Gene Symbol: RPS23A
Description: ribosomal 40S subunit protein S23A
Alias: ribosomal 40S subunit protein S23A
Species: Saccharomyces cerevisiae S288c
Anthony R, Liebman S. Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Genetics. 1995;140:1247-58 pubmed
..coli results. Although mutations in these different parts of RPS28 have opposite affects on translational accuracy or antibiotic sensitivity, additive phenotypes can be observed when opposing mutations are combined in the same protein. ..
Alksne L, Anthony R, Liebman S, Warner J. An accuracy center in the ribosome conserved over 2 billion years. Proc Natl Acad Sci U S A. 1993;90:9538-41 pubmed
..coli model. Thus, the interplay of these three proteins to provide the optimal level of accuracy of translation has been conserved during the 2 billion years of evolution that separate E. coli from S. cerevisiae. ..
Synetos D, Frantziou C, Alksne L. Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Biochim Biophys Acta. 1996;1309:156-66 pubmed
..These results establish the role of Lys-62 of S28 in optimizing translational accuracy and provide a more precise view of the functional role of two important ribosomal proteins. ..
Ranish J, Hahn S, Lu Y, Yi E, Li X, Eng J, et al
. Identification of TFB5, a new component of general transcription and DNA repair factor IIH. Nat Genet. 2004;36:707-13 pubmed
..The identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease. ..
Chiu W, Wagner S, HerrmannovÃ¡ A, Burela L, Zhang F, Saini A, et al
. The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons. Mol Cell Biol. 2010;30:4415-34 pubmed publisher
Otaka E, Higo K, Osawa S. Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast. Biochemistry. 1982;21:4545-50 pubmed
..T., Möller, W., Amons, R., & Yaguchi, M. (1980) in Ribosomes: Structure, Function and Genetics (Chambliss, G., et al., Eds.) pp 297-332, University Park Press, Baltimore, MD; M. Yaguchi, unpublished experiments]. ..
ElAntak L, Wagner S, HerrmannovÃ¡ A, KarÃ¡skovÃ¡ M, Rutkai E, Lukavsky P, et al
. The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection. J Mol Biol. 2010;396:1097-116 pubmed publisher
..Taken together, we propose that eIF3j/HCR1 closely cooperates with the eIF3b/PRT1 RRM and eIF1A on the ribosome to ensure proper formation of the scanning-arrested conformation required for stringent AUG recognition. ..
Becker T, Armache J, Jarasch A, Anger A, Villa E, Sieber H, et al
. Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol. 2011;18:715-20 pubmed publisher
..Collectively, our data provide structural insights into how stalled mRNA is recognized on the ribosome and how the eRF complex can simultaneously recognize stop codons and catalyze peptide release. ..