Gene Symbol: RRN10
Description: Rrn10p
Alias: Rrn10p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Siddiqi I, Dodd J, Vu L, Eliason K, Oakes M, Keener J, et al. Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF. EMBO J. 2001;20:4512-21 pubmed
    UAF, a yeast RNA polymerase I transcription factor, contains Rrn5p, Rrn9p, Rrn10p, histones H3 and H4, and uncharacterized protein p30...
  2. Steffan J, Keys D, Vu L, Nomura M. Interaction of TATA-binding protein with upstream activation factor is required for activated transcription of ribosomal DNA by RNA polymerase I in Saccharomyces cerevisiae in vivo. Mol Cell Biol. 1998;18:3752-61 pubmed
    ..three mutations in RRN9 that abolish the interaction of Rrn9p with TBP without affecting its interaction with Rrn10p, another subunit of UAF...
  3. Ha C, Sung M, Huh W. Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res. 2012;40:4892-903 pubmed publisher
    ..Furthermore, Nsi1 contributes to the longevity of yeast cells. Taken together, our findings suggest that Nsi1 is a new rDNA silencing factor that contributes to rDNA stability and lifespan extension in S. cerevisiae. ..
  4. Keys D, Lee B, Dodd J, Nguyen T, Vu L, Fantino E, et al. Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. Genes Dev. 1996;10:887-903 pubmed
    ..transcription factor, UAF (upstream activation factor) which contains three proteins encoded by RRN5, RRN9, and RRN10 genes, respectively, and probably two additional uncharacterized proteins...
  5. Chuwattanakul V, Sugiyama M, Khatun F, Kurata K, Tomita I, Kaneko Y, et al. Increased transcription of NOP15, involved in ribosome biogenesis in Saccharomyces cerevisiae, enhances the production yield of RNA as a source of nucleotide seasoning. J Biosci Bioeng. 2012;114:17-22 pubmed publisher
    ..than the wild-type strain through the isolation of dominant suppressors (designated SupA to SupG strains) from a ?rrn10 disruptant showing decreased rRNA transcription...
  6. Keener J, Dodd J, Lalo D, Nomura M. Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Proc Natl Acad Sci U S A. 1997;94:13458-62 pubmed
    ..identified in purified UAF, three are encoded by genes required for Pol I transcription in vivo: RRN5, RRN9, and RRN10. Two others, p30 and p18, have remained uncharacterized...
  7. Keener J, Josaitis C, Dodd J, Nomura M. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem. 1998;273:33795-802 pubmed
    ..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription. ..
  8. Aprikian P, Moorefield B, Reeder R. TATA binding protein can stimulate core-directed transcription by yeast RNA polymerase I. Mol Cell Biol. 2000;20:5269-75 pubmed
    ..This dual function of TBP, serving as a critical member of a core promoter complex as well as a contact point for upstream activators, appears similar to the dual roles that TBP also plays in transcription by RNA polII. ..
  9. Merz K, Hondele M, Goetze H, Gmelch K, Stoeckl U, Griesenbeck J. Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev. 2008;22:1190-204 pubmed publisher
    ..We demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. ..

More Information


  1. Khatun F, Kurata K, Chuwattanakul V, Sugiyama M, Kaneko Y, Harashima S. Increased transcription of RPL40A and RPL40B is important for the improvement of RNA production in Saccharomyces cerevisiae. J Biosci Bioeng. 2013;116:423-32 pubmed publisher
    ..Efficient transcription of rDNA is very important to construct yeast strains with high RNA content. The gene RRN10, which encodes, a component of the upstream activation factor, is essential to promote high-level transcription of ..