Gene Symbol: RTR1
Description: RNA polymerase II subunit B1 CTD phosphatase RTR1
Alias: RNA polymerase II subunit B1 CTD phosphatase RTR1
Species: Saccharomyces cerevisiae S288c
Duan R, Rhie B, Ryu H, Ahn S. The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Biochem Biophys Res Commun. 2013;: pubmed publisher
Soares L, Buratowski S. Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor. J Biol Chem. 2012;287:15219-31 pubmed publisher
..Although Swd2 is normally required for bringing APT to genes, deletion of SET1 restores both viability and APT recruitment to a strain lacking Swd2. We propose a model in which Swd2 is required for APT to overcome antagonism by COMPASS. ..
Mosley A, Pattenden S, Carey M, Venkatesh S, Gilmore J, Florens L, et al
. Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mol Cell. 2009;34:168-78 pubmed publisher
..We show that a conserved protein of unknown function, Rtr1, localizes within coding regions, with maximum levels of enrichment occurring between the peaks of S5-P and S2-P ..
Hsu P, Yang F, Smith Kinnaman W, Yang W, Song J, Mosley A, et al
. Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD. J Mol Biol. 2014;426:2970-81 pubmed publisher
..b>Rtr1 was recently proposed to be the enzyme responsible for the transition of PolII into the elongation and termination ..
Hodko D, Ward T, Chanfreau G. The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases. RNA. 2016;22:559-70 pubmed publisher
..We show that the 3'UTR of the RTR1 mRNA contains a cis element that destabilizes this mRNA...
Gibney P, Fries T, Bailer S, Morano K. Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot Cell. 2008;7:938-48 pubmed publisher
..Multiple lines of evidence support a role for this gene family in transcription, prompting us to rename YER139C RTR1 (regulator of transcription)...
Smith Kinnaman W, Berna M, Hunter G, True J, Hsu P, Cabello G, et al
. The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae. Mol Biosyst. 2014;10:1730-41 pubmed publisher
The phosphatase Rtr1 has been implicated in dephosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) during transcription elongation and in regulation of nuclear import of RNAPII...
Duan R, Rhie B, Ryu H, Ahn S. The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Biochem Biophys Res Commun. 2013;441:266-70 pubmed
Braunwarth A, Fromont Racine M, Legrain P, Bischoff F, Gerstberger T, Hurt E, et al
. Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae. J Biol Chem. 2003;278:15397-405 pubmed
..Based on these results and the exclusive conservation of the protein in the fungal kingdom, we hypothesize that Yrb30p represents a novel modulator of the Ran GTPase switch related to fungal lifestyle. ..