Gene Symbol: RSC58
Species: Saccharomyces cerevisiae S288c
Carey M, Li B, Workman J. RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell. 2006;24:481-7 pubmed
..Thus, RSC can recognize acetylated nucleosomes and facilitate passage of Pol II through them. These data support the view that histone modifications regulate accessibility of the coding region to Pol II. ..
Campsteijn C, Wijnands Collin A, Logie C. Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet. 2007;3:e92 pubmed
..Taken together, our results implicate RSC in regulation of the G1/S-phase transition and establish a hitherto unanticipated role for RSC-mediated chromatin remodeling in ploidy maintenance. ..
Zhou W, Ryan J, Zhou H. Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem. 2004;279:32262-8 pubmed
..Taken together, these results show that protein sumoylation is broadly involved in many cellular functions and this mass spectrometry-based proteomic approach is useful in studying the regulation of protein sumoylation in the cells. ..
Lia G, Praly E, Ferreira H, Stockdale C, Tse Dinh Y, Dunlap D, et al
. Direct observation of DNA distortion by the RSC complex. Mol Cell. 2006;21:417-25 pubmed
..These observations support the idea that the ATPase motors of the Snf2 family of proteins act as DNA translocases specialized to generate transient distortions in DNA structure. ..
Kurat C, Lambert J, van Dyk D, Tsui K, van Bakel H, Kaluarachchi S, et al
. Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein. Genes Dev. 2011;25:2489-501 pubmed publisher
..Our study identified the chromatin boundary protein Yta7 as a key regulator that links S-phase kinases with RNAPII function at cell cycle-regulated histone gene promoters. ..
Lorch Y, Maier Davis B, Kornberg R. Chromatin remodeling by nucleosome disassembly in vitro. Proc Natl Acad Sci U S A. 2006;103:3090-3 pubmed
..RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo. ..
Fischer C, Saha A, Cairns B. Kinetic model for the ATP-dependent translocation of Saccharomyces cerevisiae RSC along double-stranded DNA. Biochemistry. 2007;46:12416-26 pubmed
..These results are further discussed in the context of previously published studies of RSC and other DNA translocases. ..
Andress E, Holic R, Edelmann M, Kessler B, Yu V. Dia2 controls transcription by mediating assembly of the RSC complex. PLoS ONE. 2011;6:e21172 pubmed publisher
..Dia2, by controlling the RSC chromatin remodeller, fine-tunes transcription by controlling nucleosome positioning during transcriptional activation and repression. ..
Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..