen V, Memisoglu G, et al. Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair. Genes Dev. 2016;30:1211-24 pubmed publisher
    ..Recovery from two repairable DSBs also depends on the histone acetyltransferase Rtt109 and the cullin subunit Rtt101, both of which modify histone H3 that is associated with Asf1...
  47. Simoneau A, Ricard Ã, Weber S, Hammond Martel I, Wong L, Sellam A, et al. Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress. Nucleic Acids Res. 2016;44:2706-26 pubmed publisher
    ..Overall, our data support the concept that chromosome-wide histone deacetylation by sirtuins is critical to mitigate growth defects caused by endogenous genotoxins. ..
  48. Ide S, Saka K, Kobayashi T. Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeast. PLoS Genet. 2013;9:e1003410 pubmed publisher
    ..Here, through a genome-wide screen for genes regulating rDNA copy number, we found that the rtt109 mutant exhibited a hyper-amplification phenotype (?3 times greater than the wild-type level)...
  49. Yang J, Zhang X, Feng J, Leng H, Li S, Xiao J, et al. The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. Cell Rep. 2016;14:1128-1141 pubmed publisher
    ..Therefore, FACT collaborates with CAF-1 and Rtt106 in RC nucleosome assembly. ..
  50. Scholes D, Banerjee M, Bowen B, Curcio M. Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics. 2001;159:1449-65 pubmed
    ..The regulation of Ty1 transposition by components of fundamental pathways required for genome maintenance suggests that Ty1 and yeast have coevolved to link transpositional dormancy to the integrity of the genome. ..
  51. Bar Ziv R, Voichek Y, Barkai N. Chromatin dynamics during DNA replication. Genome Res. 2016;26:1245-56 pubmed publisher
    ..This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5...
  52. Irene C, Theis J, Gresham D, Soteropoulos P, Newlon C. Hst3p, a histone deacetylase, promotes maintenance of Saccharomyces cerevisiae chromosome III lacking efficient replication origins. Mol Genet Genomics. 2016;291:271-83 pubmed publisher
    ..The Ofm phenotype is the first report of a chromosome instability phenotype of an hst3 single mutant. ..
  53. Sundin B, Chiu C, Riffle M, Davis T, Muller E. Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast. 2004;21:793-800 pubmed
    ..We are able to assign new cellular component GO terms to ASF2, TOS4, RTT109, YBR070C, YKR090W, YOL007C, YOL019W and YPR174C. We also have localization data for 21 other proteins...
  54. Hiraga S, Botsios S, Donaldson A. Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning. J Cell Biol. 2008;183:641-51 pubmed publisher
    ..Asf1 stimulates acetylation of histone H3 lysine 56 (H3K56) by the histone acetyltransferase Rtt109. Analysis of rtt109Delta and H3K56 mutants suggests that the acetylation/deacetylation cycle of the H3K56 residue ..